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List of works by Luke D. Lavis

3D ATAC-PALM: super-resolution imaging of the accessible genome

scientific article published on 16 March 2020

3D imaging of Sox2 enhancer clusters in embryonic stem cells

scientific article

A Sensitive and Robust Enzyme Kinetic Experiment Using Microplates and Fluorogenic Ester Substrates

A dynamic interplay of enhancer elements regulates Klf4 expression in naïve pluripotency

scientific article published in September 2017

A general method to fine-tune fluorophores for live-cell and in vivo imaging

scientific article published on 4 September 2017

A general method to improve fluorophores for live-cell and single-molecule microscopy

scientific article

A general method to optimize and functionalize red-shifted rhodamine dyes

scientific article published on 27 July 2020

A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells

scientific article published on 10 June 2008

A platform for brain-wide imaging and reconstruction of individual neurons

scientific article published on 20 January 2016

A toolbox for multiplexed super-resolution imaging of the E. coli nucleoid and membrane using novel PAINT labels

scientific article published in Scientific Reports

Accurate measurement of fast endocytic recycling kinetics in real time

scientific article published on 22 January 2020

Advances in the chemistry of small molecule fluorescent probes

scientific article

Bioorthogonal labeling with tetrazine-dyes for super-resolution microscopy

scientific article published on 19 July 2019

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

scientific article published on 01 August 2019

Bright building blocks for chemical biology

scientific article

Bright ideas for chemical biology

scientific article

Bright photoactivatable fluorophores for single-molecule imaging

scientific article

Bright photoactivatable fluorophores for single-molecule imaging

Caged naloxone reveals opioid signaling deactivation kinetics

scientific article published on 19 August 2013

Carbofluoresceins and carborhodamines as scaffolds for high-contrast fluorogenic probes

scientific article published on 24 April 2013

Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl Pair

scholarly article by Todd D Gruber et al published 16 August 2018 in ACS Chemical Biology

Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl Pair

Cellular uptake of ribonuclease A relies on anionic glycans

scientific article

Chemistry Is Dead. Long Live Chemistry!

scientific article

Chemistry of Photosensitive Fluorophores for Single-Molecule Localization Microscopy.

scientific article published on 13 May 2019

Cohesin Can Remain Associated With Chromosomes During DNA Replication

Cohesin Can Remain Associated with Chromosomes during DNA Replication

scientific article published on September 2017

Correction to Rational Design of Fluorogenic and Spontaneously Blinking Labels for Super-Resolution Imaging

scientific article published on 16 September 2020

Cytotoxic ribonucleases: the dichotomy of Coulombic forces

scientific article published on 18 August 2007

Deconstructing behavioral neuropharmacology with cellular specificity

scientific article

Decoupled roles for the atypical, bifurcated binding pocket of the ybfF hydrolase

scientific article

Desensitized D2 autoreceptors are resistant to trafficking

scientific article

Design and Synthesis of a Calcium-Sensitive Photocage

scientific article published on 24 May 2016

Design and Synthesis of a Calcium-Sensitive Photocage

Development of photostable fluorophores for molecular imaging

scientific article

Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning

scientific article published on 12 December 2020

Distinct substrate selectivity of a metabolic hydrolase from Mycobacterium tuberculosis

scientific article

Enabling <i>In Vivo</i> Photocatalytic Activation of Rapid Bioorthogonal Chemistry by Repurposing Silicon-Rhodamine Fluorophores as Cytocompatible Far-Red Photocatalysts

scientific article published in 2021

Ester bonds in prodrugs

scientific article

Evaluation of the Ser-His Dipeptide, a Putative Catalyst of Amide and Ester Hydrolysis

scientific article published on 11 July 2016

Evolved differences in larval social behavior mediated by novel pheromones

scientific article

Excitation spectra and brightness optimization of two-photon excited probes

scientific article published on 21 February 2012

Facile and General Synthesis of Photoactivatable Xanthene Dyes

Facile and general synthesis of photoactivatable xanthene dyes

scientific article published on 26 September 2011

Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells

scientific article

Fluorogenic label for biomolecular imaging

scientific article

Fluorogenic structure activity library pinpoints molecular variations in substrate specificity of structurally homologous esterases

scientific article published in Journal of Biological Chemistry

General Synthetic Method for Si-Fluoresceins and Si-Rhodamines

scientific article published on 9 August 2017

Glutamate-induced RNA localization and translation in neurons

scientific article published on 17 October 2016

High-density three-dimensional localization microscopy across large volumes

scientific article

Histochemistry: live and in color

scientific article published on February 2011

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

scientific article published in Science

Imaging live-cell dynamics and structure at the single-molecule level

scientific article published on May 2015

Improved HaloTag Ligand Enables BRET Imaging With NanoLuc

scientific article published on 01 January 2019

Innenrücktitelbild: Synthesis of a Far-Red Photoactivatable Silicon-Containing Rhodamine for Super-Resolution Microscopy (Angew. Chem. 5/2016)

Inside Back Cover: Synthesis of a Far-Red Photoactivatable Silicon-Containing Rhodamine for Super-Resolution Microscopy (Angew. Chem. Int. Ed. 5/2016)

Integrated action of pheromone signals in promoting courtship behavior in male mice

scientific article

Intraspecies regulation of ribonucleolytic activity

scientific article published on 23 October 2007

Isomeric Tuning Yields Bright and Targetable Red Ca2+ Indicators

scientific article published on 23 August 2019

Ketamine inside neurons?

scientific article published on 17 July 2015

Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

scientific article

Latent blue and red fluorophores based on the trimethyl lock

scientific article

Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

scientific article published on 27 April 2020

Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin

scientific article published on 10 October 2016

Making biology transparent

scientific article

Measuring the Global Substrate Specificity of Mycobacterial Serine Hydrolases Using a Library of Fluorogenic Ester Substrates

article published in 2018

Multi-Color Single-Molecule Imaging Uncovers Extensive Heterogeneity in mRNA Decoding

scientific article published on 06 June 2019

Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging

scientific article published on 06 January 2020

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission

scientific article published in May 2018

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter

scientific article published on 14 September 2020

Nuclear Microenvironments Modulate Transcription From Low-Affinity Enhancers

Nuclear microenvironments modulate transcription from low-affinity enhancers.

scientific article published on 2 November 2017

Onconase cytotoxicity relies on the distribution of its positive charge

scientific article

Optimization of fluorophores for chemical tagging and immunohistochemistry of Drosophila neurons

scientific article published in PLoS ONE

Photoactivatable drugs for nicotinic optopharmacology

Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine

article published in 2019

Quantifying transcription factor binding dynamics at the single-molecule level in live cells

scientific article

RNA Polymerase II cluster dynamics predict mRNA output in living cells

scientific article published on 03 May 2016

Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis

scientific article

Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems

scientific article published on 15 July 2020

Rational Design of Fluorogenic and Spontaneously Blinking Labels for Super-Resolution Imaging

scientific article published on 05 September 2019

Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

scientific article published on 3 August 2016

Real-time quantification of single RNA translation dynamics in living cells

scientific article published on 5 May 2016

Rhodium(III)-catalyzed indazole synthesis by C-H bond functionalization and cyclative capture

scientific article published on 3 May 2013

Robust model-based analysis of single-particle tracking experiments with Spot-On.

scientific article published on 4 January 2018

Selective esterase-ester pair for targeting small molecules with cellular specificity

scientific article

Semisynthetic fluorescent pH sensors for imaging exocytosis and endocytosis.

scientific article published on 10 November 2017

Single-molecule tracking of the transcription cycle by sub-second RNA detection

scientific article published on 28 January 2014

Spot-On: robust model-based analysis of single-particle tracking experiments

Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

scientific article

Stochastic Protein Labeling Enables Long-Term Single Molecule Observation in vivo

Synthesis and utility of fluorogenic acetoxymethyl ethers

scientific article published on January 2011

Synthesis of Janelia Fluor HaloTag and SNAP-Tag Ligands and Their Use in Cellular Imaging Experiments

scientific article published in January 2017

Synthesis of a Far-Red Photoactivatable Silicon-Containing Rhodamine for Super-Resolution Microscopy

scientific article published on 11 December 2015

Synthesis of a Far-Red Photoactivatable Silicon-Containing Rhodamine for Super-Resolution Microscopy

Synthesis of rhodamines from fluoresceins using Pd-catalyzed C-N cross-coupling

scientific article

Synthetic and genetically encoded fluorescent neural activity indicators

scientific article published on 14 February 2018

Teaching Old Dyes New Tricks: Biological Probes Built from Fluoresceins and Rhodamines

scientific article published on 7 April 2017

The chemistry of small-molecule fluorogenic probes

scientific article published on January 2013

The structural basis for the narrow substrate specificity of an acetyl esterase from Thermotoga maritima

scientific article

Trimethyl lock: a stable chromogenic substrate for esterases

scientific article

Tuning the pK(a) of fluorescein to optimize binding assays

scientific article published on 3 August 2007

Unraveling cell-to-cell signaling networks with chemical biology

scientific article published in May 2017

Virginia Orange: A Versatile, Red-Shifted Fluorescein Scaffold for Single- and Dual-Input Fluorogenic Probes

scientific article

Visualizing long-term single-molecule dynamics in vivo by stochastic protein labeling

scientific article published on 28 December 2017

What if we just give everything away?

scientific article

Whole-Cell, 3D, and Multicolor STED Imaging with Exchangeable Fluorophores

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