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List of works by Renu Wadhwa

2,3-Dihydro-3β-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity

scientific article published on 18 October 2017

A Novel Alternatively Spliced Form of Murine Vascular Endothelial Growth Factor, VEGF 115 ⬇️

scientific article published on January 30, 1998

A novel putative collaborator of p19ARF

scientific article

A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation

scientific article

Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.

scientific article published on 21 September 2005

Addressing Challenges to Enhance the Bioactives of Withania somnifera through Organ, Tissue, and Cell Culture Based Approaches.

scientific article published on 16 February 2017

Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control

scientific article

An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?

scientific article

An antibody-conjugated internalizing quantum dot suitable for long-term live imaging of cells

scientific article published on February 2007

Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin.

scientific article published in January 2018

Anticancer activity of the supercritical extract of Brazilian green propolis and its active component, artepillin C: Bioinformatics and experimental analyses of its mechanisms of action.

scientific article published on 22 January 2018

Ashwagandha Leaf Derived Withanone Protects Normal Human Cells Against the Toxicity of Methoxyacetic Acid, a Major Industrial Metabolite ⬇️

scientific article published on May 4, 2011

Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity

scientific article

Bioinformatics and Molecular Insights to Anti-Metastasis Activity of Triethylene Glycol Derivatives

scientific article published on 30 July 2020

Biotechnological interventions in Withania somnifera (L.) Dunal

scientific article published on 19 March 2015

CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis

scientific article published on 4 August 2015

CARF Is a vital dual regulator of cellular senescence and apoptosis

scientific article published on 10 November 2008

CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway.

scientific article published on April 2007

CARF enrichment promotes epithelial-mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target.

scientific article published on 11 May 2018

CARF is a multi-module regulator of cell proliferation and a molecular bridge between cellular senescence and carcinogenesis.

scientific article published on 25 July 2017

CARF: an emerging regulator of p53 tumor suppressor and senescence pathway.

scientific article published on 08 May 2008

Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences.

scientific article published on 4 June 2018

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.

scientific article

Cell migration and metastasis as targets of small RNA-based molecular genetic analyses.

scientific article

Circulating mortalin autoantibody--a new serological marker of liver cirrhosis

scientific article published on 24 April 2015

Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53

scientific journal article

Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling

scientific article

Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation

scientific article published in 2015

Correlation between complementation group for immortality and the cellular distribution of mortalin.

scientific article published on January 1995

Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review).

scientific article

Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves.

scientific article published on 8 July 2009

Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1.

scientific article published on September 1997

Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences

scientific article

Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts.

scientific article published on August 1993

Editorial: special issue of Biogerontology on brain aging.

scientific article published on 5 October 2008

Effect of Ashwagandha Withanolides on Muscle Cell Differentiation

scientific article published on 4 October 2021

Effect of sodium hypophosphite feeding on adenosine triphosphatase activity in ageing Zaprionus paravittiger (Diptera).

scientific article published in January 1989

Effect of sodium selenite on antioxidative enzymes of banana fruitfly

scientific article published in January 1989

Elevated levels of mortalin expression in human brain tumors.

scientific article published in November 1997

Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence

scientific article

Enhanced expression of multiple forms of VEGF is associated with spontaneous immortalization of murine fibroblasts.

scientific article published on December 1994

Evaluation and selection of candidate reference genes for normalization of quantitative RT-PCR in Withania somnifera (L.) Dunal

scientific article

Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha.

scientific article published in December 2004

Expression analysis of mortalin, a unique member of the Hsp70 family of proteins, in rat tissues.

scientific article published on April 1997

Expression of noncoding vault RNA in human malignant cells and its importance in mitoxantrone resistance

scientific article

Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.

scientific article

Fate of bone marrow mesenchymal stem cells following the allogeneic transplantation of cartilaginous aggregates into osteochondral defects of rabbits.

scientific article published on 26 August 2010

Fate of bone marrow mesenchymal stromal cells following autologous transplantation in a rabbit model of osteonecrosis.

scientific article published in February 2016

Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots

scientific article

Functional significance of minor structural and expression changes in stress chaperone mortalin.

scientific article

Functional significance of point mutations in stress chaperone mortalin and their relevance to Parkinson disease.

scientific article

Genetic differences between the pancytosolic and perinuclear forms of murine mortalin.

scientific article published on August 1996

Geroprotection by glycerol: insights to its mechanisms and clinical potentials.

scientific article published on May 2006

Gros1, a potential growth suppressor on chromosome 1: its identity to basement membrane-associated proteoglycan, leprecan

scientific article

Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis.

scientific article published on 5 April 2013

Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94.

scientific article published in July 2001

Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.

scientific article

Identification and functional characterization of nuclear mortalin in human carcinogenesis.

scientific article

Identification of genetic events involved in early steps of immortalization of mouse fibroblasts.

scientific article published on December 1994

Imminent approaches towards molecular interventions in ageing.

scientific article

Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.

scientific article published on November 1998

Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.

scientific article published on 4 March 2011

Induction of senescence in cancer cells by 5'-Aza-2'-deoxycytidine: Bioinformatics and experimental insights to its targets

scientific article published on 02 August 2017

Internalizing antibody-based targeted gene delivery for human cancer cells.

scientific article

Involvement of hippocampal Arc in amnesia and its recovery by alcoholic extract of Ashwagandha leaves

scientific article published on 3 September 2013

Life span studies in Zaprionus paravittiger with sodium hypophosphite feeding

scientific article published in January 1986

Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts

scientific article published on 17 December 2003

Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis

scholarly article

Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF.

scientific article published on 26 July 2016

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties

scientific article published in 2021

Malignant transformation of NIH3T3 cells by overexpression of mot-2 protein.

scientific article published on August 1998

Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology

scientific article published on 18 March 2008

MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region

scientific article

Mimotope-hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations.

scientific article published in January 2005

Mixtures of Three Mortaparibs with Enhanced Anticancer, Anti-Migration, and Antistress Activities: Molecular Characterization in p53-Null Cancer Cells

scientific article published on 17 June 2024

Molecular Characterization and Enhancement of Anticancer Activity of Caffeic Acid Phenethyl Ester by γ Cyclodextrin

scientific article published on 11 August 2016

Molecular Insights Into Withaferin-A-Induced Senescence: Bioinformatics and Experimental Evidence to the Role of NFκB and CARF

scientific article published on 01 January 2019

Molecular characterization of apoptosis induced by CARF silencing in human cancer cells

scientific article published on 5 November 2010

Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.

scientific article

Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein

scientific article published on 28 January 2014

Molecular dynamics-based identification of novel natural mortalin-p53 abrogators as anticancer agents

scientific article

Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization

scientific article published on 16 October 2013

Mortalin antibody-conjugated quantum dot transfer from human mesenchymal stromal cells to breast cancer cells requires cell-cell interaction

scientific article

Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids

scientific article published on 11 October 2017

Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates

scientific article published on December 2003

Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation

scientific article

Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

scientific article

Mortalin: present and prospective

scientific article

Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts.

scientific article published on 08 September 2015

Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells

scientific article published on 21 August 2020

Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts

scientific article

On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.

scientific article

On the cytosolic and perinuclear mortalin: an insight by heat shock.

scientific article published on May 1993

Organic cultivation of Ashwagandha with improved biomass and high content of active Withanolides: Use of Vermicompost

scientific article published on 16 April 2018

Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts

scientific article published on 01 May 2003

Phosphatidylserine Exposed Lipid Bilayer Models for Understanding Cancer Cell Selectivity of Natural Compounds: A Molecular Dynamics Simulation Study

scientific article published in January 2022

Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts

scientific article published on 01 May 2006

Protection from aging by small chaperones: A trade-off with cancer?

scientific article published on June 2010

Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells ⬇️

scientific article published on November 11, 2011

Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.

scientific article published on 24 March 2006

Quantum dot-based mortalin staining as a visual assay for detection of induced senescence in cancer cells

scientific article published on April 2007

Quantum dot-based protein imaging and functional significance of two mitochondrial chaperones in cellular senescence and carcinogenesis

scientific article published on May 2006

Quantum dots in bio-imaging: Revolution by the small

scientific article

Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells.

scientific article published on April 2004

Relevance of mortalin to cancer cell stemness and cancer therapy.

scientific article published on 06 February 2017

Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling

scientific article

Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect

scientific article

Senescence and immortalization of human cells.

scientific article

Serum-free isolation and culture system to enhance the proliferation and bone regeneration of adipose tissue-derived mesenchymal stem cells

scientific article published on 15 January 2015

Stable and nondisruptive in vitro/in vivo labeling of mesenchymal stem cells by internalizing quantum dots

scientific article published in March 2009

Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.

scientific article published on 9 March 2016

Stress chaperone mortalin regulates human melanogenesis.

scientific article

Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway.

scientific article published on March 2007

Structurally and functionally distinct mouse hsp70 family members Mot-1 and Mot-2 proteins are encoded by two alleles

scientific article published on 01 June 2000

TAS6417, a novel epidermal growth factor receptor inhibitor targeting exon 20 insertion mutations.

scientific article

Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells

scientific article

Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes

scientific article

Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells.

scientific article

The versatile stress protein mortalin as a chaperone therapeutic agent.

scientific article published on January 2009

Transcriptional inactivation of p53 by deletions and single amino acid changes in mouse mot-1 protein

scientific article published on 01 December 2000

Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

scientific article

Tumor suppressor activity of miR-451: Identification of CARF as a new target

scientific article published on 10 January 2018

Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.

scientific article published on June 2006

Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation.

scientific article published on 24 September 2004

Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion

scientific article published on 01 February 1999

Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity

scientific article

Water extract of Ashwagandha leaves has anticancer activity: identification of an active component and its mechanism of action

scientific article (publication date: 2013)

Water extract of ashwagandha leaves limits proliferation and migration, and induces differentiation in glioma cells

scientific article

Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences

scientific article

Withania somnifera water extract as a potential candidate for differentiation based therapy of human neuroblastomas

scientific article

Withanone binds to mortalin and abrogates mortalin–p53 complex: Computational and experimental evidence

article

Withanone-rich combination of Ashwagandha withanolides restricts metastasis and angiogenesis through hnRNP-K.

scientific article published on 18 September 2014

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