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List of works by Colm J. Ryan

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.

scientific article

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.

scientific article published on 13 December 2016

Accurate prediction of kinase-substrate networks using knowledge graphs

scientific article published on 03 December 2020

All or nothing: protein complexes flip essentiality between distantly related eukaryotes.

scientific article

Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

scientific article published in Scientific Reports

CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer

scientific article published on 11 July 2017

CancerGD: a resource for identifying and interpreting genetic dependencies in cancer

scholarly article published 26 October 2016

Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival

article

Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.

scientific article

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

scientific article published on 13 July 2018

Comparative interaction networks: bridging genotype to phenotype.

scientific article published on January 2012

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

scientific article published on 16 February 2021

DAISY: picking synthetic lethals from cancer genomes

scientific article published in September 2014

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

scientific article published in April 2018

Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells

scientific article

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

scientific article published on 24 January 2020

Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast

scientific article

Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast

scientific article

Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression.

scientific article

Hierarchical modularity and the evolution of genetic interactomes across species.

scientific article

High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe.

scientific article

Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function

scientific article published on 22 February 2014

Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer

scientific article published on 18 June 2018

Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels

scientific article published in January 2018

Improved functional overview of protein complexes using inferred epistatic relationships.

scientific article

Imputing and predicting quantitative genetic interactions in epistatic MAPs.

scientific article published on January 2011

Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

scientific article published on 28 May 2020

Key functional regions in the histone variant H2A.Z C-terminal docking domain

scientific article published on 26 July 2011

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

scientific article published on 2 March 2016

Missing value imputation for epistatic MAPs

scientific article

Paralog buffering contributes to the variable essentiality of genes in cancer cell lines

scientific article published on 25 October 2019

Synthetic Lethality and Cancer - Penetrance as the Major Barrier

article by Colm J. Ryan et al published October 2018 in Trends in cancer

Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation.

scientific article published on 06 June 2013

Systems biology: old news or new stimulus for biochemistry

scientific article published on 26 October 2018

The histone variant H2A.Z promotes splicing of weak introns.

scientific article published on April 2017

The yeast SR-like protein Npl3 links chromatin modification to mRNA processing

scientific article

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