List of works - Nicholas J Watkins

A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP

scientific article

A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation

scientific article

Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex

scientific article

Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

scientific journal article

Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing

scientific article

Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.

scientific article

Comparison of the yeast and human nuclear exosome complexes

scientific article

Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP

scientific article

Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.

scientific article published on 20 July 2009

Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.

scientific article published on 28 September 2007

In vitro assembly of the mouse U14 snoRNP core complex and identification of a 65-kDa box C/D-binding protein.

scientific article

Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery

scientific article

Interactions and activities of factors involved in the late stages of human 18S rRNA maturation

scientific article published on 13 January 2019

Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis

scientific article

Minor spliceosome components are predominantly localized in the nucleus

scientific article

Nucleolar disruption leads to the spatial separation of key 18S rRNA processing factors.

scientific article published in February 2012

Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies

scientific article

Processing of vertebrate box C/D small nucleolar RNAs in plant cells ⬇️

scientific article published on April 1, 1998

Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits

scientific article

Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D snoRNPs

scientific article published on July 2006

Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP

scientific article

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

scientific journal article

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans

scientific article published on 14 July 2016

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans

scientific article published on 31 March 2016

The U7 small nuclear RNA genes of Xenopus borealis

scientific article (publication date: August 1992)

The Xenopus U7 snRNA-encoding gene has an unusually compact structure

scientific article (publication date: 21 October 1992)

The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21

scientific article published on 4 December 2014

The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA ⬇️

scientific article published on November 7, 2011

The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction

scientific article

The hU3-55K protein requires 15.5K binding to the box B/C motif as well as flanking RNA elements for its association with the U3 small nucleolar RNA in Vitro

scientific article

The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease

scientific article

The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain

scientific article published on 12 January 2017

The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.

scientific article published on 18 February 2014

The spatial-functional coupling of box C/D and C'/D' RNPs is an evolutionarily conserved feature of the eukaryotic box C/D snoRNP nucleotide modification complex

scientific article published on November 2010

Unusual C΄/D΄ motifs enable box C/D snoRNPs to modify multiple sites in the same rRNA target region

scientific article published on February 2017

List of works by Nicholas J Watkins

A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP

A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation

Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex

Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing

Cbf5p, a potential pseudouridine synthase, and Nhp2p, a putative RNA-binding protein, are present together with Gar1p in all H BOX/ACA-motif snoRNPs and constitute a common bipartite structure.

Comparison of the yeast and human nuclear exosome complexes

Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP

Evidence that the AAA+ proteins TIP48 and TIP49 bridge interactions between 15.5K and the related NOP56 and NOP58 proteins during box C/D snoRNP biogenesis.

Functional analysis of the GTPases EngA and YhbZ encoded by Salmonella typhimurium.

In vitro assembly of the mouse U14 snoRNP core complex and identification of a 65-kDa box C/D-binding protein.

Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery

Interactions and activities of factors involved in the late stages of human 18S rRNA maturation

Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis

Minor spliceosome components are predominantly localized in the nucleus

Nucleolar disruption leads to the spatial separation of key 18S rRNA processing factors.

Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies

Processing of vertebrate box C/D small nucleolar RNAs in plant cells ⬇️

Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits

Protein-protein and protein-RNA contacts both contribute to the 15.5K-mediated assembly of the U4/U6 snRNP and the box C/D snoRNPs

Role of pre-rRNA base pairing and 80S complex formation in subnucleolar localization of the U3 snoRNP

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans

The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans

The U7 small nuclear RNA genes of Xenopus borealis

The Xenopus U7 snRNA-encoding gene has an unusually compact structure

The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21

The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA ⬇️

The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction

The hU3-55K protein requires 15.5K binding to the box B/C motif as well as flanking RNA elements for its association with the U3 small nucleolar RNA in Vitro

The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease

The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain

The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.

The spatial-functional coupling of box C/D and C'/D' RNPs is an evolutionarily conserved feature of the eukaryotic box C/D snoRNP nucleotide modification complex

Unusual C΄/D΄ motifs enable box C/D snoRNPs to modify multiple sites in the same rRNA target region