List of works - Hervé Le Hir

5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

scientific article

5'-End RET splicing: absence of variants in normal tissues and intron retention in pheochromocytomas.

scientific article published in January 2002

A UPF3-mediated regulatory switch that maintains RNA surveillance

scientific article published on 7 June 2009

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

scientific article published on 25 January 2018

A mechanistic study of helicases with magnetic traps

scientific article published on 5 May 2017

A novel rat tyrosine hydroxylase mRNA species generated by alternative splicing.

scientific article

Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module

scientific article

Biochemical characterization of the RNA helicase UPF1 involved in nonsense-mediated mRNA decay.

scientific article

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

scientific article published on 21 October 2012

CLIP-seq to discover transcriptome-wide imprinting of RNA binding proteins in living cells.

scientific article published in January 2015

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

scientific article

DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway

scientific article

EJC core component MLN51 interacts with eIF3 and activates translation ⬇️

scientific article published on March 25, 2013

Erratum to: Insights into the design and interpretation of iCLIP experiments.

scientific article published on 15 August 2017

Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events.

scientific article

Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development

scientific journal article

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

scientific article published on 30 January 2018

How introns influence and enhance eukaryotic gene expression

scientific article

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

scientific article

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities

scientific article

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

scientific article

Insights into the design and interpretation of iCLIP experiments

scientific article published on 16 January 2017

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex

scientific article

Mechanism of ATP turnover inhibition in the EJC

scientific article

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

scientific article

Monitored eCLIP: high accuracy mapping of RNA-protein interactions

Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies ⬇️

scientific article published on 6 March 2017

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

scientific article published on 9 December 2007

Nonsense-mediated mRNA decay inhibition by HTLV-1 Tax protein.

scientific article published on 7 January 2014

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

scientific article published on 01 October 2018

Perispeckles are major assembly sites for the exon junction core complex ⬇️

scientific article published on March 14, 2012

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions

scientific article

Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators

scientific article

Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas

scientific article published on 01 May 2000

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

scientific article

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

scientific article

The exon junction complex as a node of post-transcriptional networks

scientific article published on 16 December 2015

The exon junction complex differentially marks spliced junctions ⬇️

scientific article published on September 5, 2010

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

scientific article

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

scientific article

The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.

scientific article

The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.

scientific article

The protein Mago provides a link between splicing and mRNA localization.

scientific article

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

scientific article published on 28 December 2012

Transcriptome-wide identification of RNA binding sites by CLIP-seq ⬇️

scientific article published on March 30, 2013

Transcriptome-wide modulation of splicing by the exon junction complex

scientific article

UPF1-like helicase grip on nucleic acids dictates processivity

scientific article published in Nature Communications

List of works by Hervé Le Hir

5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

5'-End RET splicing: absence of variants in normal tissues and intron retention in pheochromocytomas.

A UPF3-mediated regulatory switch that maintains RNA surveillance

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

A mechanistic study of helicases with magnetic traps

A novel rat tyrosine hydroxylase mRNA species generated by alternative splicing.

Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module

Biochemical characterization of the RNA helicase UPF1 involved in nonsense-mediated mRNA decay.

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

CLIP-seq to discover transcriptome-wide imprinting of RNA binding proteins in living cells.

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway

EJC core component MLN51 interacts with eIF3 and activates translation ⬇️

Erratum to: Insights into the design and interpretation of iCLIP experiments.

Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events.

Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

How introns influence and enhance eukaryotic gene expression

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

Insights into the design and interpretation of iCLIP experiments

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex

Mechanism of ATP turnover inhibition in the EJC

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

Monitored eCLIP: high accuracy mapping of RNA-protein interactions

Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies ⬇️

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

Nonsense-mediated mRNA decay inhibition by HTLV-1 Tax protein.

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

Perispeckles are major assembly sites for the exon junction core complex ⬇️

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions

Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators

Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

The exon junction complex as a node of post-transcriptional networks

The exon junction complex differentially marks spliced junctions ⬇️

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.

The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.

The protein Mago provides a link between splicing and mRNA localization.

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

Transcriptome-wide identification of RNA binding sites by CLIP-seq ⬇️

Transcriptome-wide modulation of splicing by the exon junction complex

UPF1-like helicase grip on nucleic acids dictates processivity