List of works - Eefjan Breukink

A lesson in efficient killing from two-component lantibiotics

scientific article published on 12 June 2006

A novel in vivo cell-wall labeling approach sheds new light on peptidoglycan synthesis in Escherichia coli

scientific article published on 5 April 2011

A protein-based oxygen biosensor for high-throughput monitoring of cell growth and cell viability

scientific article

A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses

scientific article published on 23 February 2007

Activities and regulation of peptidoglycan synthases

scientific article

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.

scientific article

Assembly and stability of nisin-lipid II pores

scientific article published in September 2004

Calcium-dependent complex formation between PBP2 and lytic transglycosylase SltB1 of Pseudomonas aeruginosa

scientific article

Cell biology. Lethal traffic jam.

scientific article published in August 2009

Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms

scientific article

Cooperativity of peptidoglycan synthases active in bacterial cell elongation

scientific article

Correction: Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers

scientific article published in PLoS ONE

Elucidation of the antimicrobial mechanism of mutacin 1140.

scientific article published on 12 February 2008

Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides

scientific article

Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides

scientific article published on 14 April 2012

Expanding role of lipid II as a target for lantibiotics

scientific article published on October 2007

Fluorescent labeling of nisin Z and assessment of anti-listerial action

scientific article

Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II.

scientific article

Getting closer to the real bacterial cell wall target: biomolecular interactions of water-soluble lipid II with glycopeptide antibiotics

scientific article published in April 2003

High-resolution NMR studies of antibiotics in cellular membranes

scientific article published in Nature Communications

Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II.

scientific article

Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

scientific article

Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli

scientific article published on 13 August 2008

In vitro murein peptidoglycan synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli

scientific article

In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli

scientific article published on 13 July 2006

Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis

scientific article published in June 2008

Induced conformational changes activate the peptidoglycan synthase PBP1B

scholarly article by Alexander J. F. Egan published in October 2018

Influence of Charge Differences in the C‐Terminal Part of Nisin on Antimicrobial Activity and Signaling Capacity ⬇️

scientific article published on 01 July 1997

Interaction with lipid II induces conformational changes in bovicin HC5 structure

scientific article published on 11 June 2012

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

scientific article

Lipid II as a target for antibiotics

scientific article

Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin

scientific article published in October 2002

Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes

scientific article published on 26 March 2003

Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics

scientific article

Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation

scientific article published in July 2003

Mapping the targeted membrane pore formation mechanism by solution NMR: the nisin Z and lipid II interaction in SDS micelles

scientific article

Membrane interaction of the glycosyltransferase MurG: a special role for cardiolipin

scientific article

Membrane permeabilization by multivalent anti-microbial peptides

scientific article published on January 2009

Mode of action of teixobactins in cellular membranes

scientific article published on 05 June 2020

Molecular model for the solubilization of membranes into nanodisks by styrene maleic Acid copolymers

scientific article published in January 2015

NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity

scientific article (publication date: 11 April 2003)

Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane

scientific article published on 29 December 2007

Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol

scientific article published on 12 April 2010

New Insights into Nisin's Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues

scientific article

Optimization of conditions for the glycosyltransferase activity of penicillin-binding protein 1a from Thermotoga maritima

scientific article

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli

scientific article published on 03 February 2020

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

scholarly article by Niccolò Morè et al published 5 February 2019 in mBio

Plasticity of cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

scholarly article by Elizabeth A Mueller et al published 9 April 2019 in eLife

Polyene antibiotic that inhibits membrane transport proteins

scientific article

Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase

scientific article published on 14 November 2014

Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions.

scientific article

Publisher Correction: Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

scientific article published in Nature Communications

Reduction of Clostridium sporogenes spore outgrowth in natural sausage casings using nisin ⬇️

scientific article published on February 1, 2011

Regulation of peptidoglycan synthesis by outer-membrane proteins

scientific article published on December 2010

Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN

scientific article published in 2019

Resistance of Gram-positive bacteria to nisin is not determined by lipid II levels

scientific article published in October 2004

Role of lipid II and membrane thickness in the mechanism of action of the lantibiotic bovicin HC5.

scientific article published on 29 August 2011

SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli

scientific article published in 2020

Site-specific functionalization of proteins and their applications to therapeutic antibodies

scientific article

Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor

scientific article

Specific labeling of peptidoglycan precursors as a tool for bacterial cell wall studies

scientific article published on March 2009

Specificity of the transport of lipid II by FtsW in Escherichia coli

scientific article

Structural Motifs of Lipid II-Binding Lantibiotics as a Blueprint for Novel Antibiotics

article

Structure of the Peptidoglycan Synthase Activator LpoP in Pseudomonas aeruginosa

scientific article published on 09 April 2020

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

scientific article published in Nature Communications

Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase

scientific article published on 20 November 2015

Substitutions in PBP2b from β-Lactam-resistant Streptococcus pneumoniae Have Different Effects on Enzymatic Activity and Drug Reactivity

scientific article published on 6 January 2017

Synthesis and antifungal properties of papulacandin derivatives

scientific article published on 14 May 2012

Targeting extracellular pyrophosphates underpins the high selectivity of nisin

scientific article published in December 2004

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

scientific article published on 3 August 2022

The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in

scientific article published in 2018

The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets

scientific article

The Orientation of Nisin in Membranes ⬇️

scientific article published on June 2, 1998

The bacterial cell division protein fragment EFtsN binds to and activates the major peptidoglycan synthase PBP1b

scientific article published on 27 October 2020

The chlamydial anomaly clarified?

scientific article published on 02 June 2014

The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli

scientific article

The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length

scientific article

The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.

scientific article

The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics

scientific article

The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant Enterococci

scientific article

Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action

scientific article published on 24 March 2016

Towards the Native Binding Modes of Antibiotics that Target Lipid II

scientific article published on 22 May 2019

Transmembrane transport of peptidoglycan precursors across model and bacterial membranes

scientific article

Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

scientific article published in Nature Communications

List of works by Eefjan Breukink

A lesson in efficient killing from two-component lantibiotics

A novel in vivo cell-wall labeling approach sheds new light on peptidoglycan synthesis in Escherichia coli

A protein-based oxygen biosensor for high-throughput monitoring of cell growth and cell viability

A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses

Activities and regulation of peptidoglycan synthases

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.

Assembly and stability of nisin-lipid II pores

Calcium-dependent complex formation between PBP2 and lytic transglycosylase SltB1 of Pseudomonas aeruginosa

Cell biology. Lethal traffic jam.

Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms

Cooperativity of peptidoglycan synthases active in bacterial cell elongation

Correction: Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers

Elucidation of the antimicrobial mechanism of mutacin 1140.

Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides

Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides

Expanding role of lipid II as a target for lantibiotics

Fluorescent labeling of nisin Z and assessment of anti-listerial action

Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II.

Getting closer to the real bacterial cell wall target: biomolecular interactions of water-soluble lipid II with glycopeptide antibiotics

High-resolution NMR studies of antibiotics in cellular membranes

Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II.

Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane

Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli

In vitro murein peptidoglycan synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli

In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli

Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis

Induced conformational changes activate the peptidoglycan synthase PBP1B

Influence of Charge Differences in the C‐Terminal Part of Nisin on Antimicrobial Activity and Signaling Capacity ⬇️

Interaction with lipid II induces conformational changes in bovicin HC5 structure

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

Lipid II as a target for antibiotics

Lipid II induces a transmembrane orientation of the pore-forming peptide lantibiotic nisin

Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes

Lipid II: a central component in bacterial cell wall synthesis and a target for antibiotics

Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation

Mapping the targeted membrane pore formation mechanism by solution NMR: the nisin Z and lipid II interaction in SDS micelles

Membrane interaction of the glycosyltransferase MurG: a special role for cardiolipin

Membrane permeabilization by multivalent anti-microbial peptides

Mode of action of teixobactins in cellular membranes

Molecular model for the solubilization of membranes into nanodisks by styrene maleic Acid copolymers

NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity

Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane

Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol

New Insights into Nisin's Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues

Optimization of conditions for the glycosyltransferase activity of penicillin-binding protein 1a from Thermotoga maritima

Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli

Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

Plasticity of cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

Polyene antibiotic that inhibits membrane transport proteins

Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase

Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions.

Publisher Correction: Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

Reduction of Clostridium sporogenes spore outgrowth in natural sausage casings using nisin ⬇️

Regulation of peptidoglycan synthesis by outer-membrane proteins

Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN

Resistance of Gram-positive bacteria to nisin is not determined by lipid II levels

Role of lipid II and membrane thickness in the mechanism of action of the lantibiotic bovicin HC5.

SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli

Site-specific functionalization of proteins and their applications to therapeutic antibodies

Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor

Specific labeling of peptidoglycan precursors as a tool for bacterial cell wall studies

Specificity of the transport of lipid II by FtsW in Escherichia coli

Structural Motifs of Lipid II-Binding Lantibiotics as a Blueprint for Novel Antibiotics

Structure of the Peptidoglycan Synthase Activator LpoP in Pseudomonas aeruginosa

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase

Substitutions in PBP2b from β-Lactam-resistant Streptococcus pneumoniae Have Different Effects on Enzymatic Activity and Drug Reactivity

Synthesis and antifungal properties of papulacandin derivatives

Targeting extracellular pyrophosphates underpins the high selectivity of nisin

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in

The Membrane Steps of Bacterial Cell Wall Synthesis as Antibiotic Targets

The Orientation of Nisin in Membranes ⬇️

The bacterial cell division protein fragment EFtsN binds to and activates the major peptidoglycan synthase PBP1b

The chlamydial anomaly clarified?

The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli

The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length

The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.

The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics