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List of works by Jeremy Ryan

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

scientific article published on 17 November 2020

BCL2 suppresses PARP1 function and nonapoptotic cell death.

scientific article

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

scientific article published on 22 July 2019

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.

scientific article

BH3 profiling in whole cells by fluorimeter or FACS ⬇️

scientific article published on April 20, 2013

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals

scientific article published on 11 April 2008

Bcl-xL controls a switch between cell death modes during mitotic arrest

scientific article

Bcl-xL controls a switch between cell death modes during mitotic arrest.

scientific article

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

scientific article published on 15 April 2016

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

scientific article published on 05 February 2016

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

scientific article published on 23 July 2014

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

scientific article

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

scientific article

Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.

scientific article

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

scientific article

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

scientific article

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors

scientific article published on 16 June 2020

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.

scientific article

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

scientific article published on 02 August 2019

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199

scientific article

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

scientific article published on 01 June 2021

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

scientific article published on 28 August 2019

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

scientific article

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

scientific article published on 29 July 2019

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy ⬇️

scientific article published on October 27, 2011

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.

scientific article published on 8 February 2016

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

scientific article

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

scientific article published in December 2017

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

scientific article published on 23 June 2011

iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry

scientific article published on 23 February 2016

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