List of works by Michael B. Major

A circle RNA regulatory axis promotes lung squamous metastasis via CDR1-mediated regulation of Golgi trafficking

scientific article published on 25 September 2020

A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue

scientific article published on 03 July 2020

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

scientific article published on 05 July 2016

Approximating Isotope Distributions of Biomolecule Fragments

scientific article published on 19 September 2018

BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.

scientific article

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination

scientific article published on 09 December 2013

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53

scientific article

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer

scientific article published on 08 March 2018

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer

scientific article published on 06 April 2018

Distinct Wnt signaling pathways have opposing roles in appendage regeneration

scientific article published on 21 December 2006

Dynamics and evolution of β-catenin-dependent Wnt signaling revealed through massively parallel clonogenic screening.

scientific article

FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells.

scientific article published on 31 May 2013

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma.

scientific article

Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

scientific article published on 16 June 2020

Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo

scientific article

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

scientific article

Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus

scientific article published in Journal of Biological Chemistry

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate

scientific article published on 12 September 2016

Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta

scientific article (publication date: 13 February 2004)

Loss of SWI/SNF chromatin remodeling alters NRF2 signaling in non-small cell lung carcinoma

scientific article published on 27 August 2020

New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening

scientific article

PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

scientific article published on 28 September 2020

Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

scientific article published on 9 February 2018

Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer.

scientific article published on 26 July 2013

SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development.

scientific article

Small-molecule synergist of the Wnt/beta-catenin signaling pathway

scientific article

Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.

scientific article

Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase

scientific article

The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells

scientific article published in Scientific Reports

The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.

scientific article

The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes

scientific article published on 14 September 2019

The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase

scientific article

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

scientific article published on 09 May 2016

WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling

scientific article

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