Search filters

List of works by Sunil R. Lakhani

'Omics Approaches in Breast Cancer Research and Clinical Practice

scientific article published on November 2016

A Molecular and Morphological Deep-Dive Into Metaplastic Breast Cancers.

scientific article published on 17 May 2019

A multimedia psychosocial support program for couples receiving infertility treatment: a feasibility study

scientific article published on 01 March 2004

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

scientific article published on 22 May 2005

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

scientific article published on 23 January 2017

A test of performance of breast MRI interpretation in a multicentre screening study.

scientific article

Abstract 1980: Long-range regulation of HOTAIR identifies novel biomarkers of breast cancer outcome and suggests a role in genome instability

article

Abstract 32: Lynch syndrome-associated breast cancers: Clinicopathological characteristics of a case series from the Colon CFR

Abstract LB-116: Cep55, a master regulator of cytokinesis in breast cancer pathogenesis

Abstract P6-03-11: Erk5 as a therapeutic target in triple negative breast cancer (TNBC)

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

scientific article published on 6 December 2010

Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?

scientific article published on 19 March 2010

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Ca

scientific article published on 2 August 2017

Association analysis identifies 65 new breast cancer risk loci.

scientific article published on 23 October 2017

Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p.

scientific article published on July 1995

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article published on 01 February 2019

BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation

scientific article published on August 2003

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

scientific article

Basal-like breast carcinomas: clinical outcome and response to chemotherapy

scientific article published on 23 March 2006

Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival ⬇️

scientific article published on January 2007

Bayes analysis provides evidence of pathogenicity for the BRCA1 c.135-1G>T (IVS3-1) and BRCA2 c.7977-1G>C (IVS17-1) variants displaying in vitro splicing results of equivocal clinical significance

scientific article

Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases

scientific article published on 01 May 2020

Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context.

scientific article

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

scientific article published on 26 September 2016

Breast cancer metastasis to gynaecological organs: a clinico-pathological and molecular profiling study

Breast cancer prognostic classification in the molecular era: the role of histological grade

scientific article

Breast cancer special types: why bother?

scientific article published on December 2008

Breast cancer stem cells: treatment resistance and therapeutic opportunities

scientific article published on 10 February 2011

Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer

scientific article published on 24 March 2017

Breast pathology: beyond morphology

scientific article

CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation.

scientific article published on August 2001

COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment

scientific article

Can magnetic-resonance imaging help elucidate natural history of breast cancer multicentricity?

scientific article published on 01 March 1998

Can the stroma provide the clue to the cellular basis for mammographic density?

scientific article

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

scientific article published on 21 February 2018

Choroid plexus papillomas: immunohistochemical study

scientific article published in April 1990

Clinical Classification ofBRCA1andBRCA2DNA Sequence Variants: The Value of Cytokeratin Profiles and Evolutionary Analysis—A Report From the kConFab Investigators

article

Collagenous spherulosis in an adenomyoepithelioma of the breast

scientific article published on January 2004

Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis

scientific article

Comparative genomic hybridization analysis of bilateral hyperplasia of usual type of the breast

scientific article published on 01 February 2003

Comparative genomic hybridization analysis of myoepithelial carcinoma of the breast

scientific article

Comparative genomic hybridization reveals extensive variation among different MCF-7 cell stocks

scientific article published on March 2000

Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13.

scientific article

Correction: In Vitro Analysis of Breast Cancer Cell Line Tumourspheres and Primary Human Breast Epithelia Mammospheres Demonstrates Inter- and Intrasphere Heterogeneity

scientific article published on 3 July 2013

Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers

scientific article published in October 2017

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on May 2016

Cost-effectiveness of screening with contrast enhanced magnetic resonance imaging vs X-ray mammography of women at a high familial risk of breast cancer

scientific article published on October 2006

Current and future approach to the pathologist's assessment for targeted therapy in breast cancer

scientific article published on January 2009

Current topics in breast pathology: expert perspectives.

scientific article published on 6 January 2017

Cytokeratin 5/6 in normal human breast: lack of evidence for a stem cell phenotype.

scientific article

DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

scientific article

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

scientific article

Demystifying basal-like breast carcinomas

scientific article

Detection of allelic imbalance indicates that a proportion of mammary hyperplasia of usual type are clonal, neoplastic proliferations.

scientific article

Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity

scientific article

Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results.

scientific article published on April 2000

Digital spatial profiling application in breast cancer: a user's perspective

scientific article published on 26 May 2020

Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines

scientific article

Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue

scientific article published in March 2004

EGFR amplification and lack of activating mutations in metaplastic breast carcinomas

article

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

scientific article published on 19 March 2007

Environmental factors in breast cancer invasion: a mathematical modelling review

scientific article published on 9 January 2017

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

scientific article published on 02 May 2022

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis

scientific article

Evaluation of a prospective scoring system designed for a multicenter breast MR imaging screening study.

scientific article published in June 2006

Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

scientific article

Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast

scientific article published on November 2004

Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer

scientific article published in May 2004

FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas

scientific article published on November 2006

Fibroadenoma and intraduct papilloma--a common pathogenesis?

scientific article published on 11 August 2009

Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on 11 May 2015

Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay

scientific article

Genetic alterations in 'normal' luminal and myoepithelial cells of the breast

scientific article published on 01 December 1999

Genetic and Histopathologic Evaluation ofBRCA1andBRCA2DNA Sequence Variants of Unknown Clinical Significance

article

Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study ⬇️

scientific article published on 11 January 2018

Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast.

scientific article published on April 2004

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

scientific article

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

scientific article published on 13 March 2017

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

scientific article published on 06 September 2010

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines.

scientific article published on February 2015

High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations

scientific article published on 9 February 2016

High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers.

scientific article published on November 1999

How diagnosis with microarrays can help cancer patients

scientific article published in Nature

Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?

scientific article

Identification of the familial cylindromatosis tumour-suppressor gene

scientific article (publication date: June 2000)

Improving the reproducibility of the MCF-7 cell proliferation assay for the detection of xenoestrogens

scientific article

In situ carcinoma - can we predict which patient will come back with a recurrence?

scientific article published on 01 November 2007

In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity.

scientific article

In-situ lobular neoplasia: time for an awakening

scientific article published on 01 January 2003

Incorporating tumour pathology information into breast cancer risk prediction algorithms

scientific article

Introduction: the role of myoepithelial cells in integration of form and function in the mammary gland

scientific article published on 01 July 2005

Invasion in breast lesions: the role of the epithelial-stroma barrier

scientific article published on 2 December 2017

Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics

scientific article

Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer

scientific article

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Linkage and LOH studies in 19 cylindromatosis families show no evidence of genetic heterogeneity and refine the CYLD locus on chromosome 16q12-q13

article

Lobular carcinoma in situ of the breast is not caused by constitutional mutations in the E-cadherin gene

scientific article published on February 2000

Lobular carcinoma in situ: diagnostic criteria and molecular correlates

scientific article published on 06 October 2020

Lobular neoplasia of the breast revisited with emphasis on the role of E-cadherin immunohistochemistry

scientific article published on July 2013

Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer

scientific article published on 04 July 2016

Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours.

scientific article

Loss of heterozygosity in ductal carcinoma in situ of the breast.

scientific article published in February 1995

Loss of heterozygosity in lobular carcinoma in situ of the breast

scientific article

Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13.

scientific article

MR imaging of the skin and nipple of the breast: differentiation between tumour recurrence and post-treatment change

scientific article published on 01 January 2001

Malignant adenomyoepithelioma of the breast metastasizing to the liver

scientific article published on 12 April 2003

Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study

scientific article published on February 1995

Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project

scientific article published on 06 August 2018

Mapping loss of heterozygosity in normal human breast cells from BRCA1/2 carriers

scientific article published on August 2006

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

scientific article

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer.

scientific article

Metaplastic breast carcinomas are basal-like tumours

scientific article

Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis

scientific article

MicroRNA-182-5p targets a network of genes involved in DNA repair

scientific article

Microarray and histopathological analysis of tumours: the future and the past?

scientific article

Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology

scientific article published on 18 January 2018

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Molar tooth development in caspase-3 deficient mice.

scientific article published in January 2006

Molecular analyses of in situ breast cancer

scientific article published on 01 November 1993

Molecular analysis of phyllodes tumors reveals distinct changes in the epithelial and stromal components

scientific article published on March 2000

Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis.

scientific article published on 25 November 2008

Molecular aspects of breast cancer metastasis to the brain

scientific article published on 29 November 2011

Molecular classification of breast cancer

scientific article published on 31 May 2014

Molecular classification of breast cancer: is it time to pack up our microscopes?

scientific article published on January 2011

Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast

scientific article

Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes

scientific article

Molecular evidence for progression of microglandular adenosis (MGA) to invasive carcinoma.

scientific article published on April 2009

Molecular evolution of breast cancer

scientific article

Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas

scientific article published in July 2008

Morphologic and Genomic Heterogeneity in the Evolution and Progression of Breast Cancer

scientific article published on 31 March 2020

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

scientific article

Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations

scientific article published in August 1998

Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation

scientific article published on 28 January 2014

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013

Mutation analysis of five candidate genes in familial breast cancer

scientific article

Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women

scientific article published on 7 December 2013

Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation

scientific article published on July 2005

Natural sunscreen revealed

scientific article published on 01 December 2001

Next-Generation Sequencing of Endobronchial Ultrasound Transbronchial Needle Aspiration Specimens in Lung Cancer.

scientific article published in August 2017

Observer agreement comparing the use of virtual slides with glass slides in the pathology review component of the POSH breast cancer cohort study

scientific article published on 23 March 2012

Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer

scientific article published on December 2004

Papillary and neuroendocrine breast lesions: the WHO stance

scientific article published on 23 January 2015

Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma

scientific article published in September 2003

Pathology of hereditary breast cancer

scientific article published on May 2010

Pathology of ovarian cancers in BRCA1 and BRCA2 carriers

scientific article published on April 2004

Phenotype-genotype correlation in familial breast cancer

scientific article published on 12 March 2011

Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications

Phyllodes tumours of the breast: a consensus review

scientific article

Pleomorphic lobular carcinoma of the breast: molecular pathology and clinical impact.

scientific article published on March 2009

Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity

scholarly article by Jorge Reis-Filho et al published 2005 in Journal of Pathology

Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype

scientific article published on July 2005

Profiling copy number alterations in cell-free tumour DNA using a single-reference

Profiling familial breast cancer

scientific article published on 01 April 2001

Progesterone receptor-positive eruptive syringoma associated with diabetes.

scientific article published in May 2003

Proliferation and differentiation in the human breast during pregnancy

scientific article published on 01 October 2000

Putting the brakes on cylindromatosis?

scientific article (publication date: 8 January 2004)

Rad51 supports triple negative breast cancer metastasis

scientific article published in May 2014

Rare variants in the ATM gene and risk of breast cancer

scientific article published on 25 July 2011

Reading protocol for dynamic contrast-enhanced MR images of the breast: sensitivity and specificity analysis

scientific article published in September 2005

Recent advances in breast cancer research impacting clinical diagnostic practice

scientific article published on 16 January 2019

Relationship of the Breast Ductal Carcinoma In Situ Immune Microenvironment with Clinicopathological and Genetic Features

scientific article published on 13 June 2017

Role of the executioner caspases during lens development.

scientific article published on 30 June 2005

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

scientific article

Salivary gland-like tumours of the breast: surgical and molecular pathology

scientific article

Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS).

scientific article published in May 2005

Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

Signatures of mutational processes in human cancer

scientific article (publication date: 22 August 2013)

Somatic mutations of the protein kinase gene family in human lung cancer

scientific article published on September 2005

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

scientific article

Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast

scientific article published on July 2006

Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary

scientific article

Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group

scientific article published on July 2016

Subtypes of familial breast tumours revealed by expression and copy number profiling

scientific article

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia.

scientific article

The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS)

scientific article published on 01 September 2002

The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours

scientific article published on 01 April 2002

The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.

scientific article

The cancer genetics and pathology of male breast cancer

scientific article

The contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriers

scientific article published on December 2010

The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas

scientific article

The diagnosis and management of pre-invasive breast disease Genetic alterations in pre-invasive lesions ⬇️

scientific article published on October 9, 2003

The diagnosis and management of pre-invasive breast disease--current challenges, future hopes

scientific article

The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ

scientific article

The expression patterns of integrin subunits on human breast tissues obtained during pregnancy

scientific article

The inframammary fold: contents, clinical significance and implications for immediate breast reconstruction

scientific article published on 01 March 2004

The landscape of cancer genes and mutational processes in breast cancer

scientific article (publication date: 16 May 2012)

The mammary myoepithelial cell--Cinderella or ugly sister?

scientific article

The management of lobular carcinoma in situ (LCIS). Is LCIS the same as ductal carcinoma in situ (DCIS)?

scientific article published on 28 July 2006

The molecular genetics of breast cancer: the contribution of comparative genomic hybridization

scientific article

The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2

scientific article published on 01 March 2000

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

scientific article published in May 2002

The teaching of pathology at St. George's Hospital Medical School, London

scientific article published on 01 June 1990

The topography of mutational processes in breast cancer genomes

scientific article published on 02 May 2016

Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

scientific article published on 18 May 2020

Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

scientific article published on 5 April 2013

Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridization

scientific article published on 01 June 2011

Typical medullary breast carcinomas have a basal/myoepithelial phenotype.

scientific article published on November 2005

What's in a cancer syndrome? Genes, phenotype and pathology

scientific article published on April 2008

X-inactivation patch size in human female tissue confounds the assessment of tumor clonality

scholarly article

cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells

scientific article published on May 2003

miR-139-5p is a regulator of metastatic pathways in breast cancer

scientific article published on 24 October 2013

Paulina is supported by:

About Paulina

Help