List of works - Serena Carra

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism.

scientific article published on 25 August 2016

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases

scientific article published on 16 October 2010

Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.

scientific article published on August 2017

Abnormal interaction of motor neuropathy-associated mutant HspB8 (Hsp22) forms with the RNA helicase Ddx20 (gemin3).

scientific article

Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins.

scientific article published on 29 September 2011

Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function

scientific article

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

scientific article published on 4 April 2017

An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.

scientific article

Autophagy researchers

BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes

scientific article published on 21 July 2020

BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity

scientific article

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.

scientific article

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

scientific article published on April 2014

Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor

scientific article published in December 2004

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.

scientific article published on 28 June 2013

Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain

scientific article published on March 2003

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

scientific article published on 04 July 2019

Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders.

scientific article published on 25 March 2013

Differential autophagy power in the spinal cord and muscle of transgenic ALS mice.

scientific article

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins.

scientific article published on 05 August 2011

Granulostasis: Protein Quality Control of RNP Granules ⬇️

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones ⬇️

scientific article published on September 15, 2010

Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

scientific article published on 19 March 2021

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

scientific article published on 15 November 2007

HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation

scientific article published on 29 December 2008

HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells.

scientific article published on 6 May 2005

Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.

scientific article

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

scientific article published on 18 July 2014

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.

scientific article published on 12 April 2017

Modulation of glutamate receptors in response to the novel antipsychotic olanzapine in rats

scientific article published in July 2001

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

scientific article published on 26 August 2019

Small heat shock proteins, protein degradation and protein aggregation diseases.

scientific article published in January 2011

Small heat shock proteins: multifaceted proteins with important implications for life

scientific article published on 13 February 2019

Specific protein homeostatic functions of small heat-shock proteins increase lifespan.

scientific article published on 25 December 2015

Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families.

scientific article published on 17 June 2008

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases.

scientific article published in February 2012

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.

scientific article

The Role of the Protein Quality Control System in SBMA.

scientific article

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.

scientific article published on 27 July 2016

The growing world of small heat shock proteins: from structure to functions

scientific article published on 31 March 2017

The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

scientific article published on 12 April 2021

The regulation of the autophagic network and its implications for human disease

scientific article

The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases.

scientific article published on 12 June 2017

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells

scientific article published on 02 January 2017

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

scientific article published on 22 June 2010

The stress-inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: implications for protein quality control and viral factory degradation?

scientific article published on 21 April 2009

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

scientific article published on 10 March 2016

List of works by Serena Carra

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism.

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases

Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.

Abnormal interaction of motor neuropathy-associated mutant HspB8 (Hsp22) forms with the RNA helicase Ddx20 (gemin3).

Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins.

Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.

Autophagy researchers

BAG3 and BAG6 differentially affect the dynamics of stress granules by targeting distinct subsets of defective polypeptides released from ribosomes

BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.

Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders.

Differential autophagy power in the spinal cord and muscle of transgenic ALS mice.

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins.

Granulostasis: Protein Quality Control of RNP Granules ⬇️

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones ⬇️

Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation

HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells.

Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases.

Modulation of glutamate receptors in response to the novel antipsychotic olanzapine in rats

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

Small heat shock proteins, protein degradation and protein aggregation diseases.

Small heat shock proteins: multifaceted proteins with important implications for life

Specific protein homeostatic functions of small heat-shock proteins increase lifespan.

Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families.

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases.

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.

The Role of the Protein Quality Control System in SBMA.

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.

The growing world of small heat shock proteins: from structure to functions

The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones

The regulation of the autophagic network and its implications for human disease

The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases.

The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

The stress-inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: implications for protein quality control and viral factory degradation?

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases