List of works - Peter Liljeström

A 6K-deletion variant of salmonid alphavirus is non-viable but can be rescued through RNA recombination.

scientific article

A novel poxvirus-based vaccine, MVA-CHIKV, is highly immunogenic and protects mice against chikungunya infection.

scientific article published on 08 January 2014

A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens.

scientific article published in August 2000

Alphavirus expression vectors and their use as recombinant vaccines: a minireview.

scientific article published on April 1997

Alphavirus replicon DNA expressing HIV antigens is an excellent prime for boosting with recombinant modified vaccinia Ankara (MVA) or with HIV gp140 protein antigen.

scientific article

An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses

scientific article

Aromatic interactions define the binding of the alphavirus spike to its nucleocapsid

scientific article published on 01 May 1996

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus

scientific article published on 23 March 2017

Budding of enveloped viruses from the plasma membrane.

scientific article published in November 1997

Comparative prime-boost vaccinations using Semliki Forest virus, adenovirus, and ALVAC vectors demonstrate differences in the generation of a protective central memory CTL response against the P815 tumor.

scientific article published on June 2007

Comparison of the efficacy of early versus late viral proteins in vaccination against SIV

scientific article published on 01 July 2002

Competition Between CTL Narrows the Immune Response Induced by Prime-Boost Vaccination Protocols

scientific article published in May 2002

DNA immunization followed by a viral vector booster in a Chlamydia pneumoniae mouse model.

scientific article published on September 2004

De-novo transcriptome sequencing of a normalized cDNA pool from influenza infected ferrets.

scientific article

Delivery and expression of heterologous genes in mammalian cells using self-replicating alphavirus vectors.

scientific article published on January 2004

Distinct Immunogenicity and Efficacy of Poxvirus-based Vaccine Candidates against Ebola Virus expressing GP and VP40 Proteins

scientific article published on 7 March 2018

EV01: a phase I trial in healthy HIV negative volunteers to evaluate a clade C HIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium.

scientific article

Efficient expansion of HIV-1-specific T cell responses by homologous immunization with recombinant Semliki Forest virus particles.

scientific article published on 10 August 2005

Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara.

scientific article published in May 2001

Enhancing immune responses using suicidal DNA vaccines.

scientific article published on June 1998

Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C

scientific article published on 06 December 2006

Generation of cytotoxic and humoral immune responses by nonreplicative recombinant Semliki Forest virus.

scientific article

Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B.

scientific article published on 16 October 2006

Humoral responses against coimmunized protein antigen but not against alphavirus-encoded antigens require alpha/beta interferon signaling

scientific article

Immunotherapy with recombinant SFV-replicons expressing the P815A tumor antigen or IL-12 induces tumor regression.

scientific article published on April 2002

Intradermal Electroporation of RNA

scientific article published on 01 January 2014

Intradermal electroporation of naked replicon RNA elicits strong immune responses

scientific article (publication date: 2012)

Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations

scientific article

Live viral vectors: Semliki Forest virus.

scientific article published on January 2003

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

scientific article

Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo.

scientific article published in April 2003

Modification of a salmonid alphavirus replicon vector for enhanced expression of heterologous antigens

scientific article

Modulation of vaccine-induced immune responses to hepatitis C virus in rhesus macaques by altering priming before adenovirus boosting

scientific article published in August 2005

MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells.

scientific article

Non-viral amplification systems for gene transfer: vectors based on alphaviruses.

scientific article

Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus.

scientific article published in November 1997

Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV

scientific article published on 21 March 2019

Potent therapeutic efficacy of an alphavirus replicon DNA vaccine expressing human papilloma virus E6 and E7 antigens

scientific article published on 26 July 2018

Prime-boost immunization strategies against Chikungunya virus

scientific article

Protective efficacy of a multicomponent vector vaccine in cynomolgus monkeys after intrarectal simian immunodeficiency virus challenge

scientific article published in May 2004

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

scientific article (publication date: 10 November 2006)

Recombinant Semliki Forest virus particles encoding the prME or NS1 proteins of louping ill virus protect mice from lethal challenge.

scientific article published in May 1999

Recombinant Semliki Forest virus vaccine vectors: the route of injection determines the localization of vector RNA and subsequent T cell response.

scientific article

Reversible Acid-Induced Inactivation of the Membrane Fusion Protein of Semliki Forest Virus

scientific article (publication date: June 2005)

Role of innate signalling pathways in the immunogenicity of alphaviral replicon-based vaccines

scientific article

Role of the C-terminal tryptophan residue for the structure-function of the alphavirus capsid protein.

scientific article published in June 1998

Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02).

scientific article published on 09 September 2011

Self-replicating alphavirus RNA vaccines.

scientific article published on October 2014

Semliki Forest virus produced in the absence of the 6K protein has an altered spike structure as revealed by decreased membrane fusion capacity.

scientific article published on August 2004

Semliki Forest virus-based vaccines: persistence, distribution and pathological analysis in two animal systems.

scientific article published in February 2001

Suppressors of Cleavage-Site Mutations in the p62 Envelope Protein of Semliki Forest Virus Reveal Dynamics in Spike Structure and Function ⬇️

scientific article published on April 1, 1998

T-cell-mediated protective efficacy of a systemic vaccine approach in cynomolgus monkeys after SIV mucosal challenge.

scientific article published in October 2004

The 6-kilodalton membrane protein of Semliki Forest virus is involved in the budding process

scientific article

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

scientific article

Two-helper RNA system for production of recombinant Semliki forest virus particles.

scientific article published on February 1999

Use of conventional or replicating nucleic acid-based vaccines and recombinant Semliki forest virus-derived particles for the induction of immune responses against hepatitis C virus core and E2 antigens.

scientific article published in October 2000

Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens.

scientific article published in October 2004

Viral vectors for malaria vaccine development

scientific article published on August 2006

List of works by Peter Liljeström

A 6K-deletion variant of salmonid alphavirus is non-viable but can be rescued through RNA recombination.

A novel poxvirus-based vaccine, MVA-CHIKV, is highly immunogenic and protects mice against chikungunya infection.

A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens.

Alphavirus expression vectors and their use as recombinant vaccines: a minireview.

Alphavirus replicon DNA expressing HIV antigens is an excellent prime for boosting with recombinant modified vaccinia Ankara (MVA) or with HIV gp140 protein antigen.

An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses

Aromatic interactions define the binding of the alphavirus spike to its nucleocapsid

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus

Budding of enveloped viruses from the plasma membrane.

Comparative prime-boost vaccinations using Semliki Forest virus, adenovirus, and ALVAC vectors demonstrate differences in the generation of a protective central memory CTL response against the P815 tumor.

Comparison of the efficacy of early versus late viral proteins in vaccination against SIV

Competition Between CTL Narrows the Immune Response Induced by Prime-Boost Vaccination Protocols

DNA immunization followed by a viral vector booster in a Chlamydia pneumoniae mouse model.

De-novo transcriptome sequencing of a normalized cDNA pool from influenza infected ferrets.

Delivery and expression of heterologous genes in mammalian cells using self-replicating alphavirus vectors.

Distinct Immunogenicity and Efficacy of Poxvirus-based Vaccine Candidates against Ebola Virus expressing GP and VP40 Proteins

EV01: a phase I trial in healthy HIV negative volunteers to evaluate a clade C HIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium.

Efficient expansion of HIV-1-specific T cell responses by homologous immunization with recombinant Semliki Forest virus particles.

Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara.

Enhancing immune responses using suicidal DNA vaccines.

Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C

Generation of cytotoxic and humoral immune responses by nonreplicative recombinant Semliki Forest virus.

Head-to-head comparison on the immunogenicity of two HIV/AIDS vaccine candidates based on the attenuated poxvirus strains MVA and NYVAC co-expressing in a single locus the HIV-1BX08 gp120 and HIV-1(IIIB) Gag-Pol-Nef proteins of clade B.

Humoral responses against coimmunized protein antigen but not against alphavirus-encoded antigens require alpha/beta interferon signaling

Immunotherapy with recombinant SFV-replicons expressing the P815A tumor antigen or IL-12 induces tumor regression.

Intradermal Electroporation of RNA

Intradermal electroporation of naked replicon RNA elicits strong immune responses

Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations

Live viral vectors: Semliki Forest virus.

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo.

Modification of a salmonid alphavirus replicon vector for enhanced expression of heterologous antigens

Modulation of vaccine-induced immune responses to hepatitis C virus in rhesus macaques by altering priming before adenovirus boosting

MyD88 expression is required for efficient cross-presentation of viral antigens from infected cells.

Non-viral amplification systems for gene transfer: vectors based on alphaviruses.

Outcome of immunization of cynomolgus monkeys with recombinant Semliki Forest virus encoding human immunodeficiency virus type 1 envelope protein and challenge with a high dose of SHIV-4 virus.

Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV

Potent therapeutic efficacy of an alphavirus replicon DNA vaccine expressing human papilloma virus E6 and E7 antigens

Prime-boost immunization strategies against Chikungunya virus

Protective efficacy of a multicomponent vector vaccine in cynomolgus monkeys after intrarectal simian immunodeficiency virus challenge

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

Recombinant Semliki Forest virus particles encoding the prME or NS1 proteins of louping ill virus protect mice from lethal challenge.

Recombinant Semliki Forest virus vaccine vectors: the route of injection determines the localization of vector RNA and subsequent T cell response.

Reversible Acid-Induced Inactivation of the Membrane Fusion Protein of Semliki Forest Virus

Role of innate signalling pathways in the immunogenicity of alphaviral replicon-based vaccines

Role of the C-terminal tryptophan residue for the structure-function of the alphavirus capsid protein.

Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02).

Self-replicating alphavirus RNA vaccines.

Semliki Forest virus produced in the absence of the 6K protein has an altered spike structure as revealed by decreased membrane fusion capacity.

Semliki Forest virus-based vaccines: persistence, distribution and pathological analysis in two animal systems.

Suppressors of Cleavage-Site Mutations in the p62 Envelope Protein of Semliki Forest Virus Reveal Dynamics in Spike Structure and Function ⬇️

T-cell-mediated protective efficacy of a systemic vaccine approach in cynomolgus monkeys after SIV mucosal challenge.

The 6-kilodalton membrane protein of Semliki Forest virus is involved in the budding process

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

Two-helper RNA system for production of recombinant Semliki forest virus particles.

Use of conventional or replicating nucleic acid-based vaccines and recombinant Semliki forest virus-derived particles for the induction of immune responses against hepatitis C virus core and E2 antigens.

Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens.

Viral vectors for malaria vaccine development