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List of works by Jose M Polo

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

scientific article

A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells

scientific article published on 18 February 2016

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters

scientific article published on August 2013

A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

scientific article published on 15 June 2018

A molecular roadmap of reprogramming somatic cells into iPS cells

scientific article published on December 2012

A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells.

scientific article

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

scientific article published on 16 October 2008

A predictive computational framework for direct reprogramming between human cell types

scientific article

A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation

scientific article published on 01 December 2019

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation.

scientific article

Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity

scientific article

An improved reprogrammable mouse model harbouring the reverse tetracycline-controlled transcriptional transactivator 3.

scientific article published on 25 May 2016

B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma.

scientific article published on July 2008

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

scientific article published on 29 March 2022

BCL6 is critical for the development of a diverse primary B cell repertoire

scientific article

BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt.

scientific article published on 23 October 2009

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

scientific article

BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner.

scientific article

Breaking constraint of mammalian axial formulae

scientific article published on 11 January 2022

Cell Type of Origin Dictates the Route to Pluripotency.

scientific article published in December 2017

Cell surface marker mediated purification of iPS cell intermediates from a reprogrammable mouse model.

scientific article published on 6 September 2014

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

scientific article (publication date: August 2010)

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming

scientific article published on 25 September 2017

Computational methods for direct cell conversion

scientific article

DEAD-Box RNA Binding Protein DDX5: Not a Black-Box during Reprogramming.

scientific article published in April 2017

Epigenetic memory in somatic cell nuclear transfer and induced pluripotency: evidence and implications

scientific article published on July 2014

Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation Of Pluripotent Stem Cells Independent of β-Catenin-Mediated TCF Signaling

scientific article

GM-CSF and MEF-conditioned media support feeder-free reprogramming of mouse granulocytes to iPS cells.

scientific article published on June 2014

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming

scientific article published on 9 May 2013

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

scientific article

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1.

scientific article published on 13 August 2014

Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency

scientific article published on December 2012

Identification of dynamic undifferentiated cell states within the male germline

scientific article published in Nature Communications

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

scientific article

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

scientific article published on 17 April 2011

Isolation of Reprogramming Intermediates During Generation of Induced Pluripotent Stem Cells from Mouse Embryonic Fibroblasts.

scientific article published in January 2015

Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells.

scientific article published on April 2013

Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest

scientific article published in July 2017

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

scientific article

Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells

scientific article published on 11 May 2021

Phases of reprogramming

scientific article published on April 2014

Reprogramming can be a transforming experience

scientific article published in March 2014

SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells

scientific article

SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program.

scientific article published on 9 May 2018

Sequential transcription factor targeting for diffuse large B-cell lymphomas

scientific article

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

scientific article published on 10 March 2015

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice ⬇️

scientific article published on October 4, 2011

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells

scientific article published on 7 November 2004

TFAP2C regulates transcription in human naive pluripotency by opening enhancers.

scientific article

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

scientific article published on 23 March 2009

The application of human pluripotent stem cells to model the neuronal and glial components of neurodevelopmental disorders

scientific article published on 27 August 2019

Towards understanding transcriptional networks in cellular reprogramming.

scientific article

Transcription factor-mediated reprogramming: epigenetics and therapeutic potential

scientific article

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

scientific article published on 21 May 2021

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas.

scholarly article

Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming

scientific article published in December 2017

When fibroblasts MET iPSCs

scientific article published on 17 June 2010

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