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List of works by Iain A McNeish

<scp>PTEN</scp> deficiency exposes a requirement for an <scp>ARF GTPase</scp> module for integrin‐dependent invasion in ovarian cancer

scientific article published in 2023

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

article

A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor.

scientific article

A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.

scientific article published on 18 March 2014

A randomised, placebo-controlled trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer†.

scientific article published on 28 July 2014

A statement for extensive primary cytoreductive surgery in advanced ovarian cancer

scientific article published on 01 June 2008

Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer

scientific article published on 20 December 2017

Activity of the adenoviral E1A deletion mutant dl922-947 in ovarian cancer: comparison with E1A wild-type viruses, bioluminescence monitoring, and intraperitoneal delivery in icodextrin.

scientific article published in January 2006

Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.

scientific article published on 4 September 2017

Are rigid management protocols stifling innovation in cancer treatment?

article

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer.

scientific article published on June 2010

Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours.

scientific article

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer

scientific article published on 21 June 2016

Author Correction: CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity.

scientific article published on 13 April 2018

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers

scientific article

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma

scientific article published on 16 August 2016

CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity

scientific article published on 4 December 2017

Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo.

scientific article published on May 2006

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

scientific article published on 01 July 2021

Characterization of a <i>RAD51C</i>-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance

scientific article published on 09 July 2021

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer

scientific article published on 22 September 2015

Clear cell carcinoma of ovary and uterus.

scientific article published on December 2013

Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

scientific article published on 19 June 2015

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC).

scientific article

Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer

scientific article

Copy number signatures and mutational processes in ovarian carcinoma

scientific article published on 13 August 2018

Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers

scientific article published on 03 November 2020

Current academic clinical trials in ovarian cancer: Gynecologic Cancer Intergroup and US National Cancer Institute Clinical Trials Planning Meeting, May 2009

scientific article

Defining the surgical management of suspected early-stage ovarian cancer by estimating patient numbers through alternative management strategies.

scientific article published on 28 May 2009

Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE)

scientific article published on 17 June 2020

Doppler ultrasonography of the uterine artery and the response to chemotherapy in patients with gestational trophoblastic tumors.

scientific article

Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.

scientific article published on 03 July 2013

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

scientific article published on 19 January 2017

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk

scientific article

Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study

scientific article published on 17 December 2014

Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway

scientific article (publication date: 10 June 2003)

Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy

scientific article published on 01 June 2007

Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in vitro and in vivo.

scientific article

Fibroblast Growth Factor 2-Mediated Translational Control of IAPs Blocks Mitochondrial Release of Smac/DIABLO and Apoptosis in Small Cell Lung Cancer Cells.

scientific article published in August 2004

Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

scientific article

Fifth Ovarian Cancer Consensus Conference: individualized therapy and patient factors

scientific article published on 24 January 2017

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

scientific article published on 7 September 2016

Gene directed enzyme prodrug therapy for cancer.

scientific article published in July 1997

Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes.

scientific article published on March 2004

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

scientific article published on 17 December 2018

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

scientific article published in September 2016

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

scientific article

Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary

scientific article

Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions

scientific article published on 26 February 2019

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

scientific article

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

scientific article published on 12 January 2015

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

scientific article published on 15 April 2009

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration

scientific article published on July 2016

Inhibition of the inflammatory cytokine TNF-α increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression

scientific article

Interleukin-6 as a therapeutic target in human ovarian cancer

scientific article

Lister strain vaccinia virus with thymidine kinase gene deletion is a tractable platform for development of a new generation of oncolytic virus.

scientific article

Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer

scientific article published on August 23, 2010

Low-risk persistent gestational trophoblastic disease: outcome after initial treatment with low-dose methotrexate and folinic acid from 1992 to 2000.

scientific article published in April 2002

Malignant ovarian germ cell tumors: identification of novel prognostic markers and long-term outcome after multimodality treatment

scientific article published on 01 October 2006

Methanol-based fixation is superior to buffered formalin for next-generation sequencing of DNA from clinical cancer samples.

scientific article published on 17 December 2015

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

scientific article published in Nature Communications

Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma.

scientific article published in June 2016

Neoantigens in Ovarian Cancer: Embarrassment of Riches or Needles in a Haystack?

scientific article published on 06 July 2018

Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk

scientific article

No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival

scientific article published on 27 September 2016

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

scientific article published in May 2015

Nuclear survivin abrogates multiple cell cycle checkpoints and enhances viral oncolysis.

scientific article published in October 2008

Oncologist-led BRCA 'mainstreaming' in the ovarian cancer clinic: A study of 255 patients and its impact on their management

scientific article published on 25 February 2020

Oncolytic adenoviral gene therapy in ovarian cancer: why we are not wasting our time

scientific article published on April 2009

Oncolytic virus-induced cell death and immunity: a match made in heaven?

scientific article

PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS

scientific article published in December 2016

Paclitaxel induces immunogenic cell death in ovarian cancer via TLR4/IKK2/SNARE-dependent exocytosis

scientific article published on 30 April 2020

Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control.

scientific article

Paclitaxel-containing high-dose chemotherapy for relapsed or refractory testicular germ cell tumours.

scientific article published on March 2004

Paraneoplastic thrombocytosis in ovarian cancer.

scientific article published on February 2012

Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity.

scientific article published on 14 May 2015

Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck.

scientific article

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer

scientific article

Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer.

scientific article published on 14 March 2011

Predictors of pretreatment CA125 at ovarian cancer diagnosis: a pooled analysis in the Ovarian Cancer Association Consortium

scientific article published on 3 January 2017

Primary chemotherapy for inoperable ovarian, fallopian tube, or primary peritoneal cancer with or without delayed debulking surgery

scientific article published on 01 May 2012

Primary site assignment in tubo-ovarian high-grade serous carcinoma: Consensus statement on unifying practice worldwide

scientific article published on 28 January 2016

Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.

scientific article published on March 2001

Prognostic pathways in early-stage ovarian cancer: can gene expression transcend histological subtype?

scientific article published on 29 June 2016

Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy.

scientific article

Prophylactic In Vivo Hematopoietic Stem Cell Gene Therapy with an Immune Checkpoint Inhibitor Reverses Tumor Growth in Syngeneic Mouse Tumor Models

scientific article published on 14 November 2019

Quantifying the activity of adenoviral E1A CR2 deletion mutants using renilla luciferase bioluminescence and 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography imaging.

scientific article published on September 2006

RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer

scientific article

RIPK3 promotes adenovirus type 5 activity

scientific article

Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer.

scientific article

Reducing incidence of headache after lumbar puncture and intrathecal cytotoxics

scientific article published on 01 June 1999

Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: test-retest measurements for tumor FDG uptake, diameter, and volume.

scientific article published on 26 February 2014

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

scientific article

Rethinking ovarian cancer: recommendations for improving outcomes

scientific article

Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

scientific article published on 13 November 2018

Role of molecular agents and targeted therapy in clinical trials for women with ovarian cancer.

scientific article published on May 2011

Routine germline BRCA1 and BRCA2 testing in ovarian carcinoma patients: analysis of the Scottish real life experience

scientific article published on 20 February 2018

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

scientific article published on 28 November 2016

Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial

scientific article published on 12 September 2017

Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium.

scientific article

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

scientific article published on 6 June 2017

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

scientific article published on 15 February 2017

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

scientific article

Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium.

scientific article

Structural Variants at the <i>BRCA1/2</i> Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma

scientific article published on 19 March 2021

Survivin: a protein with dual roles in mitosis and apoptosis

scientific article

Targeted anti-vascular therapies for ovarian cancer: current evidence

scientific article

Targeting DNA repair: the genome as a potential biomarker.

scientific article published on 27 December 2017

The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma.

scientific article published on 27 September 2017

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

scientific article published on 2 March 2016

The intracellular uptake of CD95 modified paclitaxel-loaded poly(lactic-co-glycolic acid) microparticles.

scientific article

The peritoneal tumour microenvironment of high-grade serous ovarian cancer.

scientific article published on 18 April 2012

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

scientific article

Twenty-five years' clinical experience with placental site trophoblastic tumors.

scientific article

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

scientific article published in PLoS ONE

Visualization of cardiac emboli from mitral valve papillary fibroelastoma

scientific article published on 01 June 1996

p21 Promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker

scientific article

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

scientific article published on 21 August 2018