List of works - Yardena Samuels

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma

scientific article published on 10 October 2019

A growing family: adding mutated Erbb4 as a novel cancer target

scientific article

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

scientific article

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

scientific article published on 29 March 2009

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

scientific article

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

scientific article published on 01 August 1998

Colorectal cancer: mutations in a signalling pathway

scientific article published in August 2005

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

article

Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells.

scientific article published on 27 November 2017

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma ⬇️

scientific article published on September 24, 2012

Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells

scientific article published on 26 March 2019

Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.

scientific article

Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.

scientific article

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

scientific article

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

scientific article

Frequent mutations in the MITF pathway in melanoma

scientific article published on 29 April 2009

Genetic and Functional Analysis of GRIN2A in Tumor Samples.

scientific article

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

scientific article

High frequency of mutations of the PIK3CA gene in human cancers

scientific article (publication date: 23 April 2004)

IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain

scientific article

MEK inhibition reverses aberrant signaling in melanoma cells through reorganization of NRas and BRAF in self nano-clusters

scientific article published on 21 December 2020

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

scientific article

Molecular Pathways: Dysregulated Glutamatergic Signaling Pathways in Cancer ⬇️

scientific article published on May 30, 2012

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

scientific article published on June 2005

Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.

scientific article

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma

scientific article

Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma

scientific article

Mutational inactivation of STAG2 causes aneuploidy in human cancer

scientific article

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

scientific article published on 20 June 2016

Oncogenic mutations of PIK3CA in human cancers

scientific article published on 12 October 2004

Parkin Somatic Mutations Link Melanoma and Parkinson's Disease

scientific article

Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma

scientific article published on 13 April 2016

RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

scientific article published on 12 January 2018

Recurrent inactivating RASA2 mutations in melanoma

scientific article published on 26 October 2015

Refinement of the Endogenous Epitope Tagging (EET) Technology Allows the Identification of a Novel NRAS Binding Partner in Melanoma.

scientific article published on 17 April 2018

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms

scientific article published on 26 July 2006

Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA

article

Shimmer: detection of genetic alterations in tumors using next-generation sequence data

scientific article

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

scientific article

Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin

scientific article

Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications.

scientific article published on 27 December 2016

TYRO3-mediated regulation of MITF: a novel target in melanoma?

scientific article

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

scientific article published in February 2018

The functional relevance of somatic synonymous mutations in melanoma and other cancers

scientific article published on 24 August 2015

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

scientific article

Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens.

scientific article published on 20 January 2016

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

scientific article published on 30 July 2013

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

scientific article

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

scientific article

List of works by Yardena Samuels

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma

A growing family: adding mutated Erbb4 as a novel cancer target

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

Colorectal cancer: mutations in a signalling pathway

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells.

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma ⬇️

Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells

Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.

Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

Frequent mutations in the MITF pathway in melanoma

Genetic and Functional Analysis of GRIN2A in Tumor Samples.

Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation

High frequency of mutations of the PIK3CA gene in human cancers

IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain

MEK inhibition reverses aberrant signaling in melanoma cells through reorganization of NRas and BRAF in self nano-clusters

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

Molecular Pathways: Dysregulated Glutamatergic Signaling Pathways in Cancer ⬇️

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma

Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma

Mutational inactivation of STAG2 causes aneuploidy in human cancer

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Oncogenic mutations of PIK3CA in human cancers

Parkin Somatic Mutations Link Melanoma and Parkinson's Disease

Parkinson disease (PARK) genes are somatically mutated in cutaneous melanoma

RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

Recurrent inactivating RASA2 mutations in melanoma

Refinement of the Endogenous Epitope Tagging (EET) Technology Allows the Identification of a Novel NRAS Binding Partner in Melanoma.

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms

Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA

Shimmer: detection of genetic alterations in tumors using next-generation sequence data

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin

Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications.

TYRO3-mediated regulation of MITF: a novel target in melanoma?

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

The functional relevance of somatic synonymous mutations in melanoma and other cancers

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens.

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.