List of works - Gary G. Chiang

Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

scientific article published on 13 October 2011

Control of mTORC1 signaling by the Opitz syndrome protein MID1.

scientific article published on 9 May 2011

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase

scientific article published on 29 May 2020

Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway

scientific article published on 9 November 2010

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

scientific article published on 3 May 2017

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

scientific article

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

scientific article published on 29 April 2015

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

scientific article published on 27 September 2017

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways

scientific article

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

scientific article published on September 2005

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

scientific article

Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis

scientific article

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

scientific article

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

scientific article

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

scientific article

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

scientific article

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding

scientific article published on 20 February 2017

Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase

scientific article (publication date: 22 June 2001)

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

scientific article published on 10 March 2018

Targeting oncogene mRNA translation in B cell malignancies with eFT226, a potent and selective inhibitor of eIF4A1

scientific article published on 09 October 2020

Targeting the mTOR signaling network in cancer.

scientific article published on October 2007

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

scientific article published on 30 January 2017

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

scientific article published on 6 July 2015

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

scientific article published on 23 January 2017

The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.

scientific article

Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice ⬇️

scientific article published on October 12, 2010

Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product.

scientific article published on July 1997

List of works by Gary G. Chiang

Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

Control of mTORC1 signaling by the Opitz syndrome protein MID1.

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase

Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding

Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

Targeting oncogene mRNA translation in B cell malignancies with eFT226, a potent and selective inhibitor of eIF4A1

Targeting the mTOR signaling network in cancer.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control.

Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice ⬇️

Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product.