List of works - Timothy A. Graubert

A call to action for acute lymphoblastic leukemia.

scientific article published in September 2014

A high resolution map of segmental DNA copy number variation in the mouse genome

scholarly article by Timothy Graubert published in January 2005

A high-resolution map of segmental DNA copy number variation in the mouse genome

scientific article (publication date: 5 January 2007)

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.

scientific article published in October 2003

A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid leukemia

scientific article published on 20 December 2019

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

scientific article

A randomized double-blind trial of hydroxychloroquine for the prevention of chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation.

scientific article published on October 2007

AML Genomics for the Clinician

article

AML Genomics: Introduction

scientific article published on 28 August 2014

AML1 and Evi1: coconspirators in MDS/AML?

scientific article published on 01 April 2008

Acquired copy number alterations in adult acute myeloid leukemia genomes

scholarly article

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial

scientific article published on 11 December 2019

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

scientific article

Case 37-2016. An 86-Year-Old Woman with Leukocytosis and Splenomegaly

scientific article published in December 2016

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice

scientific article

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

scientific article published on 31 January 2018

Clonal Hematopoiesis and Measurable Residual Disease Assessment in Acute Myeloid Leukemia

scientific article published on 13 March 2020

Clonal architecture of secondary acute myeloid leukemia

scientific article published on 14 March 2012

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing

scientific article

Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.

scientific article published on 27 February 2013

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing ⬇️

scientific article (publication date: 11 January 2012)

Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia

scientific article

Corrigendum to “Sca-1 negatively regulates proliferation and differentiation of muscle cells” [Dev. Biol. 283 (2005) 240–252]

scholarly article published in Developmental Biology

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

scientific article

DNMT3A Mutations in Acute Myeloid Leukemia

scientific article (publication date: 16 December 2010)

Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

scientific article

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

scientific article

Dominant Negative Effects of the AML1/ETO Fusion Oncoprotein

article

Enhanced green fluorescent protein targeted to the Sca-1 (Ly-6A) locus in transgenic mice results in efficient marking of hematopoietic stem cells in vivo

scientific article published on 01 February 2003

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

scientific article

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia

scientific article published on 06 March 2014

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

scientific article

Genetics of Myelodysplastic Syndromes: New Insights ⬇️

scientific article published on January 1, 2011

Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility

scientific article published on 18 March 2009

Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia

scientific article

Genomics in childhood acute myeloid leukemia comes of age.

scientific article published in January 2018

Genomics of acute myeloid leukemia

scientific article

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

scientific article

Health care utilization and end-of-life care for older patients with acute myeloid leukemia

scientific article published on 29 April 2015

HighNPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

article

How do cytotoxic lymphocytes kill their targets?

scientific article published on 01 October 1998

Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.

scientific article

Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice

scientific article

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

scientific article published on 26 December 2007

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

scientific article published on 31 October 2018

Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project.

scientific article

Integrated analysis of germline and somatic variants in ovarian cancer.

scientific article

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis

scientific article

Integrated genomics of susceptibility to alkylator-induced leukemia in mice

scientific article

Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia

scientific article published on 13 November 2018

Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity

scientific article published in October 2003

Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy

scientific article published on 16 July 2020

Molecular basis of hematology

Murine models of human acute myeloid leukemia.

scientific article

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

scientific article published on May 2015

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

scientific article published on 09 January 2017

Mutation Clearance after Transplantation for Myelodysplastic Syndrome

scientific article published on 01 September 2018

New molecular abnormalities and clonal architecture in AML: from reciprocal translocations to whole-genome sequencing

scientific article published on January 2014

Next-generation sequencing of cancer genomes: back to the future.

scientific article

Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results

scientific article

Patterns and functional implications of rare germline variants across 12 cancer types

scientific article

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation

scientific article published on August 1997

Pharmacogenetics of alkylator-associated acute myeloid leukemia.

scientific article published on July 2006

Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia

scientific article

Prognostic understanding, quality of life and mood in patients undergoing hematopoietic stem cell transplantation.

scientific article published on 11 May 2015

Quality of life and mood of patients and family caregivers during hospitalization for hematopoietic stem cell transplantation

scientific article

Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice

scientific article published on 13 June 2008

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.

scientific article published on 2 December 2015

Recombinant retroviral systems for the analysis of drug resistant HIV.

scientific article published on October 1993

Recruitment of Bone Marrow-Derived Endothelial Cells to Sites of Pancreatic -Cell Injury

article

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

scientific article

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

scientific article published on 11 December 2011

Recurring mutations found by sequencing an acute myeloid leukemia genome

scientific article

Reduced risk of acute GVHD following mobilization of HLA-identical sibling donors with GM-CSF alone

scientific article published on 01 September 2005

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.

scientific article

Roles of Sca-1 in hematopoietic stem/progenitor cell function

scientific article

SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM)

scientific article published on 29 April 2020

SWR/J mice are susceptible to alkylator-induced myeloid leukemia

scientific article published on 15 November 2013

Sca-1 negatively regulates proliferation and differentiation of muscle cells.

scientific article

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population

scientific article published in May 2002

SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution

scientific article (publication date: August 2014)

Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

scientific article

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

scientific article published on 28 February 2019

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

scientific article published on 12 February 2008

Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes

scientific article published on 27 July 2018

Splicing factor gene mutations in hematologic malignancies

scientific article published on 9 December 2016

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

scholarly article

Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene

scientific article published on June 1998

Structural variation of the mouse natural killer gene complex.

scientific article

Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant

scientific article published on 8 March 2018

Supraventricular tachyarrhythmias after hematopoietic stem cell transplantation: incidence, risk factors and outcomes

scientific article published on 01 October 2004

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes

scientific article

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

scientific article published on 11 January 2019

Targeting R-loop-associated ATR response in myelodysplastic syndrome

The Origin and Evolution of Mutations in Acute Myeloid Leukemia ⬇️

scientific article (publication date: 20 July 2012)

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on 11 July 2016

The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells

scientific article published on 08 March 2009

Therapy related acute myeloid leukemia in breast cancer survivors, a population-based study.

scientific article

Therapy-related myelodysplastic syndrome: models and genetics

scientific article published on 24 October 2009

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing

scientific article

Use of whole-genome sequencing to diagnose a cryptic fusion oncogene

scientific article

wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data

scientific article

List of works by Timothy A. Graubert

A call to action for acute lymphoblastic leukemia.

A high resolution map of segmental DNA copy number variation in the mouse genome

A high-resolution map of segmental DNA copy number variation in the mouse genome

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.

A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid leukemia

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes.

A randomized double-blind trial of hydroxychloroquine for the prevention of chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation.

AML Genomics for the Clinician

AML Genomics: Introduction

AML1 and Evi1: coconspirators in MDS/AML?

Acquired copy number alterations in adult acute myeloid leukemia genomes

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

Case 37-2016. An 86-Year-Old Woman with Leukocytosis and Splenomegaly

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Clonal Hematopoiesis and Measurable Residual Disease Assessment in Acute Myeloid Leukemia

Clonal architecture of secondary acute myeloid leukemia

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing

Clonal diversity of recurrently mutated genes in myelodysplastic syndromes.

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing ⬇️

Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia

Corrigendum to “Sca-1 negatively regulates proliferation and differentiation of muscle cells” [Dev. Biol. 283 (2005) 240–252]

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

DNMT3A Mutations in Acute Myeloid Leukemia

Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia

Dominant Negative Effects of the AML1/ETO Fusion Oncoprotein

Enhanced green fluorescent protein targeted to the Sca-1 (Ly-6A) locus in transgenic mice results in efficient marking of hematopoietic stem cells in vivo

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

Genetics of Myelodysplastic Syndromes: New Insights ⬇️

Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility

Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia

Genomics in childhood acute myeloid leukemia comes of age.

Genomics of acute myeloid leukemia

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

Health care utilization and end-of-life care for older patients with acute myeloid leukemia

HighNPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

How do cytotoxic lymphocytes kill their targets?

Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.

Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project.

Integrated analysis of germline and somatic variants in ovarian cancer.

Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis

Integrated genomics of susceptibility to alkylator-induced leukemia in mice

Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia

Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity

Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy

Molecular basis of hematology

Murine models of human acute myeloid leukemia.

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome

Mutation Clearance after Transplantation for Myelodysplastic Syndrome

New molecular abnormalities and clonal architecture in AML: from reciprocal translocations to whole-genome sequencing

Next-generation sequencing of cancer genomes: back to the future.

Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results

Patterns and functional implications of rare germline variants across 12 cancer types

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation

Pharmacogenetics of alkylator-associated acute myeloid leukemia.

Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia

Prognostic understanding, quality of life and mood in patients undergoing hematopoietic stem cell transplantation.

Quality of life and mood of patients and family caregivers during hospitalization for hematopoietic stem cell transplantation

Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.

Recombinant retroviral systems for the analysis of drug resistant HIV.

Recruitment of Bone Marrow-Derived Endothelial Cells to Sites of Pancreatic -Cell Injury

Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

Recurring mutations found by sequencing an acute myeloid leukemia genome

Reduced risk of acute GVHD following mobilization of HLA-identical sibling donors with GM-CSF alone

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.

Roles of Sca-1 in hematopoietic stem/progenitor cell function

SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM)

SWR/J mice are susceptible to alkylator-induced myeloid leukemia

Sca-1 negatively regulates proliferation and differentiation of muscle cells.