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List of works by Mikhail Krasavin

A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis

scientific article published on 15 April 2019

A simple, three-component synthesis of 2-aminothiazoles using trimethylsilyl isothiocyanate

article published in 2013

A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles.

scientific article published on 7 May 2019

An improved kilogram-scale preparation of atorvastatin calcium

scientific article published on 13 February 2015

Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.

scientific article

Antimalarial sulfide, sulfone, and sulfonamide trioxanes

scientific article published on 01 June 2000

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

scientific article published on October 1999

Antiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype.

scientific article

Attachment of a 5-nitrofuroyl moiety to spirocyclic piperidines produces non-toxic nitrofurans that are efficacious in vitro against multidrug-resistant Mycobacterium tuberculosis

scientific article published on 23 January 2019

Bicyclic Piperazine Mimetics of the Peptide β-Turn Assembled via the Castagnoli-Cushman Reaction

scientific article published on 03 May 2018

Biologically active compounds based on the privileged 2-imidazoline scaffold: The world beyond adrenergic/imidazoline receptor modulators.

scientific article

Complexity-Enhancing Acid-Promoted Rearrangement of Tricyclic Products of Tandem Ugi 4CC/Intramolecular Diels−Alder Reaction

scientific article published on 01 December 2006

Conjugation of a 5-nitrofuran-2-oyl moiety to aminoalkylimidazoles produces non-toxic nitrofurans that are efficacious in vitro and in vivo against multidrug-resistant Mycobacterium tuberculosis

scientific article published on 29 August 2018

Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists.

scientific article

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment

scientific article published on 21 December 2018

Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli-Cushman Reaction of Unprotected Oximes

scientific article published on 26 October 2017

Dihydro-resveratrol--a potent dietary polyphenol.

scientific article published on 5 August 2010

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications.

scientific article

Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer

scientific article

Efficient entry into hydrazinopeptide-like structures via sequential Ugi reactions

scientific article published on 10 November 2009

Exploration of the nitrogen heterocyclic periphery around the core of the advanced FFA1 agonist fasiglifam (TAK-875)

scientific article published on 03 December 2020

From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction

scientific article published on 26 August 2019

Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

scientific article published on 01 December 2020

Identification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: the special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazole

scientific article

Imidazo[1,2-a]quinoxalines accessed via two sequential isocyanide-based multicomponent reactions

scientific article published on 01 March 2009

Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.

scientific article published on 15 September 2017

Mixed carboxylic-sulfonic anhydride in reaction with imines: a straightforward route to water-soluble β-lactams via a Staudinger-type reaction

scientific article published on 01 May 2018

Multi-component reactions between 2-aminopyrimidine, aldehydes and isonitriles: the use of a nonpolar solvent suppresses formation of multiple products

Mutually Isomeric 2- and 4-(3-nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens

scientific article published on 01 October 2020

Natural products as templates for bioactive compound libraries: part 2. Novel modifications of vasicine (peganine) core via efficient and regioselective generation of 3-lithiodeoxyvasicine and its stereoselective addition to aliphatic ketones sectio

scientific article

Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (+/-)-vasicine

scientific article

Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity

scientific article published on 29 October 2018

One-Pot Conversion of Aldehydes and Aryl Halides to Disubstituted Alkynes via Tandem Seyferth-Gilbert Homologation/Copper-Free Sonogashira Coupling

scientific article published on 21 June 2019

One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines

scientific article published on 01 March 2006

One-step construction of peptidomimetic 5-carbamoyl-4-sulfonyl-2-piperazinones

scientific article published on 01 May 2005

Panel docking of small-molecule libraries - Prospects to improve efficiency of lead compound discovery

scientific article published on 27 May 2015

Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835.

scientific article published on 4 January 2017

Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.

scientific article published on 8 July 2014

Preparation and in situ use of unstable N-alkyl α-diazo-γ-butyrolactams in RhII-catalyzed X-H insertion reactions

scientific article published on 02 April 2020

Primary mono- and bis-sulfonamides obtained via regiospecific sulfochlorination of N-arylpyrazoles: inhibition profile against a panel of human carbonic anhydrases.

scientific article

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines

scientific article published on 15 February 2019

Rare Medium-Sized Rings Prepared via Hydrolytic Imidazoline Ring Expansion (HIRE)

scientific article published on 22 August 2018

Rethinking Hydrolytic Imidazoline Ring Expansion: A Common Approach to the Preparation of Medium-Sized Rings via Side-Chain Insertion into [1.4]Oxa- and [1.4]Thiazepinone Scaffolds

scientific article published on 24 December 2018

Rh(II)-Catalyzed Spirocyclization of α-Diazo Homophthalimides with Cyclic Ethers

scientific article published on 12 March 2019

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

scientific article published on 01 December 2020

Skeletal Diversity in Combinatorial Fashion: A New Format for the Castagnoli-Cushman Reaction.

scientific article

Spirocyclizations Involving Oxonium Ylides Derived from Cyclic α-Diazocarbonyl Compounds: An Entry into 6-Oxa-2-azaspiro[4.5]decane Scaffold

scientific article published on 23 November 2020

Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion.

scientific article

The Chan-Evans-Lam N-Arylation of 2-Imidazolines.

scientific article

Three-Component Castagnoli-Cushman Reaction of 3-Arylglutaconic Acids with Aromatic Aldehydes and Amines Delivers Rare 4,6-Diaryl-1,6-dihydropyridin-2(3 H)-ones

scientific article published on 22 February 2019

Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors.

scientific article published on 21 November 2017

Unusually Reactive Cyclic Anhydride Expands the Scope of the Castagnoli-Cushman Reaction

scientific article published on 28 September 2018

α-Acyl-α-diazoacetates in Transition-Metal-Free β-Lactam Synthesis

scientific article published on 03 September 2019

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