List of works - Piet Herdewijn

(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity

scientific article published in April 2001

1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro

article

1,2;3,4-Di-O-isopropylidene-l-galactose synthesis from its d-enantiomer

1,5-Anhydro-2-Deoxy-D-Altritol Oligonucleotides as Conformationally Restricted Analogues of Rna

1-(2,3-Dideoxy-erythro-beta-D-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach

scientific article published on February 1, 1992

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase

scientific article

1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

1′,5′-Anhydro-l-ribo-hexitol Adenine Nucleic Acids (α-l-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World

scientific article published on 30 April 2015

1′,5′-Anhydrohexitol Oligonucleotides: Hybridisation and Strand Displacement with Oligoribonucleotides, Interaction with RNase H and HIV Reverse Transcriptase

article

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

scientific article

2'-Deoxyribonucleoside phosphoramidate triphosphate analogues as alternative substrates for E. coli polymerase III.

scientific article published on 28 September 2012

2'-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides

scientific article published on January 2007

2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

scientific article published in August 2003

3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.

scientific article

3′-Amidated 3′-Deoxyxylofuranose Analogues of N 6-−Cyclopentyladenosines: a New Class of Non-Xanthine Antagonists at the Adenosine A1 Receptor

3′-Deoxy-3′-hydroxymethyl-aldopentopyranosyl nucleoside synthesis. Part I

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

scientific article published in April 2002

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity

scientific article

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

scientific article (publication date: August 1991)

5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

5-Hydroxytryptophan as a building block in oligopeptides using Fmoc/tBu SPPS

5-Substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase

scientific article published on 01 June 1999

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo

scientific article

A Methyl Group Controls Conformational Equilibrium in Human Mitochondrial tRNALys

scientific article published on 17 October 2007

A Novel and Enantioselective Approach to the Synthesis of Cyclohexane Carbocyclic Nucleosides Starting from (-)-Carvone

A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics ⬇️

scientific article

A Potential Prebiotic Route to Adenine from Hypoxanthine

scholarly article by Irene M. Lagoja published in July 2005

A Single Amino Acid Substitution in Therminator DNA Polymerase Increases Incorporation Efficiency of Deoxyxylonucleotides

scientific article published on 26 October 2018

A Straightforward Stereoselective Synthesis of d- and l-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanine ⬇️

scientific article published on December 14, 2001

A Versatile NMR Technique for the Identification of Phosphorylation Sites in Oligosaccharides

A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro

scientific article

A highly enantio-selective hexitol nucleic acid template for nonenzymatic oligoguanylate synthesis.

scientific article

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

scientific article published on 12 March 2009

A novel and convenient strategy for the synthesis of phthalazines from an aryne precursor

A novel helper phage for HaloTag-mediated co-display of enzyme and substrate on phage

scientific article

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

scientific article

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

scientific article

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

scientific article

A short and convenient strategy for the synthesis of pyridazines via Diaza–Wittig reaction

A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides

scientific article published in March 2003

A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis

scientific article

A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates

scientific article

Access to a New Type of Homo-C-Nucleosides with a “Split” 8-Deazapurine via a 1,3-Dipolar Cycloaddition Reaction

Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer

Acyclic oligonucleotides: possibilities and limitations

Additions and Corrections - Resolution of Aristeromycin Enantiomers

article

Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA.

scientific article

Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.

scientific article published on 19 October 2011

Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.

scientific article published in December 2001

Amidate Prodrugs of Cyclic 9-()-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication

scientific article published on 17 October 2016

Amino Acid Phosphoramidate Nucleotides as Alternative Substrates for HIV-1 Reverse Transcriptase

article

Amino acids derived from ornithine

Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants

scientific article published on 26 April 2008

An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside

scientific article

An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors

scientific article

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

scientific article published on 18 October 2009

Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

article

Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides

scientific article published on 07 March 2020

Antibacterial 5'-O-(N-dipeptidyl)-sulfamoyladenosines.

scientific article

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

scientific article published on 27 February 2017

Antimalarial antisense activity of hexitol nucleic acids

scientific article published on 01 October 1999

Antisense oligonucleotides

scientific article published on 01 January 1996

Application of the Mitsunobu-Type Condensation Reaction to the Synthesis of Phosphonate Derivatives of Cyclohexenyl and Cyclohexanyl Nucleosides

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication

scientific article published on May 2015

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.

scientific article published on 7 October 2017

Base pairing involving artificial bases in vitro and in vivo.

scientific article

Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA).

scientific article published in January 2003

Base-Modified Nucleic Acids as a Powerful Tool for Synthetic Biology and Biotechnology

scientific article

Base−Base Interactions in the Minor Groove of Double-Stranded DNA

Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity

scientific article published on September 2016

Binary genetic cassettes for selecting XNA-templated DNA synthesis in vivo

scientific article published on 26 June 2013

Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA

scientific article published on 01 March 2000

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf

scientific article published on 30 January 2009

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

scientific article

Branched-chain nucleosides: Synthesis of 3′-deoxy-3′-C- hydroxymethyl-α-l-lyxopyranosyl thymine and 3′-deoxy- 3′-C-hydroxymethyl-α-l-threofuranosyl thymine

Carbohydrate chiral-pool approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates

article published in 2008

Carbohydrate-based approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates

Catalysts from synthetic genetic polymers

scientific article

Characterization and sequence confirmation of unnatural amino acid containing peptide libraries using electrospray ionization mass spectrometry

scientific article

Characterization of modification sites during peptide synthesis using liquid secondary ion/collision-induced dissociation mass spectrometry and a computer program

scholarly article by Jef Rozenski et al published November 1994 in Journal of Mass Spectrometry

Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties

scientific article

Characterization of the posttranscriptional modifications in Legionella pneumophila small-subunit ribosomal RNA.

scientific article published in December 2008

ChemInform Abstract: Oligonucleotides Containing Disaccharide Nucleosides

ChemInform Abstract: Selection of New Sequence-Selective Unnatural Peptides Binding to Double-Stranded Deoxyribonucleic Acids (dsDNA) by Means of a Gel-Retardation Experiment for Library Analysis

Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs)

scientific article published on 01 April 2007

Chemical Morphing of DNA Containing Four Noncanonical Bases

article published in 2016

Chemical Morphing of DNA Containing Four Noncanonical Bases.

scientific article

Chemical Synthesis of 13C and 15N Labeled Nucleosides

Chemical evolution of a bacterium's genome.

scientific article

Chemical fidelity of an RNA polymerase ribozyme

article by James Attwater et al published 2013 in Chemical Science

Chemical incorporation of 1-methyladenosine into oligonucleotides

scientific article published on March 2002

Chemical incorporation of 1-methyladenosine, minor tRNA component, into oligonucleotides.

scientific article published in May 2003

Chemical incorporation of minor tRNA component O-β-D-ribofuranosyl-(1''-2')-adenosine-5''-phosphate into oligoribonucleotides

Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside

scientific article

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

scientific article (publication date: September 2008)

Comparative Liquid Chromatographic Stability Study of Thymidine and 1- (2-Deoxy-α-D-Erythro-Pentofuranosyl) Thymine

Comparative structural dynamics of Tyrosyl-tRNA synthetase complexed with different substrates explored by molecular dynamics

scientific article published on 17 June 2008

Comparison between the orthorhombic and tetragonal forms of the heptamer sequence d[GCG(xT)GCG]/d(CGCACGC) ⬇️

scientific article published on August 26, 2010

Comparison of library screening techniques used in the development of dsDNA ligands

scientific article

Complete NMR characterization of lychnose from Stellaria media (L.) Vill

article by Mieke Vanhaecke et al published November 2006 in Carbohydrate Research

Complexation of lipofectamine and cholesterol-modified DNA sequences studied by single-molecule fluorescence techniques

scientific article published on 25 October 2007

Computational alanine scanning and free energy decomposition for E. coli type I signal peptidase with lipopeptide inhibitor complex

scientific article published on 3 May 2007

Conformational and Chiral Selection of Oligonucleotides

scientific article published on 01 April 2007

Conformationally restricted carbohydrate-modified nucleic acids and antisense technology

scientific article

Conjugation of Oligonucleotides to 3′-Polar Moieties

article

Contribution of dihydrouridine in folding of the D-arm in tRNA

scientific article

Cooperative dynamics of a DNA polymerase replicating complex

scientific article published on 13 September 2013

Correct bond order assignment in a molecular framework using integer linear programming with application to molecules where only non-hydrogen atom coordinates are available

scientific article published in September 2005

Correction: Base pairing involving artificial bases and

Corrigendum to “Substrate based peptide aldehyde inhibits bacterial type I signal peptidase” [Bioorg. Med. Chem. Lett. 19 (2009) 2880]

scholarly article published in Bioorganic & Medicinal Chemistry Letters

Corrigendum to “Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents” [Tetrahedron 54 (1998) 2209]

scholarly article published in Tetrahedron

Cover Picture: Polymerase-Catalysed Incorporation of Glucose Nucleotides into a DNA Duplex (Chem. Eur. J. 22/2009)

Crystal structure of double helical hexitol nucleic acids

scientific article

Crystallization and preliminary X-ray study of the D-altritol oligonucleotide GTGTACAC.

scientific article

Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines

scientific article published on 28 November 2018

Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

scientific article published in 2000

Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity.

scientific article published in April 2001

Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides

scientific article

DNA duplexes with reactive dialdehyde groups as novel reagents for cross-linking to restriction- modification enzymes.

scientific article published on August 1997

DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods

scientific article published on June 2002

De novo approach to l-anhydrohexitol nucleosides as building blocks for the synthesis of l-hexitol nucleic acids (l-HNA)

Delivery of antisense oligonucleotides using cholesterol-modified sense dendrimers and cationic lipids

scientific article published on July 2005

Delta-di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase

scientific article published on 8 August 2009

Dendritic Nucleotides: Interaction with an Aliphatic Acid Monolayer

scientific article published on 01 September 2008

Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents

scientific article published in April 2005

Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization

scientific article published on 9 December 2014

Design of Bioactive Peptides from Naturally Occurring -Conotoxin Structures

scientific article

Detection of RNA hybridization by pyrene-labeled probes.

scientific article published in May 2009

Development of Synthetic Strategies for the Construction of Pyrido[4,3-d]pyrimidine Libraries – the Discovery of a New Class of PDE-4 Inhibitors

article

Development of Synthetic Strategies for the Construction of Pyrido[4,3-d]pyrimidine Libraries — The Discovery of a New Class of PDE-4 Inhibitors

Diagnostic accuracy of a new Leishmania PCR for clinical visceral leishmaniasis in Nepal and its role in diagnosis of disease

scientific article

Difference in conformational diversity between nucleic acids with a six-membered 'sugar' unit and natural 'furanose' nucleic acids

scientific article

Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

article

Dipeptides as leaving group in the enzyme-catalyzed DNA synthesis

scientific article published in December 2012

Direct observation of two cyclohexenyl (CeNA) ring conformations in duplex DNA ⬇️

scientific article published on July 1, 2010

Disaccharide Nucleosides And Their Enzymatic And Chemical Incorporation Into Oligonucleotides

article

Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity

Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo

scientific article published on 19 July 2018

Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile

scientific article published on 27 March 2017

Discovery of a new subclass of α-conotoxins in the venom of Conus australis

scientific article

Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium Tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue

scholarly article published 2014

Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue

scientific article

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

scientific article published in December 2004

Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach

scientific article

Divers Stereoisomers of N-Acetylhydroxyprolinol as Sugar Substitute in Oligonucleotides

article by G. Ceulemans et al published September 1998 in Nucleosides & nucleotides

Double Protection of the Heterocyclic Base of Xanthosine and 2′-Deoxyxanthosine

Easy Synthesis and Different Conformational Behavior of Purine and Pyrimidine .beta.-D-glycero-Pent-2'-enopyranosyl Nucleosides

article by Bogdan Doboszewski et al published December 1995 in Journal of Organic Chemistry

Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.

scientific article published on March 1986

Effect of Molecular Crowding on DNA Polymerase Reactions along Unnatural DNA Templates

scientific article published on 10 September 2020

Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons

scientific article

Effects of Six-Membered Carbohydrate Rings on Structure, Stability, and Kinetics of G-Quadruplexes

Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization.

scientific article published in January 1999

Emimycin and its nucleoside derivatives: Synthesis and antiviral activity

scientific article published on 7 December 2017

Enantiomeric Selection Properties of β-homoDNA: Enhanced Pairing for Heterochiral Complexes

scientific article published on 13 May 2013

Enantioselective Approach to the Synthesis of Cyclohexane Carbocyclic Nucleosides

Enantioselective Synthesis and Conformational Analysis of Cyclohexene Carbocyclic Nucleosides

Enantioselective Synthesis and Conformational Study of Cyclohexene Carbocyclic Nucleosides

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

scientific article published on 22 October 2020

Enzymatic Incorporation in DNA of 1,5-Anhydrohexitol Nucleotides†

scientific article published on 01 October 2000

Enzymatic Incorporation of Modified Purine Nucleotides in DNA.

scientific article

Enzymatic Synthesis of Phosphonomethyl Oligonucleotides by Therminator Polymerase

scholarly article by Marleen Renders et al published 26 March 2007 in Angewandte Chemie International Edition

Enzymatic Synthesis of Phosphonomethyl Oligonucleotides by Therminator Polymerase

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

scientific article

Enzymatic polymerization of phosphonate nucleosides.

scientific article

Enzymatic resolution and base pairing properties of D- and L-cyclohexenyl nucleic acids (CeNA).

scientific article

Enzymatically catalyzed DNA synthesis using L-Asp-dGMP, L-Asp-dCMP, and L-Asp-dTMP.

scientific article

Evaluation of Capillary HPLC/Mass Spectrometry as an Alternative Analysis Method for Gel Electrophoresis of Oligonucleotides

article published in 2004

Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and d-altritol nucleic acid-modified 2'-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro

scientific article published on 28 October 2016

Evaluation of the Kinetics of Hydrolysis of Diamino Analogues of 2′- Or 3′-Deoxyadenosine and of 9-(2-Deoxy-β-D-threo−Pentofuranosyl)adenine or 9-(3-Dexoy-β-D-threo−Pentofuranosyl)adenine By Liquid Chromatography

Evaluation of the Kinetics of Hydrolysis of Monoamino Analogues of 2′- or 3′-Deoxyadenosine and of 9-(2-Deoxy-β-D-Threo-pentofuranosyl)Adenine or 9-(3-Deoxy-β-D-threo-pentofuranosyl)Adenine by Liquid Chromatography

Evaluation of the cellular uptake of hexitol nucleic acids in HeLa cells

scientific article published on 01 August 2000

Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis

scientific article published on 20 August 2009

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs

scientific article published on 6 July 2017

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

scientific article

Facile Synthesis of 3′-C-Branched 1,5-Anhydrohexitol Nucleosides

Facile immobilization of DNA using an enzymatic his-tag mimic.

scientific article published on 22 November 2017

Formation of a 2-methyl-branched fatty aldehyde during peroxisomal α-oxidation

scientific article published on 01 August 1997

Full Pre-Steady-State Kinetic Analysis of Single Nucleotide Incorporation by DNA Polymerases

scientific article published on 01 September 2019

Further biological and molecular characterization of actinophage VWB.

scientific article

Gas chromatographic determination of alkyl lysophospholipids after solid-phase extraction from cell culture media

article

Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain

scientific article

Glycosyl Transferase Activity of theEscherichia coliPenicillin-Binding Protein 1b: Specificity Profile for the Substrate†

scientific article published in 2006

HNA and ANA high-affinity arrays for detections of DNA and RNA single-base mismatches

scientific article published on 13 February 2008

Helical structure of xylose-DNA.

scientific article published in January 2010

Heterocyclic modifications of oligonucleotides and antisense technology.

scientific article

Hexitol Nucleic Acids (HNA): Synthesis and Properties

article

Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA.

scientific article published in March 2005

Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives

scientific article published on 24 September 2010

Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity

scientific article published in 1996

How does hydroxyl introduction influence the double helical structure: the stabilization of an altritol nucleic acid:ribonucleic acid duplex

scientific article

Hybridization between “Six-Membered” Nucleic Acids: RNA as a Universal Information System

scientific article published on 01 December 2001

Hybridization specificity, enzymatic activity and biological (Ha-ras) activity of oligonucleotides containing 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosides

scientific article published in October 1993

Hydrolysis of aspartic acid phosphoramidate nucleotides: a comparative quantum chemical study

scientific article published on 11 June 2009

Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents

scientific article published on 29 December 2013

IDENTIFICATION OF THE EXOPOLYSACCHARIDE AMYLOVORAN BY NMR[1]

Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase

scientific article

Identification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach.

scientific article published on March 1995

Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.

scientific article published on 22 October 2007

Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).

scientific article

Iminodiacetic-phosphoramidates as metabolic prototypes for diversifying nucleic acid polymerization in vivo

scientific article published on 22 January 2010

Iminodipropionic acid as the leaving group for DNA polymerization by HIV-1 reverse transcriptase.

scientific article

Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congeners

scientific article published on October 2001

In Search of Acyclic Analogues as Universal Nucleosides in Degenerate Probes

In vitro NCp7 enhancement of ribozyme-mediated cleavage of full-length human IL-6 mRNA.

scientific article published in September 1995

In vitro disposition profiling of heterocyclic compounds

scientific article published on June 2015

Incorporation of 5-hydroxytryptophan in oligopeptides

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.

scientific article published on 29 February 2016

Incorporation of a disaccharide nucleoside into the backbone of double-stranded DNA: crystallization and preliminary X-ray diffraction

scientific article published on 30 September 2005

Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability ⬇️

scientific article published on September 25, 1992

Increased uptake of antisense oligonucleotides by delivery as double stranded complexes

scientific article published on August 2004

Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2',3'-Dideoxynucleosides

article

Influence of Threose Nucleoside Units on the Catalytic Activity of a Hammerhead Ribozyme

scholarly article by Veerle Kempeneers published in January 2004

Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(CGCGAATTCGCG)

scientific article

Influence of the linkage between leaving group and nucleoside on substrate efficiency for incorporation in DNA catalyzed by reverse transcriptase

scientific article published in July 2010

Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates

scientific article published on 15 December 2011

Inhibition of MDR1 expression with altritol-modified siRNAs

scientific article published on 30 January 2007

Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides

scientific article

Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs.

scientific article

Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives

scientific article published on 24 April 2007

Insight into ligand selectivity in HCV NS5B polymerase: molecular dynamics simulations, free energy decomposition and docking

scientific article

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound

scientific article

Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA)

scientific article published on 28 June 2019

Investigation of The Kinetics of Degradation of Hexopyranosylated Cytosine Nucleosides Using Liquid Chromatography

Investigation of the DNA-dependent cyclohexenyl nucleic acid polymerization and the cyclohexenyl nucleic acid-dependent DNA polymerization

scientific article

Investigations on Sarcosine and Isonipecotic Acid Containing Peptide Nucleic Acids

Iron/Copper Co-Catalyzed Cross-Coupling Reaction for the Synthesis of 6-Substituted 7-Deazapurines and the Corresponding Nucleosides

scientific article published on 20 December 2019

Isoguanine and 5-methyl-isocytosine bases, in vitro and in vivo

scientific article published on 13 February 2015

Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster

scientific article

Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase : synthesis, structure-activity relationship studies and antiviral activity.

scientific article published on 07 August 2015

L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation

scientific article published on 22 March 2016

Lead Optimization ofN6-Cyclopentyl-3′-amido-3′-deoxyxylofuranosyladenines as Adenosine A1Receptor Antagonists

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

scientific article

Liquid chromatographic separation of hexopyranosylated cytosine nucleosides from their degradation products

scientific article published on 01 November 1997

Liquid chromatographic study of the stability of 5-halogeno-2′-deoxyuridines

scientific article published on 01 April 1993

Mapping of T7 RNA polymerase active site with novel reagents - oligonucleotides with reactive dialdehyde groups

article

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

scientific article

Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.

scientific article published on March 1994

Metabolic Recruitment and Directed Evolution of Nucleoside Triphosphate Uptake in Escherichia coli.

scientific article

Methylated Hexitol Nucleic Acids, Towards Congeners with Improved Antisense Potential

scientific article published on 01 May 2003

Methylated Nucleobases: Synthesis and Evaluation for Base Pairing In Vitro and In Vivo

scientific article published on 23 July 2018

Mixed oligonucleotide analogues with an acyclic carbohydrate moiety and a N-cyanoguanidine functionality

scientific article published in 1994

Modified oligonucleotides containing 1-beta-D-galactopyranosylthymine: synthesis and substrate properties

scientific article published in January 2002

Modulation of BACE1 Activity by Chemically Modified Aptamers

scientific article published on 11 January 2018

Molecular Dynamics of double stranded Xylo Nucleic Acid (XyloNA).

scientific article

Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection

scientific article

Molecular dipstick test for diagnosis of sleeping sickness.

scientific article published on August 2006

Molecular simulation of cyclohexanyl nucleic acid (CNA) duplexes with CNA, DNA and RNA and CNA triloop and tetraloop hairpin structures

scientific article published on 3 March 2016

Molecular-Dynamics Studies of Single-Stranded Hexitol, Altritol, Mannitol, and Ribose Nucleic Acids (HNA, MNA, ANA, and RNA, Resp.) and of the Stability of HNA⋅RNA, ANA⋅RNA, and MNA⋅RNA Duplexes

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Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

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Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors: Biological Evaluation and Conformational Analysis of 2′- and 3′-Modified Thymidine Analogues

scholarly article by Philippe Van Rompaey et al published August 2003 in European Journal of Organic Chemistry

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

scientific article published on April 2003

N8-Glycosylated 8-Azapurine and Methylated Purine Nucleobases: Synthesis and Study of Base Pairing Properties

scientific article published on 16 October 2019

NMR study on the interaction of the conserved CREX 'stem-loop' in the Hepatitis E virus genome with a naphthyridine-based ligand

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NMR-based conformational analysis of 2',6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs

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Nanostructures from Synthetic Genetic Polymers

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Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates

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New dsDNA binding unnatural oligopeptides with pyrimidine selectivity

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New dsDNA-Binding Hybrid Molecules Combining an Unnatural Peptide and an Intercalating Moiety

scholarly article by Patrick Chaltin et al published March 2003 in Helvetica Chimica Acta

Nonenzymatic Template-Directed Reactions on Altritol Oligomers, Preorganized Analogues of Oligonucleotides

Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure

scientific article published in March 1999

Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides

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Novel nucleoside strategies for anti-HIV and anti-HSV therapy

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Nucleic acids with a six-membered carbohydrate mimic and RNA interference

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Nucleolipids as potential organogelators

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Nucleosides with Transposed Base or 4'-Hydroxymethyl Moieties and Their Corresponding Oligonucleotides

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Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors ⬇️

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Nucleotides. Part XXXIVSynthesis of Modified Oligomeric 2?-5?A Analogues: Potential Antiviral Agents

scholarly article by Piet Herdewijn et al published 30 January 1991 in Helvetica Chimica Acta

Nucleotides. Part. XXXII. Synthesis of 2?-5? Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides

scholarly article by Piet Herdewijn et al published 13 December 1989 in Helvetica Chimica Acta

Oligodeoxynucleotides Containing 2′-Deoxy-1-methyladenosine andDimroth Rearrangement

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Oligodeoxynucleotides containing N1-methyl-2'-deoxyadenosine and N6-methyl-2'-deoxyadenosine

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Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

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Oligonucleotides Composed of 2‘-Deoxy-1‘,5‘-anhydro-d-mannitol Nucleosides with a Purine Base Moiety

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Oligonucleotides Containing Disaccharide Nucleosides

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Oligonucleotides Containing Disaccharide Nucleosides: Synthesis, Physicochemical, and Substrate Properties

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Oligonucleotides containing a ribo-configured cyclohexanyl nucleoside: probing the role of sugar conformation in base pairing selectivity

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Oligonucleotides with 3-hydroxy-N-acetylprolinol as sugar substitute

article by Griet Ceulemans et al published November 1997 in Tetrahedron

Oligonucleotides with Reactive Dialdehyde Groups as Novel Affinity Reagents

Oligonucleotides with cyclohexene-nucleoside building blocks: crystallization and preliminary X-ray studies of a left-handed sequence GTGTACAC.

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One-Step Synthesis of Hypoxanthine from Glycinamide and Diformylurea

scholarly article by Irene M. Lagoja published in January 2004

Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity

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Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity

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Peptide Analogues of DNA Consisting of l-α-Amino-γ-thymine Butyric Acid and l-Valine Subunits

Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase

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Phenolic profiling of caffeic acid O-methyltransferase-deficient poplar reveals novel benzodioxane oligolignols

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Phospho-carboxylic anhydride of a homologated nucleoside leads to primer degradation in the presence of a polymerase

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Phosphodiester substrates for incorporation of nucleotides in DNA using HIV-1 reverse transcriptase.

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Phosphonates Derivatives of 2',3'-Dideoxy-2',3'-didehydro-pentopyranosyl Nucleosides

Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers.

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Phosphorus Pentachloride Promoted gem-Dichlorination of 2′- and 3′-Deoxynucleosides

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Poly(2-acrylamido-2-methyl-1-propanamide) (PAMPA): A Neutral, Water-Soluble Synthetic Polymer with Double-Stranded Helix Conformation

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Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids

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Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo

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Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing

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Probing ambiguous base-pairs by genetic transformation with XNA templates.

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Probing the MVAI methyltransferase region that interacts with DNA: affinity labeling with the dialdehyde-containing DNA duplexes.

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Properties of Oligonucleotides with Six Membered Carbohydrate Mimics and a 1,4-Relationship Between the Base Moiety and the Hydroxymethyl Group

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Protection of 1-methyladenosine and its chemical incorporation into oligonucleotides

Protection of 2,6-Diaminopurine 2′-Deoxyriboside

Protection of the Lactam Function of 2′-Deoxyinosine with A 2-(4-Nitrophenyl)-Ethyl Moiety

Pseudouridine detection improvement by derivatization with methyl vinyl sulfone and capillary HPLC-mass spectrometry

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RNA as a target for drug design, the example of Tat-TAR interaction.

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RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA).

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Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

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Rational design of a bacterial import system for new-to-nature molecules

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Reaction of adenine nucleosides, tosylated in the carbohydrate moiety, with lithium triethylborohydride

Reactivity of Amino Acid Nucleoside Phosphoramidates: A Mechanistic Quantum Chemical Study

Recognition of HNA and 1,5-anhydrohexitol nucleotides by DNA metabolizing enzymes

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Recognition of threosyl nucleotides by DNA and RNA polymerases

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Redesigning the leaving group in nucleic acid polymerization

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Regioselective 2′-O-debenzoylation of 2',3'-di-O-benzoyl threose nucleosides

Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5,7-dichloropyrido[4,3-d]pyrimidine scaffold

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.

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Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo

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Replicative Capability of Anhydrohexitol Analogues of Nucleotides

Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides

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Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

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Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation

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Ribosylation of Pyrimidine 2′-Deoxynucleosides

SYNTHESIS OFN6-ALKYLATED ADENOSINE DERIVATIVES

Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug

scientific article published on 16 November 2020

Screening of a synthetic pentapeptide library composed of d-amino acids against fructose-1,6-biphosphate aldolase

Selection of New Sequence-Selective Unnatural Peptides Binding to Double-Stranded Deoxyribonucleic Acids (dsDNA) by Means of a Gel-Retardation Experiment for Library Analysis

scholarly article by Patrick Chaltin et al published August 2002 in Helvetica Chimica Acta

Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents

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Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2′-deoxyuridines: Dependence on specific phosphorylation by viral thymidine kinase

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Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

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Self-complementary sequence context in mature miRNAs

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Silica Gel Functionalised with Different Spacers as Solid Support for Oligonucleotide Synthesis

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Simple approach to 1-O-protected (R)- and (S)-glycerols from l- and d-arabinose for glycerol nucleic acids (GNA) monomers research

Simple approach to the synthesis of 3-fluoro pyrazolo[1,5-a]pyrimidine analogues

article by Hassen Bel Abed et al published May 2013 in Tetrahedron Letters

Solid Phase Synthesis of 2′, 5′-Oligoadenylates Containing 3′-Fluorinated Ribose

Solution Structure and Conformational Dynamics of Deoxyxylonucleic Acids (dXNA): An Orthogonal Nucleic Acid Candidate

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Solution Structure of a Hexitol Nucleic Acid Duplex with Four Consecutive T⋅T Base Pairs

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Solution structure of a HNA-RNA hybrid

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Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase

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Some Examples of the Use of Trifluoromethane Sulfonic Anhydride in Nucleic Acid Chemistry

Stereocontrolled Synthesis of Ara-Type Cyclohexenyl Nucleosides

Stereocontrolled synthesis of phosphonate derivatives of tetrahydro- and dihydro-2H-pyranyl nucleosides: The selectivity of the Ferrier rearrangement

Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.

scientific article published on August 1994

Stereoselective synthesis of (−)-ara-cyclohexenyl-adenine

Stereospecific synthesis of a pentopyranosyl analogue of d4T monophosphate

scientific article published in 1994

Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′-Diyne seco Analogues through Olefin Metathesis Reactions

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Strategies in the Design of Antiviral Drugs

Strategy for the synthesis of pyridazine heterocycles and their derivatives

scientific article published on 31 July 2013

Structural Characterization and Biological Evaluation of Small Interfering RNAs Containing Cyclohexenyl Nucleosides

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Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution

scientific article published on 08 December 2020

Structural Study of Two 5-Heteroaromatic-2′ deoxyuridines and Their 5-Bromine-heteroaromatic Analogues: Theoretical Conformational Analysis and NMR Experiments

scholarly article by Isabelle Creuven et al published March 1997 in Nucleosides & nucleotides

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

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Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy

scientific article published on 5 January 2011

Structural basis for the role of LYS220 as proton donor for nucleotidyl transfer in HIV-1 reverse transcriptase

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Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30.

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Structural requirements for antiviral activity in nucleosides

Structure Determination of the Top-Loop of the Conserved 3′-Terminal Secondary Structure in the Genome of Flaviviruses

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Structure of the alpha-homo-DNA:RNA duplex and the function of twist and slide to catalogue nucleic acid duplexes

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Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC

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Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs

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Structure-Activity Relationship Study of a Potent α-Thrombin Binding Aptamer Incorporating Hexitol Nucleotides

scientific article published on 03 May 2020

Structure-Function Elucidation of a New -Conotoxin, Lo1a, from Conus longurionis

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Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase

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Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase

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Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

scientific article published on May 1999

Studies on Disaccharide Nucleoside Synthesis. Mechanism of the Formation of Trisaccharide Purine Nucleosides

scientific article published on 01 April 1999

Substituted 5-Benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A New Class of Pestivirus Inhibitors

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors

scientific article published on 9 August 2006

Substrate based peptide aldehyde inhibits bacterial type I signal peptidase

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Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

scientific article published on 15 February 2017

Sugar Modified Oligonucleotides

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Sugar and Base-Modified 2',3'-Dideoxynucleosides as Potential Anti-Aids Drugs

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Sulfonate derived phosphoramidates as active intermediates in the enzymatic primer-extension of DNA.

scientific article published on April 2015

Syntheses of 5'-Nucleoside Monophosphate Derivatives with Unique Aminal, Hemiaminal, and Hemithioaminal Functionalities: A New Class of 5'-Peptidyl Nucleotides.

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Synthesis and Activity of Oligonucleotides Containing a Biologically Active Nucleoside at the 2′End

Synthesis and Anti-HIV Activity of Dideoxycytidine Analogues Containing a Pyranose Carbohydrate Moiety

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Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNA

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Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides

scientific article published on 09 July 2020

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine

Synthesis and Antiviral Activity of 1.4-Dioxane, 1.4-Oxathiane and 1,4-Morpholine Nucleoside Analogues

Synthesis and Antiviral Activity of the alpha-Analogues of 1,5-Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy-D-ribohexitol Nucleosides).

scientific article published in April 1997

Synthesis and Antiviral Evaluation of 3'-Substituted Thymidine Analogues Derived from 3'-Amino-3'-deoxythymidine

Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety ⬇️

scientific article published on May 1, 2003

Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers

Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine

Synthesis and Biological Evaluation of Pyrrolo[2,1-f][1,2,4]triazine C-Nucleosides with a Ribose, 2'-Deoxyribose, and 2',3'-Dideoxyribose Sugar Moiety

scientific article published on 21 November 2017

Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides

Synthesis and Conformation of Pentopyranoside Nucleoside Phosphonates

scientific article published on 14 May 2019

Synthesis and Conformational Analysis of 1,5-Anhydro-2,4-dideoxy-D-mannitol Nucleosides

Synthesis and Conformational Analysis of 2?-Deoxy-2?-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

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Synthesis and Conformational Properties of O-β-D-Ribofuranosyl-(1′′-2′)-guanosine and (Adenosine)-5′′-phosphate

Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines

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Synthesis and Pairing Properties of Oligonucleotides Containing 3-Hydroxy-4-hydroxymethyl-1-cyclohexanyl Nucleosides

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Synthesis and Pairing Properties of Oligonucleotides Containing 3-Hydroxy-4-hydroxymethyl-1-cyclohexanyl Nucleosides

Synthesis and Properties of O--D-ribofuranosyl-(1″→2′)-guanosine-5″- O-phosphate and Its Derivatives

scholarly article by Ekaterina V. Efimtseva et al published February 2003 in Helvetica Chimica Acta

Synthesis and Properties of O-β-D-Ribofuranosyl-(1″-2′)-Adenosine-5″-O-Phosphate and Its Derivatives

scholarly article by Andrei A. Rodionov et al published October 2000 in Nucleosides, Nucleotides & Nucleic Acids

Synthesis and Properties of Oligonucleotides Containing 2,4-Dihydroxycyclohexyl Nucleosides

scholarly article by Dorothée Bardiot et al published December 2005 in Helvetica Chimica Acta

Synthesis and Properties of Some 2'-O-d-Ribofuranosyl-nucleosides

Synthesis and Stability of Oligonucleotides Containing Acyclic Achiral Nucleoside Analogues with Two Base Moieties

Synthesis and Structure-Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X

scientific article published on 20 February 2019

Synthesis and anti-HIV activity of guanine modified fluorinated acyclic nucleoside phosphonates derivatives

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Synthesis and anti-herpes activity of 5-trifluorovinyl-2′-deoxyuridine

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Synthesis and anti-herpetic activity of phosphoramidate ProTides

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Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles

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Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.

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Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.

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Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety

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Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines

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Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

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Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.

scientific article published on March 1993

Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides

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Synthesis and antiviral activity of acyclic analogues of 1,5-anhydrohexitol nucleosides using Mitsunobu reaction

Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain

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Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides

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Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

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Synthesis and antiviral evaluation of 3′-substituted thymidine analogues derived from 3′-amino-3′-deoxythymidine

Synthesis and antiviral evaluation of base-modified deoxythreosyl nucleoside phosphonates

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Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.

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Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides

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Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.

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Synthesis and base pairing properties of 1',5'-anhydro-L-hexitol nucleic acids (L-HNA).

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Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides

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Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety

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Synthesis and cleavage experiments of oligonucleotide conjugates with a diimidazole-derived catalytic center

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Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-l-lyxopyranosyl]thymine

scientific article published in June 2004

Synthesis and conformational analysis of a ribo-type cyclohexenyl nucleoside

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Synthesis and conformational behavior of purine and pyrimidine β-d-threo-hex-3'-enopyranosyl nucleosides

Synthesis and conformational properties of O-beta-D-ribofuranosyl-(1''-2')-guanosine and (adenosine)-5''-phosphate

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Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

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Synthesis and evaluation of 5-substituted-2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

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Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.

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Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.

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Synthesis and evaluation of hexitol nucleoside congeners as ambiguous nucleosides

Synthesis and evaluation of novel ligands for the histamine H₄ receptor based on a pyrrolo[2,3-d]pyrimidine scaffold

scientific article published on 15 November 2012

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

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Synthesis and hybridization properties of inverse oligonucleotides.

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Synthesis and in vitro antiviral activities of [(dihydrofuran-2-yl)oxy]methyl-phosphonate nucleosides with 2-substituted adenine as base

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Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators

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Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents

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Synthesis and physicochemical properties of oligonucleotides with an N-cyanoguanidine function instead of the natural phosphate internucleotide linkage

scientific article published in 1993

Synthesis and properties of aminopropyl nucleic acids

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Synthesis and properties of phosphorylated 3'-O-beta-D-ribofuranosyl-2'-deoxythymidine

scientific article published in April 2003

Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties

scientific article published on January 2004

Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.

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Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

scientific article published on 12 June 2019

Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.

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Synthesis of (E)-3′-Phosphonoalkenyl Modified Nucleoside Phosphonates via a Highly Stereoselective Olefin Cross-Metathesis Reaction

Synthesis of .DELTA.3-1-methylene-1-carbacephems

scientific article published on 01 May 1986

Synthesis of 1,5-Anhydro-2-(N6-Cyclopentyladenin-9-Yl)-2-Deoxy-D-Altrohexitol

Synthesis of 1,5-Anhydro-D-Mannitol Nucleosides with a Purine Base Moeety

Synthesis of 1,5-Anhydrohexitol Nucleosides as Mimics of AZT, D4T and DDC

Synthesis of 1,5-anhydrohexitol building blocks for oligonucleotide synthesis

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Synthesis of 2'-N-formamido nucleosides and biological evaluation

scientific article published in November 2009

Synthesis of 2'-O-beta-d-Ribofuranosylnucleosides

scientific article published on January 2007

Synthesis of 2'-cyclohexenylnucleosides and corresponding CeNA building blocks

scientific article published in June 2008

Synthesis of 2,4-dideoxy-.beta.-D-erythro-hexopyranosyl nucleosides

Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase

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Synthesis of 2′-5′ Adenylate Trimers Containing 3′-Modified β-D-Xylofuranosyl-Adenine Derivatives at the 2′-End

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Synthesis of 2′-Deoxy-2′ -Fluoro-D-Arabinopyranopyranosyl Nucleosides and Their 3′,4′-Seco analogues

Synthesis of 2′-O-α-d-ribofuranosyladenosine, monomeric unit of poly(ADP–ribose)

Synthesis of 3'-Amino-3'-deoxyadenosine Derivatives as Potential Drugs for the Treatment of Malaria

scholarly article by Johanna Soenens et al published 1 May 1995 in Nucleosides, Nucleotides & Nucleic Acids

Synthesis of 3'-Fluoro-3'-Deoxyribonucleosides; Anti-HIV-1 and Cytostatic Properties

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Synthesis of 3'-o-phosphonoethyl nucleosides with an adenine and a thymine base moiety

scientific article

Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents

article published in 1998

Synthesis of 3′-Deoxy-3′-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation in Oligonucleotides. Part II 1

article

Synthesis of 3′-Fluoro-3′-deoxy-N6-cyclopentyladenosine

Synthesis of 3′-O-phosphonomethyl nucleosides with an adenine base moiety

Synthesis of 3′-fluoromethylthio-, 3′-fluoromethylsulfinyl- and 3′-fluoromethylsulfonyl-substituted 3′-deoxythymidine

Synthesis of 5′-O-phosphonomethyl-2′,3′-didehydro-2′,3′-dideoxyuridine by use of P-methoxybenzyl as a N3-protecting group

Synthesis of 6-aryl-2′-deoxyuridine nucleosides via a Liebeskind cross-coupling methodology

Synthesis of 9-(3-azido-2,3-dideoxy-β-D--pentofuranosyl)-2,6-diaminopurine (AzddDAP)

article published in 1989

Synthesis of Alanine and Proline Amino Acids with Amino or Guanidinium Substitution on the Side Chain

Synthesis of D-altritol nucleosides with a 3'-O-tert-butyldimethylsilyl protecting group

scientific article published in January 2004

Synthesis of N-methyl-d-ribopyranuronamide nucleosides

scientific article published on 13 August 2008

Synthesis of Nicotinamide Adenine Dinucleotide (NAD) Analogues with a Sugar Modified Nicotinamide Moiety

Synthesis of Novel -substituted guanidine linked nucleoside dimers and their incorporation into oligonucleotides

scientific article published in 1993

Synthesis of Nucleosides Fluorinated in the Sugar Moiety. The Application of Diethylaminosulfur Trifluoride to the Synthesis of Fluorinated Nucleosides

article by Piet Herdewijn et al published January 1989 in Nucleosides & nucleotides

Synthesis of Oligoribonucleotides Containing Pyrimidine 2'-O-[(Hydroxyalkoxy)methyl]ribonucleosides

Synthesis of Peptidoglycan Units with UDP at the Anomeric Position

Synthesis of Protected Amino Hexitol Nucleosides as Building Blocks for Oligonucleotide Synthesis

scientific article published on 07 December 2018

Synthesis of Pyranose Nucleosides

Synthesis of RNA ContainingO-β-D-Ribofuranosyl-(1″2′)-adenosine-5″-phosphate and 1-Methyladenosine, Minor Components of tRNA

scientific article published on 01 September 2005

Synthesis of Thymidine Analogues with a Cyanoimido Substituent

Synthesis of a 2,4,6-trisubstituted 5-cyano-pyrimidine library and evaluation of its immunosuppressive activity in a Mixed Lymphocyte Reaction assay

scientific article

Synthesis of a 3'-Fluoro-3'-deoxytetrose Adenine Phosphonate.

scientific article

Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization

scientific article published on 01 February 2018

Synthesis of a Nucleobase-Modified ProTide Library

scientific article

Synthesis of a Pyridoxine–Peptide Based Delivery System for Nucleotides

Synthesis of a Threosyl‐C‐nucleoside Phosphonate ⬇️

scholarly article

Synthesis of a new branched chain hexopyranosyl nucleoside: 1-[2′,3′-dideoxy-3′-C-(hydroxymethyl)-α-D-erythro-pentopyranosyl]-thymine

Synthesis of altritol nucleoside phosphoramidites for oligonucleotide synthesis

scientific article published on September 2007

Synthesis of an Uncharged cAMP-Analogue

Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity

scientific article published on 20 May 2014

Synthesis of enantiomeric-pure cyclohexenyl nucleoside building blocks for oligonucleotide synthesis

Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons

scientific article published in February 2002

Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase.

scientific article

Synthesis of new acyclic nucleoside phosphonates (ANPs) substituted on the 1′ and/or 2′ positions

Synthesis of new biocarrier–nucleotide systems for cellular delivery in bacterial auxotrophic strains

article

Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors

scientific article

Synthesis of nucleoside analogues with a 1,5-anhydrohexitol moiety

article published in 1993

Synthesis of oligonucleotides modified in the sugar moiety.

scientific article published in January 1991

Synthesis of protected D-altritol nucleosides as building blocks for oligonucleotide synthesis

Synthesis of ribonucleosides by condensation using trimethylsilyl triflate

scientific article published on January 2007

Synthesis of the Anticodon HairpintRNAfMet ContainingN-{[9-(β-D-Ribofuranosyl)-9H-purin-6-yl]carbamoyl}-L-threonine (=N6-{{[(1S,2R)-1-Carboxy-2-hydroxypropyl]amino}carbonyl}adenosine, t6A)

scholarly article by Valerie Boudou et al published 19 January 2000 in Helvetica Chimica Acta

Synthesis of the β-2',3'-Unsaturated Pentopyranosyl Nucleosides and Their 3'-Hydroxymethyl Congeners

Synthesis of thymidine from 5-iodo-2′-deoxyuridine

Synthesis of α-L-threose nucleoside phosphonates via regioselective sugar protection

scientific article published on 3 July 2013

Synthesis of β configured 2′,3′-unsaturated pentopyranosyl nucleosides

Synthesis, Biological Activity, and Molecular Modeling of Ribose-Modified Deoxyadenosine Bisphosphate Analogues as P2Y1Receptor Ligands

article

Synthesis, and in vitro enzymatic and antiviral evaluation of d4T polyphosphate derivatives as chain terminators

scientific article

Synthesis, enzymatic stability and physicochemical properties of oligonucleotides containing a N-cyanoguanidine linkage

Synthesis, immunosuppressive activity and structure-activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues

scientific article published on 4 January 2010

Synthesis, solution conformations and hydrolytic stability of 3'-substituted 2'-deoxyribonucleosides ⬇️

scientific article published on January 1, 1991

Synthetic Strategies Towards the Synthesis of 1–(2,4-Dideoxy-4-C-hydroxymethyl-α-L-Lyxopyranosyl)base Nucleosies

Synthetic dsDNA-Binding Peptides Using Natural Compounds as Model

scholarly article by Filip Borgions et al published June 2006 in Helvetica Chimica Acta

Synthetic genetic polymers capable of heredity and evolution

scientific article

T. cruzi OligoC-TesT: a simplified and standardized polymerase chain reaction format for diagnosis of Chagas disease

scientific article

TNA as a Potential Alternative to Natural Nucleic Acids

scientific article published on 01 June 2001

Targeting RNA with Conformationally Restricted Oligonucleotides

Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues

scientific article published on 23 December 2020

The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication

scientific article

The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro

scientific article published on May 1987

The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair

article

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

scientific article (publication date: October 2007)

The N1-(3'-Deoxythymidin-3'-yl)-N2-cyano-N3-(5'-deoxythymidin-5'-yl) Guanidine Dimeric Building Block in Automated DNA Synthesis and Mass Spectrometric Analysis of Its Integrity

article published in 1995

The Network of Replication, Transcription, and Reverse Transcription of a Synthetic Genetic Cassette

scientific article published on 03 November 2020

The alpha-L-ribo-isomers of RNA and LNA (locked nucleic acid)

scientific article published on 01 January 2001

The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure

scientific article

The crystal structure of the CeNA:RNA hybrid ce(GCGTAGCG):r(CGCUACGC)

scientific article

The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine

scientific article

The effect of addition of carbon powder to samples in liquid secondary ion mass spectrometry: Improved ionization of apolar compounds

article

The interplay between antiviral activity, oligonucleotide hybridisation and nucleic acids incorporation studies

scientific article

The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target

scientific article published on October 2010

The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif

scientific article published on 31 May 2006

The synthesis of modified D- and L-anhydrohexitol nucleosides

Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group

scientific article published on 22 March 2016

Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors

scientific article published on 21 May 2016

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

scientific article published in September 2003

Toward safe genetically modified organisms through the chemical diversification of nucleic acids

scientific article

Towardl-Homo-DNA: Stereoselective de Novo Synthesis of β-l-erythro-Hexopyranosyl Nucleosides

scientific article published on 01 October 2010

Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

scientific article published on November 1996

Unexpected Shift to a 4-Imino Tautomer Upon N4-Acylation of 5-Methylcytosin-1-yl Nucleoside Analogues

Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides

Use of RNA in drug design

scientific article published on June 2007

Vitamin-guanosine monophosphate conjugates for in vitro transcription priming

scientific article published on 01 March 2020

What Is XNA?

scientific article published on 19 July 2019

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties

scientific article published on 14 July 2015

[Structure-activity relation study of anti-herpes associations with a 2'-deoxyuridine basic structure]

scientific article published on 01 January 1995

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties

scientific article

d(GCGTAGC), an Equilibrium Between a Hairpin Structure and an Unusual Duplex

α-Homo-DNA and RNA Form a Parallel Oriented Non-A, Non-B-Type Double Helical Structure

γ-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents

scientific article published on 7 October 2014

List of works by Piet Herdewijn

(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity

1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro

1,2;3,4-Di-O-isopropylidene-l-galactose synthesis from its d-enantiomer

1,5-Anhydro-2-Deoxy-D-Altritol Oligonucleotides as Conformationally Restricted Analogues of Rna

1-(2,3-Dideoxy-erythro-beta-D-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase

1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

1′,5′-Anhydro-l-ribo-hexitol Adenine Nucleic Acids (α-l-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World

1′,5′-Anhydrohexitol Oligonucleotides: Hybridisation and Strand Displacement with Oligoribonucleotides, Interaction with RNase H and HIV Reverse Transcriptase

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

2'-Deoxyribonucleoside phosphoramidate triphosphate analogues as alternative substrates for E. coli polymerase III.

2'-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides

2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.

3′-Amidated 3′-Deoxyxylofuranose Analogues of N 6-−Cyclopentyladenosines: a New Class of Non-Xanthine Antagonists at the Adenosine A1 Receptor

3′-Deoxy-3′-hydroxymethyl-aldopentopyranosyl nucleoside synthesis. Part I

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

5-Hydroxytryptophan as a building block in oligopeptides using Fmoc/tBu SPPS

5-Substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo

A Methyl Group Controls Conformational Equilibrium in Human Mitochondrial tRNALys

A Novel and Enantioselective Approach to the Synthesis of Cyclohexane Carbocyclic Nucleosides Starting from (-)-Carvone

A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics ⬇️

A Potential Prebiotic Route to Adenine from Hypoxanthine

A Single Amino Acid Substitution in Therminator DNA Polymerase Increases Incorporation Efficiency of Deoxyxylonucleotides

A Straightforward Stereoselective Synthesis of d- and l-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanine ⬇️

A Versatile NMR Technique for the Identification of Phosphorylation Sites in Oligosaccharides

A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro

A highly enantio-selective hexitol nucleic acid template for nonenzymatic oligoguanylate synthesis.

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

A novel and convenient strategy for the synthesis of phthalazines from an aryne precursor

A novel helper phage for HaloTag-mediated co-display of enzyme and substrate on phage

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

A short and convenient strategy for the synthesis of pyridazines via Diaza–Wittig reaction

A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides

A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis

A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates

Access to a New Type of Homo-C-Nucleosides with a “Split” 8-Deazapurine via a 1,3-Dipolar Cycloaddition Reaction

Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer

Acyclic oligonucleotides: possibilities and limitations

Additions and Corrections - Resolution of Aristeromycin Enantiomers

Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA.

Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.

Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.

Amidate Prodrugs of Cyclic 9-()-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication

Amino Acid Phosphoramidate Nucleotides as Alternative Substrates for HIV-1 Reverse Transcriptase

Amino acids derived from ornithine

Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants

An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside

An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides

Antibacterial 5'-O-(N-dipeptidyl)-sulfamoyladenosines.

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

Antimalarial antisense activity of hexitol nucleic acids

Antisense oligonucleotides

Application of the Mitsunobu-Type Condensation Reaction to the Synthesis of Phosphonate Derivatives of Cyclohexenyl and Cyclohexanyl Nucleosides

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.

Base pairing involving artificial bases in vitro and in vivo.

Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA).

Base-Modified Nucleic Acids as a Powerful Tool for Synthetic Biology and Biotechnology

Base−Base Interactions in the Minor Groove of Double-Stranded DNA

Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity

Binary genetic cassettes for selecting XNA-templated DNA synthesis in vivo

Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

Branched-chain nucleosides: Synthesis of 3′-deoxy-3′-C- hydroxymethyl-α-l-lyxopyranosyl thymine and 3′-deoxy- 3′-C-hydroxymethyl-α-l-threofuranosyl thymine

Carbohydrate chiral-pool approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates