List of works - Houman Ashrafian

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy

scientific journal article

A review of the causes of central pontine myelinosis: yet another apoptotic illness?

scientific article

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia

scientific article published on 2 May 2013

AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes

scientific article

Adenosine stress native T1 mapping in severe aortic stenosis: evidence for a role of the intravascular compartment on myocardial T1 values

scientific article

Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models.

scientific article

Antimicrobial prophylaxis for endocarditis: emotion or science?

scientific article

Assessing myocardial perfusion after myocardial infarction

scientific article

Beta-blocker therapy of cardiovascular diseases in patients with bronchial asthma or COPD: the pro viewpoint.

scientific article

Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis

scientific article

Cardiac steatosis and left ventricular remodeling in heart failure with reduced and preserved ejection fraction.

scientific article published on 3 February 2015

Carotid ultrasound imaging: an effective technique for detecting early atherosclerosis-vascular screening for cardiovascular disease has come of age.

scientific article published on January 2007

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy

article

Citric acid cycle intermediates in cardioprotection

scientific article

Detecting acute coronary syndrome in the emergency department: the answer is in seeing the heart: why look further?The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Societ

scientific article published on 21 June 2005

Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy

scientific article published on June 2011

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

scientific article published on 21 July 2010

Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction

scientific article

Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name?

scientific article published on 01 October 2008

Expression of human papillomavirus type 16 L1 protein in Escherichia coli: denaturation, renaturation, and self-assembly of virus-like particles in vitro

scientific article published on April 1998

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis

scientific article published on 26 October 2010

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

scientific article published in March 2012

Genetic cardiomyopathies causing heart failure

scientific article published on August 2013

Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE)

scientific article published on 3 January 2011

Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.

scientific article published in July 2009

Hepcidin: the missing link between hemochromatosis and infections

scientific article published on December 2003

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion

scientific article

Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans

scientific article published on 22 January 2008

Impaired energetics in heart failure - a new therapeutic target.

scientific article published on 17 June 2008

In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration

article published in 2011

In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart

scientific article published on 16 May 2012

In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy

scientific article published on 18 February 2013

Increased left atrial volume index is an independent predictor of raised serum natriuretic peptide in patients with suspected heart failure but normal left ventricular ejection fraction: Implication for diagnosis of diastolic heart failure

scientific article published on 22 August 2005

Inherited Cardiomyopathies

Inherited cardiomyopathies

Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach.

scientific article published on 19 February 2009

Metabolic Modulation in Heart Failure: The Coming of Age

scientific article published on 01 February 2007

Metabolic mechanisms in heart failure

scientific article published on July 2007

Metabolic modulation in heart failure: high time for a definitive clinical trial

scientific article published on 01 February 2011

Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment

scientific article

Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.

scientific article published on 4 October 2010

Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy

Metabolomic Profiling of Cardiac Substrate Utilization

scientific article published on 01 April 2009

Myocardial perfusion and oxygenation are impaired during stress in severe aortic stenosis and correlate with impaired energetics and subclinical left ventricular dysfunction

scientific article

Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis

scientific article published on 5 July 2013

Natriuretic peptides, respiratory disease, and the right heart

scientific article published in October 2004

No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure.

scientific article

Once you start, you can't stop

scientific article published in The Lancet

Perhexiline

scientific article published on January 2007

Potentiating mitochondrial aldehyde dehydrogenase 2 to treat post-infarction heart failure

scientific article published on 04 August 2014

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

scientific article published on 26 July 2010

Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing

scientific article published in January 2007

Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

scientific article

Remote ischemic preconditioning with--but not without--metabolic support protects the neonatal porcine heart against ischemia-reperfusion injury.

scientific article published on 12 November 2013

Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism

scientific article published on 01 April 2004

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure ⬇️

scientific article published on 14 September 2015

Response to Letter Regarding Article, “Glucose-Insulin-Potassium Reduces the Incidence of Low Cardiac Output Episodes After Aortic Valve Replacement for Aortic Stenosis in Patients With Left Ventricular Hypertrophy: Results From the Hypertrophy, In

Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype

scientific article published on 9 March 2007

Screening for isolated diastolic dysfunction ? a bridge too far?

scientific article published on 01 March 2005

Severe aortic stenosis has blunted myocardial T1 relaxation response to vasodilator stress: a cardiac magnetic resonance adenosine stress test study.

scientific article published on 3 February 2015

Severe hypercalcaemia from secretion of parathyroid hormone-related peptide

scientific article published on 01 October 2004

Successful emergency coronary surgery for intractable ventricular fibrillation without prior angiography

scientific article published on 01 July 2000

Targets for therapy in sarcomeric cardiomyopathies

scientific article

The genetics of hypertrophic cardiomyopathy: Teare redux

scientific article published on 24 July 2008

The natriuretic peptides and their role in disorders of right heart dysfunction and pulmonary hypertension

scientific article published in October 2004

The role of vascular myoglobin in nitrite-mediated blood vessel relaxation ⬇️

scientific article

Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems

scientific article published on 3 October 2008

List of works by Houman Ashrafian

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy

A review of the causes of central pontine myelinosis: yet another apoptotic illness?

A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia

AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes

Adenosine stress native T1 mapping in severe aortic stenosis: evidence for a role of the intravascular compartment on myocardial T1 values

Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models.

Antimicrobial prophylaxis for endocarditis: emotion or science?

Assessing myocardial perfusion after myocardial infarction

Beta-blocker therapy of cardiovascular diseases in patients with bronchial asthma or COPD: the pro viewpoint.

Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis

Cardiac steatosis and left ventricular remodeling in heart failure with reduced and preserved ejection fraction.

Carotid ultrasound imaging: an effective technique for detecting early atherosclerosis-vascular screening for cardiovascular disease has come of age.

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy

Citric acid cycle intermediates in cardioprotection

Detecting acute coronary syndrome in the emergency department: the answer is in seeing the heart: why look further?The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Societ

Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.

Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction

Exercise-induced ventricular dysfunction in hypertrophic cardiomyopathy: stunning by any other name?

Expression of human papillomavirus type 16 L1 protein in Escherichia coli: denaturation, renaturation, and self-assembly of virus-like particles in vitro

Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

Genetic cardiomyopathies causing heart failure

Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE)

Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.

Hepcidin: the missing link between hemochromatosis and infections

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion

Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans

Impaired energetics in heart failure - a new therapeutic target.

In silico studies on the sensitivity of myocardial PCr/ATP to changes in mitochondrial enzyme activity and oxygen concentration

In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart

In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy

Increased left atrial volume index is an independent predictor of raised serum natriuretic peptide in patients with suspected heart failure but normal left ventricular ejection fraction: Implication for diagnosis of diastolic heart failure

Inherited Cardiomyopathies

Inherited cardiomyopathies

Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach.

Metabolic Modulation in Heart Failure: The Coming of Age

Metabolic mechanisms in heart failure

Metabolic modulation in heart failure: high time for a definitive clinical trial

Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment

Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.

Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy

Metabolomic Profiling of Cardiac Substrate Utilization

Myocardial perfusion and oxygenation are impaired during stress in severe aortic stenosis and correlate with impaired energetics and subclinical left ventricular dysfunction

Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis

Natriuretic peptides, respiratory disease, and the right heart

No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure.

Once you start, you can't stop

Perhexiline

Potentiating mitochondrial aldehyde dehydrogenase 2 to treat post-infarction heart failure

Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Regression of dilated-hypokinetic hypertrophic cardiomyopathy by biventricular cardiac pacing

Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

Remote ischemic preconditioning with--but not without--metabolic support protects the neonatal porcine heart against ischemia-reperfusion injury.

Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure ⬇️

Response to Letter Regarding Article, “Glucose-Insulin-Potassium Reduces the Incidence of Low Cardiac Output Episodes After Aortic Valve Replacement for Aortic Stenosis in Patients With Left Ventricular Hypertrophy: Results From the Hypertrophy, In

Reviews of translational medicine and genomics in cardiovascular disease: new disease taxonomy and therapeutic implications cardiomyopathies: therapeutics based on molecular phenotype

Screening for isolated diastolic dysfunction ? a bridge too far?

Severe aortic stenosis has blunted myocardial T1 relaxation response to vasodilator stress: a cardiac magnetic resonance adenosine stress test study.

Severe hypercalcaemia from secretion of parathyroid hormone-related peptide

Successful emergency coronary surgery for intractable ventricular fibrillation without prior angiography

Targets for therapy in sarcomeric cardiomyopathies

The genetics of hypertrophic cardiomyopathy: Teare redux

The natriuretic peptides and their role in disorders of right heart dysfunction and pulmonary hypertension

The role of vascular myoglobin in nitrite-mediated blood vessel relaxation ⬇️

Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems