List of works - Gioacchino Natoli

Macrophage activation and polarization: nomenclature and experimental guidelines

scientific article (publication date: 17 July 2014)

Transcriptional regulation of macrophage polarization: enabling diversity with identity

scientific article published on 25 October 2011

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

scientific article

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

scientific article

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

scientific journal article

Trained immunity: A program of innate immune memory in health and disease.

scientific article

A large fraction of extragenic RNA pol II transcription sites overlap enhancers

scientific article

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.

scientific article published on 4 March 2010

p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment

scientific article published on 17 December 2001

Latent enhancers activated by stimulation in differentiated cells

scientific article

Transcriptional regulation via the NF-kappaB signaling module.

scientific article published on October 2006

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

scientific article

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

scholarly article

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

scientific article published on 24 September 2009

Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions

scientific article

Two waves of nuclear factor kappaB recruitment to target promoters

scientific article

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma

scientific article published on March 2013

Noncoding Transcription at Enhancers: General Principles and Functional Models

scientific article published on August 16, 2012

Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes

scientific article published on 25 November 2002

Macrophages and cancer: from mechanisms to therapeutic implications

scientific article published on 11 March 2015

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

scientific article

Modulation of NF-kappaB activity by exchange of dimers

scientific article

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

scientific article published on November 2000

Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response

scientific article

Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time

scientific article

Molecular control of activation and priming in macrophages

scientific article

The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment

scientific article

A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity

scientific article

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression

scientific journal article

The hepatitis B virus X gene induces p53-mediated programmed cell death

scientific article

Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes

scientific article published on September 2002

Maintaining cell identity through global control of genomic organization

scientific article published on July 2010

Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX

scientific article published on February 1994

Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers.

scientific article

Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs

scientific article

Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2

scientific journal article

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.

scientific article

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

scientific article published on 01 October 1998

The genomic landscapes of inflammation.

scientific article published on January 2011

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

scientific article

Control of NF-kappaB-dependent transcriptional responses by chromatin organization

scientific article published on October 2009

Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk

scientific article published on 13 March 2017

Chromatin contributions to the regulation of innate immunity

scientific article published on 06 February 2014

Nuclear ubiquitin ligases, NF-kappaB degradation, and the control of inflammation

scientific article published on 08 January 2008

The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival.

scientific article

A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages

scientific article

Reactive Oxygen Intermediates Mediate Angiotensin II-induced c-Jun•c-Fos Heterodimer DNA Binding Activity and Proliferative Hypertrophic Responses in Myogenic Cells

scientific article published on September 22, 1995

NF‐κB and chromatin: ten years on the path from basic mechanisms to candidate drugs

scientific article published on March 1, 2012

The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis

scientific article published on 5 April 2012

Two modes of transcriptional activation at native promoters by NF-kappaB p65

scientific article

List of works by Gioacchino Natoli

Macrophage activation and polarization: nomenclature and experimental guidelines

Transcriptional regulation of macrophage polarization: enabling diversity with identity

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

Trained immunity: A program of innate immune memory in health and disease.

A large fraction of extragenic RNA pol II transcription sites overlap enhancers

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.

p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment

Latent enhancers activated by stimulation in differentiated cells

Transcriptional regulation via the NF-kappaB signaling module.

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions

Two waves of nuclear factor kappaB recruitment to target promoters

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma

Noncoding Transcription at Enhancers: General Principles and Functional Models

Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes

Macrophages and cancer: from mechanisms to therapeutic implications

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

Modulation of NF-kappaB activity by exchange of dimers

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response

Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time

Molecular control of activation and priming in macrophages

The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment

A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression

The hepatitis B virus X gene induces p53-mediated programmed cell death

Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes

Maintaining cell identity through global control of genomic organization

Induction of the DNA-binding activity of c-jun/c-fos heterodimers by the hepatitis B virus transactivator pX

Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers.

Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs

Nuclear factor kB-independent cytoprotective pathways originating at tumor necrosis factor receptor-associated factor 2

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

The genomic landscapes of inflammation.

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

Control of NF-kappaB-dependent transcriptional responses by chromatin organization

Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk

Chromatin contributions to the regulation of innate immunity

Nuclear ubiquitin ligases, NF-kappaB degradation, and the control of inflammation

The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival.

A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages

Reactive Oxygen Intermediates Mediate Angiotensin II-induced c-Jun•c-Fos Heterodimer DNA Binding Activity and Proliferative Hypertrophic Responses in Myogenic Cells

NF‐κB and chromatin: ten years on the path from basic mechanisms to candidate drugs

The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis

Two modes of transcriptional activation at native promoters by NF-kappaB p65