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List of works by Wenjian Qian

Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides

scientific article published in January 2011

Construction of multiring frameworks by metal-free cascade reactions of stable isochromenylium tetrafluoroborate.

scientific article published in November 2009

Design and Synthesis of Fmoc-Thr[PO(OH)(OPOM)] for the Preparation of Peptide Prodrugs Containing Phosphothreonine in Fully Protected Form

scientific article published on 01 May 2014

Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.

scientific article published on 02 August 2013

Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position.

scientific article

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification ⬇️

scientific article published on February 14, 2012

Investigation of unanticipated alkylation at the N(π) position of a histidyl residue under Mitsunobu conditions and synthesis of orthogonally protected histidine analogues

scientific article published on 3 October 2011

Mitsunobu mischief: neighbor-directed histidine N(τ)-alkylation provides access to peptides containing selectively functionalized imidazolium heterocycles

scientific article

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.

scientific article published on November 2014

Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles

scientific article (publication date: November 2015)

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).

scientific article

Peptoid–Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo‐Like Kinase 1 ⬇️

scientific article published on May 8, 2012

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

scientific article

Total Synthesis, Assignment of Absolute Stereochemistry, and Structural Revision of Chlorofusin

scientific article published on 02 May 2007

Transformation of Reactive Isochromenylium Intermediates to Stable Salts and Their Cascade Reactions with Olefins

scientific article published on 01 October 2009

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