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List of works by John G. Flannery

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells

scientific article

AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa

scientific article published on 26 April 2011

AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers

scientific article published on 31 December 2013

AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina

scientific article

Activation of specific interneurons improves V1 feature selectivity and visual perception

scientific article

Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina

scientific article published on 21 May 2015

Advances in AAV vector development for gene therapy in the retina

scientific article published on January 2014

Alternative splice variants of the USH3A gene Clarin 1 (CLRN1)

scientific article

Anti-clarin-1 AAV-delivered ribozyme induced apoptosis in the mouse cochlea.

scientific article published on 5 April 2007

Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates

scientific article published on 11 December 2014

Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.

scientific article published on 13 March 2018

CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development

scientific article

CRALBP supports the mammalian retinal visual cycle and cone vision

scientific article

Changes in adeno-associated virus-mediated gene delivery in retinal degeneration

scientific article published on May 2010

Characterization of peripherin/rds and rom-1 transport in rod photoreceptors of transgenic and knockout animals

scientific article

Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton

scientific article

Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9.

scientific article published on 20 October 2011

Evaluation of patient-centered rehabilitation model targeting older persons with a hip fracture, including those with cognitive impairment

scientific article

Gene delivery to the retina using lentiviral vectors

scientific article published in January 2006

Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models

scientific article published on 20 February 2015

Imaging light responses of foveal ganglion cells in the living macaque eye.

scientific article

In vivo imaging of microscopic structures in the rat retina

scientific article published on 2 July 2009

In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous

scientific article published in June 2013

Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous

scientific article published in 2009

Intravitreal injection of AAV2 transduces macaque inner retina

scientific article

LiGluR restores visual responses in rodent models of inherited blindness

scientific article

Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve

scientific article published on 27 November 2012

Looking within for vision

scientific article published in April 2006

Massively parallel cis-regulatory analysis in the mammalian central nervous system

scientific article (publication date: February 2016)

Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve.

scientific article

Molecular evolution of adeno-associated virus for enhanced glial gene delivery

scientific article published on 11 August 2009

Mutation-Independent Gene Therapies for Rod-Cone Dystrophies.

scientific article

Neuron-glia signaling in developing retina mediated by neurotransmitter spillover

scientific article

Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina.

scientific article

Noncontact transscleral neodymium-YAG laser photocoagulation of the pigmented rabbit retina

scientific article published on March 1, 1992

North Carolina macular dystrophy: clinicopathologic correlation

scientific article published on 01 December 2001

Notch suppression collaborates with Ascl1 and Lin28 to unleash a regenerative response in fish retina, but not in mice

scientific article published on 29 January 2018

Oblique-plane single-molecule localization microscopy for tissues and small intact animals

scientific article published on 19 August 2019

Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin

scientific article published in January 2018

Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity

scientific article

Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration

scientific article published on 6 November 2017

Publisher Correction: Oblique-plane single-molecule localization microscopy for tissues and small intact animals

scientific article published on 01 October 2019

Quantitative analyses of retinal vascular area and density after different methods to reduce VEGF in a rat model of retinopathy of prematurity

scientific article published on 04 February 2014

Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium

scientific article

Remote control of neuronal activity with a light-gated glutamate receptor

scientific article

Restoration of high-sensitivity and adapting vision with a cone opsin

scientific article published on 15 March 2019

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

scientific article published on 30 November 2017

Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

scientific article

Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase beta subunit ⬇️

scientific article published on May 15, 1992

Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse.

scientific article published on 3 April 2014

Ribozyme gene therapy for autosomal dominant retinal disease.

scientific article published in February 2000

Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy.

scientific article

Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.

scientific article published in August 1998

Role for a novel Usher protein complex in hair cell synaptic maturation

scientific article published on 17 February 2012

Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas

scientific article published in January 2018

Severe retinal degeneration caused by a novel rhodopsin mutation.

scientific article

Short hairpin RNA-mediated knockdown of VEGFA in Müller cells reduces intravitreal neovascularization in a rat model of retinopathy of prematurity

scientific article published on September 2013

Specific tools for targeting and expression in Müller glial cells

scientific article published on 19 March 2014

Structure and Function of Rod Photoreceptors

Systemic aminoglycoside treatment in rodent models of retinitis pigmentosa.

scientific article published on 3 June 2008

Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.

scientific article published on 2 February 2014

Targeted transgene expression in muller glia of normal and diseased retinas using lentiviral vectors

scientific article published in April 2007

Targeting Müller cell-derived VEGF164 to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity

scientific article published on 10 February 2014

The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age

scientific article published on 16 September 2014

Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice ⬇️

scientific article published on February 1, 1991

Transgenic Animal Models for the Study of Inherited Retinal Dystrophies.

scientific article published in January 1999

Transport of truncated rhodopsin and its effects on rod function and degeneration

scientific article

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina.

scientific article published on 5 September 2017

USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses

scientific article

Uptake, processing and release of retinoids by cultured human retinal pigment epithelium

article

Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation

scientific article

Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization

scientific article

Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration

scientific article published in January 2003

Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

scientific article

Viral-vectored ribozymes as therapy for autosomal dominant retinal disease

article

Visual stimulation switches the polarity of excitatory input to starburst amacrine cells

scientific article

Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas

scientific article published on September 2016

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