List of works - Stephane Betzi

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

scientific article published on 15 March 2016

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

scientific article

A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

scientific article

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

scientific article

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

scientific article

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

scientific article

Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

scientific article

Discovery of a Potential Allosteric Ligand Binding Site in CDK2

scientific article

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

scientific article published on 10 November 2017

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

scientific article

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space

scientific article

Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)

scientific article

GFscore: a general nonlinear consensus scoring function for high-throughput docking

scientific article

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

scientific article

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

scientific article

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

scientific article published on 22 June 2018

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

scientific article

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

scientific article

Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions.

scientific article

Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments

scientific article

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

scientific article

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery

scientific article

Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.

scientific article

Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2

scientific article published on 19 January 2015

Stereoselective synthesis of original spirolactams displaying promising folded structures.

scientific article published on 13 June 2013

Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer

scientific article

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

scientific article

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

scientific article

The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),

scientific article

List of works by Stephane Betzi

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein-protein interactions.

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity

Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases

Discovery of a Potential Allosteric Ligand Binding Site in CDK2

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space

Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)

GFscore: a general nonlinear consensus scoring function for high-throughput docking

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions.

Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery

Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.

Stability of the human Hsp90-p50Cdc37 chaperone complex against nucleotides and Hsp90 inhibitors, and the influence of phosphorylation by casein kinase 2

Stereoselective synthesis of original spirolactams displaying promising folded structures.

Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane

The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP- N -Acetylglucosamine 1-Carboxyvinyltransferase (MurA),