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List of works by Steve Ward

4-Aminoquinolines--past, present, and future: a chemical perspective

scientific article published on January 1998

<i>Wolbachia</i> depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment

scientific article published on 04 April 2022

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

scientific article

A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.

scientific article

A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum

scientific article published on January 1998

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

scientific article published on 9 June 2005

A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.

scientific article

A rapid and sensitive HPLC–MS method for the detection of plasma and cellular rifampicin

scientific article published on 10 July 2007

A simple breath test for tuberculosis using ion mobility: A pilot study.

scientific article

A simultaneous population pharmacokinetic analysis of rifampicin in Malawian adults and children.

scientific article published on 27 November 2015

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

scientific article published on 24 May 2017

A yeast expression system for functional and pharmacological studies of the malaria parasite Ca²⁺/H⁺ antiporter.

scientific article

AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.

scientific article published on 8 November 2002

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.

scientific article published on 23 October 2017

Altered binding of chloroquine to ferriprotoporphyrin IX is the basis for chloroquine resistance.

scientific article published on April 1999

Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine

scientific article published on September 1996

An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity.

scientific article

Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1

scientific article

Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes

scientific article published on 20 November 2012

Antimalarial activity of primaquine operates via a two-step biochemical relay

scientific article published on 19 July 2019

Antimalarial chemotherapy: young guns or back to the future? ⬇️

scientific article published on November 1, 2003

Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance.

scientific article published on February 2007

Antimalarial pharmacology and therapeutics of atovaquone

scientific article

Antitubercular pharmacodynamics of phenothiazines

scientific article published on 9 December 2012

Antitumour and antimalarial activity of artemisinin-acridine hybrids.

scientific article

Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore

scientific article published on 01 September 2004

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

scientific article published on 8 February 2016

Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum.

scientific article

Biguanide-atovaquone synergy against Plasmodium falciparum in vitro

scientific article published on August 2002

Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical

scientific article published on 01 March 2000

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

scientific article published on 26 February 2019

CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives

scientific article

CRIMALDDI: a prioritized research agenda to expedite the discovery of new anti-malarial drugs.

scientific article

CRIMALDDI: platform technologies and novel anti-malarial drug targets

scientific article

Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.

scientific article

Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs.

scientific article

Chloroquine resistance before and after its withdrawal in Kenya

scientific article published on 18 May 2009

Chloroquine resistance of Plasmodium falciparum: further evidence for a lack of association with mutations of the pfmdr1 gene

scientific article published on November 1994

Chloroquine sensitivity of Plasmodium falciparum in vivo in a savanna town in Cameroon.

scientific article published on May 1992

Clinical status and implications of antimalarial drug resistance.

scientific article published on February 2002

Coartem (artemether-lumefantrine) in Africa: the beginning of the end?

scientific article published in October 2005

Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.

scientific article published in January 2009

Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial

scientific article published on June 2004

Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine

scientific article published on 19 September 2011

Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis

scientific article

Could proteomic research deliver the next generation of treatments for pneumococcal meningitis?

scientific article published on 27 May 2009

Current drug development portfolio for antimalarial therapies.

scientific article

Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance

scientific article published on June 1990

Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression

scientific article published on 26 January 2012

Dangerous midwives and hemoglobin degradation: a response

scholarly article published by Ernst Hempelmann in 2003

Definitive proof for a role of pfmdr 1 in quinoline resistance in Plasmodium falciparum.

scientific article

Design and synthesis of endoperoxide antimalarial prodrug models.

scientific article

Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.

scientific article published on 20 May 2008

Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin

scientific article published on 03 November 2006

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

scientific article published on 23 February 2010

Determination of arteether in blood plasma by high-performance liquid chromatography with ultraviolet detection after hydrolysis acid

scientific article published on 01 August 1989

Determination of artelinic acid in blood plasma by high-performance liquid chromatography

scientific article published on 01 October 1989

Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children

scientific article published in July 2005

Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.

scientific article

Development of a High-Throughput Cytometric Screen to Identify Anti- Wolbachia Compounds: The Power of Public-Private Partnership

scientific article published on 08 April 2019

Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit.

scientific article published in December 2004

Diagnostics for schistosomiasis in Africa and Arabia: a review of present options in control and future needs for elimination

scientific article

Diethylcarbamazine disposition in patients with onchocerciasis

scientific article published on 01 October 1981

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity

scientific article published on 28 February 2019

Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay

scientific article

Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH.

scientific article

Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.

scientific article published on 14 January 2008

Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes

scientific article published on March 1993

Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat.

scientific article published on March 1993

Effect of the progestogens, gestodene, 3-keto desogestrel, levonorgestrel, norethisterone and norgestimate on the oxidation of ethinyloestradiol and other substrates by human liver microsomes

scientific article published in February 1991

Effects of dosage, comorbidities, and food on isoniazid pharmacokinetics in Peruvian tuberculosis patients

scientific article

Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya

scientific article

Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin.

scientific article published on January 1997

Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

scientific article (publication date: 24 September 2004)

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.

scientific article

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials

scientific article

Exploring pancreatic pathology in Plasmodium falciparum malaria patients.

scientific article published on 11 July 2018

Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria

scientific article (publication date: May 2006)

Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4.

scientific article

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

scientific article

Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis

scientific article

Global proteomic analysis of plasma from mice infected with Plasmodium berghei ANKA using two dimensional gel electrophoresis and matrix assisted laser desorption ionization-time of flight mass spectrometry.

scientific article

Glutathione transport: a new role for PfCRT in chloroquine resistance

scientific article (publication date: September 2013)

Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite.

scientific article published on 06 March 2009

HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.

scientific article

Heme binding contributes to antimalarial activity of bis-quaternary ammoniums

scientific article

Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library

scientific article published on 27 September 2017

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

scientific article

Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.

scientific article

Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

scientific article published on 24 February 2012

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

scientific article

In vitro antimalarial drug susceptibility in Thai border areas from 1998-2003.

scientific article

In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1.

scientific article published on December 1996

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

scientific article published on 05 August 2019

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

scientific article published in Nature Communications

Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum.

scientific article published on 2 January 2017

Inter-individual variation in the metabolic activation of the antimalarial biguanides

scientific article published on May 1991

Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients

scientific article published on 23 August 2018

Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid

scientific article published on 01 February 2019

Intracellular PD Modelling (PDi) for the Prediction of Clinical Activity of Increased Rifampicin Dosing

scientific article published on 13 June 2019

Is reversal of chloroquine resistance ready for the clinic?

scientific article published on March 2001

Isoquine and Related Amodiaquine Analogues: A New Generation of Improved 4-Aminoquinoline Antimalarials ⬇️

scientific article published on November 6, 2003

Lack of effect of halofantrine on hepatic drug metabolism in the rat in vivo and in vitro

scientific article published on 01 May 1990

Low levels of pyrazinamide and ethambutol in children with tuberculosis and impact of age, nutritional status, and human immunodeficiency virus infection.

scientific article

Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria

scientific article published on 18 November 2015

Malaria chemotherapy.

scientific article

Malaria parasite transporters as a drug-delivery strategy.

scientific article

Malaria-parasite mitochondrial dehydrogenases as drug targets: too early to write the obituary.

scientific article

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi

scientific article published on 26 August 2009

Mechanisms of chloroquine resistance in malarial chemotherapy

scientific article published on July 1988

Metabolism of gestodene in human liver cytosol and microsomes in vitro

scientific article published on 01 August 1993

Metabolite footprinting of Plasmodium falciparum following exposure to Garcinia mangostana Linn. crude extract.

scientific article

Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.

scientific article published on 21 March 2016

Modelling of Systemic versus Pulmonary Chloroquine Exposure in Man for COVID-19 Dose Selection

scientific article published on 30 April 2020

Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

scientific article published on January 2010

Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP.

scientific article

Molecular cloning of a gene encoding a 20S proteasome beta subunit from Plasmodium falciparum

scientific article (publication date: May 2000)

Mutations conferring drug resistance in malaria parasite drug transporters Pgh1 and PfCRT do not affect steady-state vacuolar Ca2+.

scientific article

Na+/H+ antiporter, chloroquine uptake and drug resistance: inconsistencies in a newly proposed model.

scientific article

New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.

scientific article published on July 1999

Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether

scientific article

Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria

scientific article

OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens

scientific article

P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?

scientific article

Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

scientific article

Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin.

scientific article published on 18 July 2013

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration

scientific article

Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions

scientific article published on 09 June 2008

Pharmacokinetics of Antituberculosis Drugs in HIV-Positive and HIV-Negative Adults in Malawi.

scientific article

Pharmacokinetics of rifampin in Peruvian tuberculosis patients with and without comorbid diabetes or HIV

scientific article

Pharmacokinetics-Pharmacodynamics of High-Dose Ivermectin with Dihydroartemisinin-Piperaquine on Mosquitocidal Activity and QT-prolongation (IVERMAL)

scientific article published on 09 October 2018

Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure

scientific article

Plasmodium falciparum: sacrificing membrane to grow crystals?

scientific article published on 01 January 2003

Population Pharmacokinetic properties of Sulfadoxine and Pyrimethamine: A pooled analysis to Inform Optimal Dosing in African Children with Uncomplicated Malaria

scientific article published on 20 February 2018

Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone

scientific article published in March 2006

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

scientific article published in November 2006

Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Burkina Faso: an open label trial

scientific article published on 07 March 2019

Population pharmacokinetics of sulfadoxine and pyrimethamine in Malawian children with malaria.

scientific article

Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties

scientific article published on 19 October 2018

Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp.

scientific article

Potent enhancement of the sensitivity of Plasmodium falciparum to chloroquine by the bisbenzylisoquinoline alkaloid cepharanthin.

scientific article published on October 2000

Practical HPLC methods for the quantitative determination of common antimalarials in Africa.

scientific article published on 13 November 2006

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

scientific article published on 01 March 2019

Proteomic analysis of cerebrospinal fluid in pneumococcal meningitis reveals potential biomarkers associated with survival.

scientific article published on August 2010

Proteomics analysis of antimalarial targets of Garcinia mangostana Linn.

scientific article

Quantification of rifampicin in human plasma and cerebrospinal fluid by a highly sensitive and rapid liquid chromatographic-tandem mass spectrometric method.

scientific article

Quantitative determination of carbaryl and carbaryl metabolites by reversed-phase high-performance liquid chromatography

scientific article published on 01 February 1987

Rapid and sensitive method for the determination of albendazole and albendazole sulphoxide in biological fluids

scientific article published on 01 May 1991

Rapid chloroquine efflux phenotype in both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. A correlation of chloroquine sensitivity with energy-dependent drug accumulation.

scientific article

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

scientific article published on 12 December 2013

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis

scholarly article

Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin.

scientific article

Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum.

scientific article

Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes

scientific article published on April 2000

Reprint of "Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin".

scientific article published on 20 January 2014

Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro

scientific article published on 02 February 2009

Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.

scientific article published on 27 March 2018

Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection

scientific article published on 01 November 1992

Selective toxicity of dihydroartemisinin on human CD34+ erythroid cell differentiation ⬇️

scientific article published on August 3, 2010

Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.

scientific article published on 8 February 2009

Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum

scientific article

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.

scientific article

Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models

scientific article published on 16 January 2019

Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population is not Related to Anti-retroviral Therapy

scientific article published on 4 February 2017

Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n=3' or 4') against Plasmodium falciparum in in vitro models.

scientific article published on 15 June 2011

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.

scientific article published on October 2013

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria

scientific article published on 17 May 2018

Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology

scientific article published on 15 September 2006

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

scientific article published on April 2009

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

scientific article

Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.

scientific article

The Nobel Prize in Medicine 2015: Two drugs that changed global health

scientific article published in December 2015

The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents.

scientific article

The digestive food vacuole of the malaria parasite is a dynamic intracellular Ca2+ store.

scientific article

The disposition of primaquine in the isolated perfused rat liver. Stereoselective formation of the carboxylic acid metabolite

scientific article published on 01 October 1987

The disposition of pyrimethamine in the isolated perfused rat liver

scientific article

The effect of 2,2'-substitution on the metabolism and toxicity of dapsone in vitro and in vivo.

scientific article published in March 1998

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: A systematic review and pooled analysis of individual patient data

scientific article published on 16 March 2015

The effect of fluorine substitution on the haemotoxicity of Primaquine

scientific article published in October 1995

The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.

scientific article published on April 1994

The effect of malaria infection on antipyrine metabolite formation in the rat.

scientific article published in April 1991

The effect of malaria infection on paracetamol disposition in the rat.

scientific article published in June 1991

The effect of variations in urinary pH on the pharmacokinetics of diethylcarbamazine ⬇️

scientific article published on December 1, 1981

The folate metabolic network of Falciparum malaria.

scientific article published on 27 February 2013

The molecular mechanism of action of artemisinin--the debate continues.

scientific article published on 12 March 2010

The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?

scientific article

The pharmacokinetics of ethynylestradiol in the presence and absence of gestodene and desogestrel

scientific article published on 01 April 1991

The potential of desipramine to reverse chloroquine resistance of Plasmodium falciparum is reduced by its binding to plasma protein

scientific article

The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development

scientific article published on 11 March 2014

The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

scientific article published on September 1996

The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro

scientific article

The safety and kinetics of intramuscular quinine in Malawian children with moderately severe falciparum malaria.

scientific article published in July 1990

The toxicity of artemisinin and related compounds on neuronal and glial cells in culture

scientific article published on 01 June 1995

Therapy of falciparum malaria in sub-saharan Africa: from molecule to policy

scientific article published in July 2004

Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria.

scientific article

Vacuolar acidification and chloroquine sensitivity in Plasmodium falciparum.

scientific article

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