List of works - Jian Yu

A cell-penetrating peptide suppresses inflammation by inhibiting NF-κB signaling

scientific article

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

scientific article published on 01 March 2007

A simplified system for generating recombinant adenoviruses

scientific article

ADAR1 is essential for intestinal homeostasis and stem cell maintenance.

scientific article published on 18 April 2013

An apoptosis-independent role of SMAC in tumor suppression

scientific article published on 2 July 2012

Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway

scientific article published on 23 January 2008

Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells

scientific article

BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade

scientific article published on 06 October 2021

BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.

scientific article

BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

scientific article published on 24 June 2016

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis ⬇️

scientific article published on November 16, 2010

Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress

scientific article published on 21 December 2016

Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.

scientific article published on 26 April 2016

Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens.

scientific article

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.

scientific article published on 11 July 2016

Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.

scientific article

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

scientific article

Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

scientific article

Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

scientific article published on 21 August 2013

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

scientific article

Immunogenic cell death in colon cancer prevention and therapy

scientific article published on 25 March 2020

Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

scientific article published on 30 January 2012

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

scientific article published on 04 October 2016

Interferon b drives intestinal regeneration after radiation

scientific article published on 06 October 2021

Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model.

scientific article

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

scientific article

Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.

scientific article published on 23 April 2015

NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells

scientific article published on January 2008

Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis

scientific article published on 18 February 2021

Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis.

scientific article published on 28 July 2006

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

scientific article

PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.

scientific article

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

scientific article

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

scientific article

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

scientific article

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

scientific article

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

scientific article

PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis

scientific article published on 20 February 2020

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.

scientific article

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

scientific article

Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.

scientific article

Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

scientific article published on 20 February 2006

Role of Smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma.

scientific article published on 15 June 2011

SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events

scientific article

Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway

scientific article

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.

scientific article published on 8 February 2013

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

scientific article published on 21 March 2022

Targeting p53-dependent stem cell loss for intestinal chemoprotection.

scientific article published in February 2018

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

scientific article

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

scientific article published on 14 December 2012

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.

scientific article

eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis

scientific article published on 02 November 2020

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.

scientific article

List of works by Jian Yu

A cell-penetrating peptide suppresses inflammation by inhibiting NF-κB signaling

A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells

A simplified system for generating recombinant adenoviruses

ADAR1 is essential for intestinal homeostasis and stem cell maintenance.

An apoptosis-independent role of SMAC in tumor suppression

Anti-cancer effects of JKA97 are associated with its induction of cell apoptosis via a Bax-dependent and p53-independent pathway

Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells

BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade

BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs.

BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells

Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis ⬇️

Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress

Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.

Early Prediction of Cancer Progression by Depth-Resolved Nanoscale Mapping of Nuclear Architecture from Unstained Tissue Specimens.

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.

Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.

Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1.

Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.

Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

Immunogenic cell death in colon cancer prevention and therapy

Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice

Interferon b drives intestinal regeneration after radiation

Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model.

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice

Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.

NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells

Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis

Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis.

PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells

PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01.

PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

PUMA-mediated epithelial cell apoptosis promotes Helicobacter pylori infection-mediated gastritis

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice.

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.

Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

Role of Smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma.

SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events

Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.

Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer

Targeting p53-dependent stem cell loss for intestinal chemoprotection.

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.

eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis

mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.