Search filters

List of works by Gregory Hannon

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout

scientific article published on July 2017

A CRISPR Resource for Individual, Combinatorial, or Multiplexed Gene Knockout

scientific article published on September 2017

A Happy 3′ Ending to the piRNA Maturation Story

scientific article published on 01 February 2016

A MicroRNA feedback circuit in midbrain dopamine neurons

scientific journal article

A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA Pathway ⬇️

scientific article published on 09 May 2013

A biochemical approach to identifying microRNA targets

scholarly article

A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii

scientific article published on 30 April 2007

A computational algorithm to predict shRNA potency.

scientific article

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

scientific journal article

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

scientific article

A genetic screen for candidate tumor suppressors identifies REST

scientific article

A genome-scale shRNA resource for transgenic RNAi in Drosophila

scientific article

A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in Drosophila

scientific article (publication date: 6 June 2013)

A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis

scientific article (publication date: April 2014)

A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

scientific article

A genomic-scale artificial microRNA library as a tool to investigate the functionally redundant gene space in Arabidopsis.

scientific article

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

scientific article

A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

scientific article

A microRNA component of the p53 tumour suppressor network

scientific article

A microRNA polycistron as a potential human oncogene

scientific article (publication date: 9 June 2005)

A micrococcal nuclease homologue in RNAi effector complexes

scientific article

A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity

scientific article published on 6 May 2010

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

scientific journal article

A pipeline for the generation of shRNA transgenic mice

scientific article published on 02 February 2012

A rapid and scalable system for studying gene function in mice using conditional RNA interference

scientific article published on April 2011

A resource for large-scale RNA-interference-based screens in mammals.

scientific article published in March 2004

A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish.

scientific article

A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells

scientific article

A role for the P-body component GW182 in microRNA function

scientific article

ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation

scientific article

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc

scholarly article

Alta-Cyclic: a self-optimizing base caller for next-generation sequencing

scientific article

An alternative mode of microRNA target recognition

scientific article published on 12 February 2012

An atlas of chromatoid body components

scientific article published on 19 February 2014

An endogenous small interfering RNA pathway in Drosophila

scientific article

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

scientific article published on 03 February 2003

An epigenetic memory of pregnancy in the mouse mammary gland

scientific article published on 7 May 2015

An epigenetic role for maternally inherited piRNAs in transposon silencing

scientific article

An evolutionarily conserved stop codon enrichment at the 5' ends of mammalian piRNAs

scientific article published on 19 April 2022

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

scientific article

An open letter to cancer researchers

scientific article published on 01 October 2005

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

scientific article

Ancestral roles of small RNAs: an Ago-centric perspective

scientific article published on October 2011

Ancient animal microRNAs and the evolution of tissue identity

scientific article

Arginine methylation as a molecular signature of the Piwi small RNA pathway

scientific article

Argonaute2 is the catalytic engine of mammalian RNAi

scientific article (publication date: 3 September 2004)

Astrin regulates Aurora-A localization.

scientific article published on 24 March 2008

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells

scientific article published on 16 May 2017

Biochemical specialization within Arabidopsis RNA silencing pathways

scientific article published in August 2005

COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors

scientific article published on 23 January 2018

Cancer proliferation gene discovery through functional genomics.

scientific article

Canonical and alternate functions of the microRNA biogenesis machinery.

scientific article

Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs

scientific article published on August 2009

Cell-type-based analysis of microRNA profiles in the mouse brain.

scientific article published on January 2012

Characterization of Dicer-deficient murine embryonic stem cells.

scientific article

Cloning of short hairpin RNAs for gene knockdown in mammalian cells.

scientific article

Comparative analysis of argonaute-dependent small RNA pathways in Drosophila

scientific article

Compressed Genotyping

scientific article published on February 1, 2010

Conservation of small RNA pathways in platypus

scientific article

Conserved themes in small-RNA-mediated transposon control

scientific article

Corrigendum: Evolutionary expansion of DNA hypomethylation in the mammalian germline genome.

scientific article

Creating an miR30-based shRNA vector

scientific article published on 01 July 2013

Creating transgenic shRNA mice by recombinase-mediated cassette exchange

scientific article published on September 2013

Critical roles for Dicer in the female germline

scientific article published on March 2007

Crystal structure of Argonaute and its implications for RISC slicer activity

scientific article (publication date: 3 September 2004)

Cyfip1 is a putative invasion suppressor in epithelial cancers

scientific article

Cytoplasmic compartmentalization of the fetal piRNA pathway in mice

scientific journal article

DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysis

scientific article published on 15 May 2009

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

scientific article

De novo DNA demethylation and noncoding transcription define active intergenic regulatory elements.

scientific article published on 28 June 2013

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence

scientific article

Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting

scientific article (publication date: 2 April 2010)

Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles.

scientific article

Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts

scientific article

Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence

scientific article

Design of 240,000 orthogonal 25mer DNA barcode probes

scientific article

Determining the yield and quality of purified RNA.

scientific article

Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor

scientific article published on 15 December 2007

Developmentally regulated piRNA clusters implicate MILI in transposon control

scientific journal article

Dicer is essential for mouse development

scientific journal article

Dicer-2 processes diverse viral RNA species

scientific article

Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment

scientific article

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

scientific article

Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.

scientific article

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila

scientific article

Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation

scientific article published on 24 September 2006

Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases

scientific article

Dnmt2-dependent methylomes lack defined DNA methylation patterns

scientific article published on 2 May 2013

Dogma derailed: the many influences of RNA on the genome

scientific article

Drosophila H1 Regulates the Genetic Activity of Heterochromatin by Recruitment of Su(var)3-9 ⬇️

scientific article published on April 5, 2013

Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano

scientific article

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

scientific article published on 19 June 2020

Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

scientific article published on 8 February 2012

Enrichment of poly(A)+ mRNA using immobilized oligo(dT).

scientific article

Erratum: A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

scholarly article published in Nature Structural & Molecular Biology

Essential Role for endogenous siRNAs during meiosis in mouse oocytes

scientific article

Ethanol precipitation of RNA and the use of carriers.

scientific article published in June 2010

Evolutionary expansion of DNA hypomethylation in the mammalian germline genome

scientific article published on 19 December 2017

Evolutionary flux of canonical microRNAs and mirtrons in Drosophila

scientific article published on January 2010

Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis

scientific article

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length

scientific article

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

scientific journal article

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

scientific article published on March 2011

Fragile X-related protein and VIG associate with the RNA interference machinery

scientific article published on October 2002

Free energy lights the path toward more effective RNAi

scientific article published on 01 December 2003

Functional identification of optimized RNAi triggers using a massively parallel sensor assay

scientific article

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

scientific article

Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci

scientific article

Generation of transgenic Drosophila expressing shRNAs in the miR-1 backbone

scientific article published on May 2014

Genetic interactions of G-quadruplexes in humans

scientific article published on 9 July 2019

Genome analysis of the platypus reveals unique signatures of evolution

scientific article

Genome analysis of the platypus reveals unique signatures of evolution

scientific article published in Nature

Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano.

scientific article

Genome-wide in situ exon capture for selective resequencing

scientific article published on 4 November 2007

Genomic landscape of human allele-specific DNA methylation.

scientific article

Germline transmission of RNAi in mice

scientific article published in February 2003

Guidelines for the use of RNA purification kits.

scientific article published on July 2010

Hierarchical rules for Argonaute loading in Drosophila

scientific article

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing

scientific article published on 06 July 2009

Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing

scientific article

Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas

scientific article published on 9 September 2011

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

scientific article

Inducible, reversible, and stable RNA interference in mammalian cells

scholarly article

Inducing RNAi in C. elegans by feeding with dsRNA-expressing E. coli.

scientific article published in December 2012

Inducing RNAi in Caenorhabditis elegans by Injection of dsRNA

scientific article published on 04 January 2016

Inducing RNAi in Drosophila cells by soaking with dsRNA.

scientific article published on May 2014

Inducing RNAi in Drosophila cells by transfection with dsRNA.

scientific article published on May 2013

Induction and biochemical purification of RNA-induced silencing complex from Drosophila S2 cells

scientific article published on January 2004

Infection of mammalian cells with retroviral shRNAs

scientific article published on August 2013

Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation

scientific article

Lessons from Nature: microRNA-based shRNA libraries

scientific article

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline

scientific journal article

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

scientific article

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

scientific article

MicroRNA100 inhibits self-renewal of breast cancer stem-like cells and breast tumor development

scientific article

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells.

scientific article

MicroRNAs: small RNAs with a big role in gene regulation

scientific article (publication date: July 2004)

Minotaur is critical for primary piRNA biogenesis.

scientific article published on 20 June 2013

Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-Hairpin RNA Library Screening ⬇️

scientific article published on April 11, 2012

Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells.

scientific article published on 11 April 2013

Multiple roles for Piwi in silencing Drosophila transposons.

scientific article published on 7 February 2013

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma

scientific article published on 04 October 2016

Mutations in the RNA granule component TDRD7 cause cataract and glaucoma

scientific article

Nondenaturing agarose gel electrophoresis of RNA.

scientific article published in June 2010

Oncogenic ras and p53 cooperate to induce cellular senescence

scientific article

Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway

scientific article published on July 2016

One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing

scientific article

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

scientific article published in 2022

Packaging shRNA retroviruses

scientific article published on August 2013

Panoramix enforces piRNA-dependent cotranscriptional silencing

scientific article

Patient-derived tumor xenografts: transforming clinical samples into mouse models

scientific article

Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified.

scientific article

Polyacrylamide gel electrophoresis of RNA.

scientific article published in June 2010

Preparation of cytoplasmic and nuclear RNA from tissue culture cells

scientific article

Preparation of small RNA libraries for high-throughput sequencing.

scientific article

Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila

scientific article

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

scientific article

Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform

scientific article published on 27 July 2009

Processing of primary microRNAs by the Microprocessor complex

scientific article (publication date: 11 November 2004)

Production of artificial piRNAs in flies and mice

scientific article published on 17 November 2011

Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis

scientific article published on 18 November 2004

Profiling essential genes in human mammary cells by multiplex RNAi screening

scientific article published on February 2008

Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members

scientific article published on 07 July 2009

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

scientific article

Purification of RNA by SDS solubilization and phenol extraction.

scientific article published in June 2010

Purification of RNA using TRIzol (TRI reagent).

scientific article published in June 2010

Purified Argonaute2 and an siRNA form recombinant human RISC

scientific article (publication date: April 2005)

RNA interference

scientific article (publication date: 11 July 2002)

RNA interference by short hairpin RNAs expressed in vertebrate cells

scientific article published in January 2004

RNA interference in adult mice.

scientific article published in July 2002

RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells

scientific article

RNA interference: a promising approach to antiviral therapy?

scientific article published on 01 November 2002

RNA interference: the new somatic cell genetics?

scientific article

RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age.

scientific article published in November 2004

RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription

retracted paper

RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos

scientific article published on 01 May 2004

RNAi in Cultured Mammalian Cells Using Synthetic siRNAs: Table 1 ⬇️

scientific article published on September 1, 2012

RNAi: an ever-growing puzzle ⬇️

scientific article published on April 1, 2003

RNF17 blocks promiscuous activity of PIWI proteins in mouse testes

scientific article published on 26 June 2015

RNase III enzymes and the initiation of gene silencing

scientific article published on March 2004

Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation

scientific article published on 6 December 2015

Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates

scientific article published on 03 July 2013

Removal of DNA from RNA.

scientific article

Removal of ribosomal subunits (and rRNA) from cytoplasmic extracts before solubilization with SDS and deproteinization

scientific article published in June 2010

Retraction: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription

scientific article published on 01 October 2005

Second-generation shRNA libraries covering the mouse and human genomes

scientific article

Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila

scientific article published on 05 August 2009

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

scientific article (publication date: 15 April 2002)

Short hairpin activated gene silencing in mammalian cells

scientific article published in January 2004

Silencing of microRNA families by seed-targeting tiny LNAs

scientific article published on 20 March 2011

Site identification in high-throughput RNA-protein interaction data

scientific article

Small RNA sorting: matchmaking for Argonautes.

scientific article published on 30 November 2010

Small RNA-based silencing strategies for transposons in the process of invading Drosophila species

scientific article

Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide

scientific article

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary

scientific article

Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates

scientific article

Stable suppression of gene expression by RNAi in mammalian cells

scientific article

Starvation-induced transgenerational inheritance of small RNAs in C. elegans.

scientific article

Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion

scholarly article

Suppression of prion protein in livestock by RNA interference.

scholarly article

Suppression of tumorigenesis by the p53 target PUMA

scientific article

Synthetic shRNAs as potent RNAi triggers

scientific article published on 26 December 2004

Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes

scientific article

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

scientific article

Targeted enrichment of specific regions in the human genome by array hybridization

scientific article

Targeted investigation of the Neandertal genome by array-based sequence capture

scientific article

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

scientific article (publication date: November 2002)

The CRISPR system: small RNA-guided defense in bacteria and archaea

scientific article

The Making of a Slicer: Activation of Human Argonaute-1

scientific article

The Structure of Human Argonaute-2 in Complex with miR-20a

scientific article

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer

scientific article

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation.

scientific article

The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.

scientific article

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

scientific article

The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.

scientific article published on 24 August 2009

The guardian's little helper: microRNAs in the p53 tumor suppressor network

scientific article published on December 2007

The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

scientific article

The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles

scientific journal article

The piRNA pathway in flies: highlights and future directions.

scientific article published on 11 January 2013

The role of piRNAs in mouse spermatogenesis

scientific article published in January 2007

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

scientific article

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy

scientific article published on 4 January 2012

Tissue-specific and reversible RNA interference in transgenic mice

scientific article

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

scientific article

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

scientific article (publication date: 23 June 2008)

Transformation of normal human cells in the absence of telomerase activation.

scientific article

Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.

scientific article

Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil

scientific article

Two waves of de novo methylation during mouse germ cell development.

scientific article

Uncovering RNAi mechanisms in plants: biochemistry enters the foray

scientific article

Unlocking the potential of the human genome with RNA interference

scientific article

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila

scientific article

lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation

lncRNA requirements for mouse acute myeloid leukemia and normal differentiation.

scientific article published on 6 September 2017

lncRNAs in development and disease: from functions to mechanisms

scientific article published on July 2017

miR-19 is a key oncogenic component of mir-17-92

scientific article

miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex

scientific article

microRNAs join the p53 network--another piece in the tumour-suppression puzzle

scientific article

piRNA production requires heterochromatin formation in Drosophila

scientific article

piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis

scientific article published on May 2015

piRNA-guided co-transcriptional silencing coopts nuclear export factors

scientific article published on 20 June 2019

shutdown is a component of the Drosophila piRNA biogenesis machinery.

scientific article

siRNAs and shRNAs: skeleton keys to the human genome.

scientific article

Paulina is supported by:

About Paulina

Help