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List of works by Kristel Van Steen

A Report of the First Biennial Meeting on Capita Selecta in Complex Disease Analysis (CSCDA2010), Leuven, Belgium, August 25-27, 2010

article

A cautionary note on the impact of protocol changes for genome-wide association SNP × SNP interaction studies: an example on ankylosing spondylitis.

scientific article published on 05 May 2015

A comparison of multivariate genome-wide association methods.

scientific article

A different view on fine-scale population structure in Western African populations

scientific article published on 19 October 2019

A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects

scientific article published on 12 August 2004

A family-based association test to detect gene-gene interactions in the presence of linkage.

scientific article

A local influence approach applied to binary data from a psychiatric study

scientific article

A roadmap to multifactor dimensionality reduction methods

scientific article

A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection ⬇️

scientific article published on April 25, 2013

A screening methodology based on Random Forests to improve the detection of gene-gene interactions

scientific article published on 12 May 2010

A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk

scientific article (publication date: 24 January 2017)

Active PAI-1 as marker for venous thromboembolism: Case–control study using a comprehensive panel of PAI-1 and TAFI assays

scientific article published on 20 August 2014

Anti-Tumor Necrosis Factor Therapy Restores Peripheral Blood B-cell Subsets and CD40 Expression in Inflammatory Bowel Diseases

scientific article published on 16 September 2015

Anti-infliximab antibody concentrations can guide treatment intensification in patients with Crohn's disease who lose clinical response.

scientific article

Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood

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Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: a prospective cohort study

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Baseline health-related quality-of-life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer.

scientific article

Behind the (impedance) baseline in children

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Challenges and opportunities in genome-wide environmental interaction (GWEI) studies

scientific article published on 4 July 2012

Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q

scientific article

Comparison of linkage and association strategies for quantitative traits using the COGA dataset

scientific article published on 30 December 2005

Corrigendum to "Genome-wide association interaction analysis for Alzheimer's disease." [Neurobiol. Aging 35 (2014) 2436-2443].

scientific article

Crohnʼs Disease and Month of Birth

scientific article published on 01 June 2005

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis

scientific article published on July 2004

Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?

scientific article published on 18 November 2005

Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts

scientific article

Effects of domperidone on QTc interval in infants

scientific article published on 27 January 2012

Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis

scientific article published on 27 June 2011

Eotaxin polymorphisms and serum total IgE levels in children with asthma

scientific article published on 01 February 2006

Esophageal impedance baseline is age dependent.

scientific article

FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals

scientific article

Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohnʼs disease

article

Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

scientific article published on 6 February 2015

Framework for the Integration of Genomics, Epigenomics and Transcriptomics in Complex Diseases.

scientific article published on 28 July 2015

GENESTAT: an information portal for design and analysis of genetic association studies

scientific article (publication date: April 2009)

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

scientific article published on 03 October 2013

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.

scientific article

Genetic risk profiling and prediction of disease course in Crohn's disease patients

scientific article

Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease.

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Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis

scientific article published on July 2004

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease

scientific article published on 20 November 2015

Genome-wide association interaction analysis for Alzheimer's disease

scientific article

Genomic screening and replication using the same data set in family-based association testing

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Genomic screening in family-based association testing.

scientific article published on 30 December 2005

Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: an international multicenter study

scientific article

Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings.

scientific article published in July 2008

Heterogeneous nuclear RNPs as targets of autoantibodies in systemic rheumatic diseases

scientific article published on 01 January 2012

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

scientific article

High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples reveals significant increases in two bifidobacterial species after inulin-type prebiotic intake.

scientific article published on 6 December 2010

How to increase our belief in discovered statistical interactions via large-scale association studies?

scientific article published on 06 March 2019

Identification of a novel autoantigen in inflammatory bowel disease by protein microarray

scientific article published on 25 October 2010

Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

scientific article published on 20 July 2009

In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma.

scientific article

Integration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer

scientific article

Integration of gene expression and methylation to unravel biological networks in glioblastoma patients.

scientific article published on 26 December 2016

Integrative eQTL analysis of tumor and host omics data in individuals with bladder cancer.

scientific article

Interassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis

scientific article published in August 2004

Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis

scientific article published on 24 December 2010

Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease

scientific article

Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn's Disease

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Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort.

scientific article published on 2 October 2008

Lower-Order Effects Adjustment in Quantitative Traits Model-Based Multifactor Dimensionality Reduction ⬇️

scientific article published on January 5, 2012

Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis

scientific article published on 28 September 2011

Model-Based Multifactor Dimensionality Reduction for Rare Variant Association Analysis

scientific article published on 28 July 2015

Model-Based Multifactor Dimensionality Reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data ⬇️

scientific article published on March 16, 2011

Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise

scientific article

Molecular reclassification of Crohn's disease by cluster analysis of genetic variants

scientific article

Molecular reclassification of Crohn's disease: a cautionary note on population stratification

scientific article (publication date: 2013)

Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment

scientific article

Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment.

scientific article

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis.

scientific article

Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease

scientific article published in September 2009

Neutrophil gelatinase B-associated lipocalin and matrix metalloproteinase-9 complex as a surrogate serum marker of mucosal healing in ulcerative colitis.

scientific article

New serological markers in inflammatory bowel disease are associated with complicated disease behaviour

scientific article

Outcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy

scientific article published on 6 January 2011

PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies.

scientific article published on March 2005

Pancreatic Autoantibodies in Inflammatory Bowel Disease

article

Paternal history of asthma and airway responsiveness in children with asthma

scientific article published on 03 June 2005

Perspectives on genome-wide multi-stage family-based association studies

scientific article published on 17 May 2011

Pit pattern analysis with high-definition chromoendoscopy and narrow-band imaging for optical diagnosis of dysplasia in patients with ulcerative colitis

scientific article published on 3 October 2017

Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit*

article

Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients.

scientific article published on 29 August 2012

Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men.

scientific article

Practical aspects of gene regulatory inference via conditional inference forests from expression data.

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Practical aspects of genome-wide association interaction analysis

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Predictive value of epithelial gene expression profiles for response to infliximab in Crohn's disease.

scientific article published in December 2010

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma

scientific article

Profile of pediatric Crohn's disease in Belgium.

scientific article published on 9 May 2013

Restoration of Foxp3+ Regulatory T-cell Subsets and Foxp3- Type 1 Regulatory-like T Cells in Inflammatory Bowel Diseases During Anti-tumor Necrosis Factor Therapy

scientific article

Risk of malignancies in patients with inflammatory bowel disease treated with thiopurines or anti-TNF alpha antibodies

scientific article published on 30 April 2014

Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.

scientific article

Short-term effect of infliximab is reflected in the clot lysis profile of patients with inflammatory bowel disease: a prospective study

scientific article

Small effect of the androgen receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men.

scientific article published on 21 April 2009

Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma

scientific article published on 26 June 2012

Statistical Analysis of High-Dimensional Genetic Data in Complex Traits.

scientific article

Statistical methods for genome-wide association studies

scientific article published on 01 May 2018

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

scientific article

TNFA -308G>A in two international population-based cohorts and risk of asthma.

scientific article published on 2 April 2008

The AIMe registry for artificial intelligence in biomedical research

scientific article published on 25 August 2021

Tolerability of Shortened Infliximab Infusion Times in Patients With Inflammatory Bowel Diseases: A Single-Center Cohort Study

scientific article published on 15 March 2011

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.

scientific article

Toward the integration of Omics data in epidemiological studies: still a "long and winding road".

scientific article

Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease

scientific article published on 24 February 2015

Unique gene expression and MR T2 relaxometry patterns define chronic murine dextran sodium sulphate colitis as a model for connective tissue changes in human Crohn's disease

scientific article

Withdrawal of immunomodulators after co-treatment does not reduce trough level of infliximab in patients with Crohn's disease.

scientific article published on 25 July 2014

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