List of works - Junichiro Futami

A novel gene expression system strongly enhances the anticancer effects of a REIC/Dkk-3-encoding adenoviral vector.

scientific article published on 31 December 2013

A suitable and effective stepwise oxidative refolding procedure for highly-cationic tetrameric avidin in nucleic acid free conditions

scientific article published on 28 May 2020

A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment

scientific article

Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells.

scientific article

An efficient method for the preparation of preferentially heterodimerized recombinant S100A8/A9 coexpressed in Escherichia coli

scientific article published on 19 March 2016

DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes

scientific article published on 7 July 2014

Denatured and reversibly cationized p53 readily enters cells and simultaneously folds to the functional protein in the cells

scientific article published in May 2006

Denatured mammalian protein mixtures exhibit unusually high solubility in nucleic acid-free pure water

scientific article

Dramatic increase in expression of a transgene by insertion of promoters downstream of the cargo gene.

scientific article published on July 2014

Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide

scientific article published on 11 January 2010

Evaluation of irreversible protein thermal inactivation caused by breakage of disulphide bonds using methanethiosulphonate.

scientific article published on 29 September 2017

Exploiting protein cationization techniques in future drug development.

scientific article published on February 2007

Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene

scientific article

Identification of novel extracellular protein for PCB/biphenyl metabolism in Rhodococcus jostii RHA1.

scientific article published on February 2016

Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression.

scientific article

In vivo protein transduction to the CNS.

scientific article published on 9 March 2006

Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization ⬇️

scientific article published on August 9, 2013

Insertional-fusion of basic fibroblast growth factor endowed ribonuclease 1 with enhanced cytotoxicity by steric blockade of inhibitor interaction.

scientific article

Intracellular delivery of proteins into mammalian living cells by polyethylenimine-cationization.

scientific article published on February 2005

Leucyl/Phenylalanyl-tRNA-protein transferase-mediated chemoenzymatic coupling of N-terminal Arg/Lys units in post-translationally processed proteins with non-natural amino acids

scientific article

MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding

scientific article

Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

scientific article published on 14 December 2018

Nucleotide sequence encoding human pancreatic ribonuclease

scientific article

Polyethylenimine-cationized beta-catenin protein transduction activates the Wnt canonical signaling pathway more effectively than cationic lipid-based transduction.

scientific article published on April 2010

Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups

scientific article (publication date: 26 June 2001)

Protein cationization techniques for artificial control of physical property of protein and their medical applications

scientific article published on 01 January 2013

Protein transduction assisted by polyethylenimine-cationized carrier proteins.

scientific article published on June 2005

Recombinant human pancreatic ribonuclease produced in E. coli: importance of the amino-terminal sequence.

scientific article

Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements

scientific article published on 12 June 2017

S100A11, an dual mediator for growth regulation of human keratinocytes

scientific article published on 31 October 2007

Sensitive Multiplexed Quantitative Analysis of Autoantibodies to Cancer Antigens with Chemically S-Cationized Full-Length and Water-Soluble Denatured Proteins.

scientific article published on 10 September 2015

Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei.

scientific article

The cysteine-rich core domain of REIC/Dkk-3 is critical for its effect on monocyte differentiation and tumor regression.

scientific article

Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution

scientific article

Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans

scientific article published on 01 April 1997

Transient cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen.

scientific article published on January 2008

Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells.

scientific article

Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity

scientific article

exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis

scientific article published on 04 December 2018

ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.

scientific article published on 18 September 2017

‘Crystal lattice engineering,’ an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines

scientific article

List of works by Junichiro Futami

A novel gene expression system strongly enhances the anticancer effects of a REIC/Dkk-3-encoding adenoviral vector.

A suitable and effective stepwise oxidative refolding procedure for highly-cationic tetrameric avidin in nucleic acid free conditions

A vaccine strategy with multiple prostatic acid phosphatase-fused cytokines for prostate cancer treatment

Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells.

An efficient method for the preparation of preferentially heterodimerized recombinant S100A8/A9 coexpressed in Escherichia coli

DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes

Denatured and reversibly cationized p53 readily enters cells and simultaneously folds to the functional protein in the cells

Denatured mammalian protein mixtures exhibit unusually high solubility in nucleic acid-free pure water

Dramatic increase in expression of a transgene by insertion of promoters downstream of the cargo gene.

Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide

Evaluation of irreversible protein thermal inactivation caused by breakage of disulphide bonds using methanethiosulphonate.

Exploiting protein cationization techniques in future drug development.

Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene

Identification of novel extracellular protein for PCB/biphenyl metabolism in Rhodococcus jostii RHA1.

Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression.

In vivo protein transduction to the CNS.

Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization ⬇️

Insertional-fusion of basic fibroblast growth factor endowed ribonuclease 1 with enhanced cytotoxicity by steric blockade of inhibitor interaction.

Intracellular delivery of proteins into mammalian living cells by polyethylenimine-cationization.

Leucyl/Phenylalanyl-tRNA-protein transferase-mediated chemoenzymatic coupling of N-terminal Arg/Lys units in post-translationally processed proteins with non-natural amino acids

MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding

Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis

Nucleotide sequence encoding human pancreatic ribonuclease

Polyethylenimine-cationized beta-catenin protein transduction activates the Wnt canonical signaling pathway more effectively than cationic lipid-based transduction.

Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups

Protein cationization techniques for artificial control of physical property of protein and their medical applications

Protein transduction assisted by polyethylenimine-cationized carrier proteins.

Recombinant human pancreatic ribonuclease produced in E. coli: importance of the amino-terminal sequence.

Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements

S100A11, an dual mediator for growth regulation of human keratinocytes

Sensitive Multiplexed Quantitative Analysis of Autoantibodies to Cancer Antigens with Chemically S-Cationized Full-Length and Water-Soluble Denatured Proteins.

Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei.

The cysteine-rich core domain of REIC/Dkk-3 is critical for its effect on monocyte differentiation and tumor regression.

Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution

Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans

Transient cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen.

Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells.

Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity

exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis

ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.

‘Crystal lattice engineering,’ an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines