List of works - David M. Smith

A Conserved F Box Regulatory Complex Controls Proteasome Activity in Drosophila ⬇️

scientific article published on April 29, 2011

A Practical Review of Proteasome Pharmacology

article

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

scientific article published on 15 March 2018

ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle ⬇️

scientific article published on February 18, 2011

ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.

scientific article

ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function.

scientific article

ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea

scientific article published on 06 June 2007

Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNFα and NOX2 dependent pathway

scientific article

Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice

scientific article published on 16 July 2018

Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing.

scientific article

Could a Common Mechanism of Protein Degradation Impairment Underlie Many Neurodegenerative Diseases?

scientific article published on 19 August 2018

Differential effects of proteasome inhibitors on cell cycle and apoptotic pathways in human YT and Jurkat cells.

scientific article published on January 2006

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry

scientific article

Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial-mesenchymal transition.

scientific article

Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions

scientific article

Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases

scientific article

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

scientific article

Naturally occurring proteasome inhibitors from mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors.

scientific article published on August 2005

Proteasomes and their associated ATPases: a destructive combination

scientific article

The Proteasomal ATPases Use a Slow but Highly Processive Strategy to Unfold Proteins

scientific article

List of works by David M. Smith

A Conserved F Box Regulatory Complex Controls Proteasome Activity in Drosophila ⬇️

A Practical Review of Proteasome Pharmacology

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle ⬇️

ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.

ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function.

ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea

Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNFα and NOX2 dependent pathway

Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice

Conformational switching in the coiled-coil domains of a proteasomal ATPase regulates substrate processing.

Could a Common Mechanism of Protein Degradation Impairment Underlie Many Neurodegenerative Diseases?

Differential effects of proteasome inhibitors on cell cycle and apoptotic pathways in human YT and Jurkat cells.

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry

Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial-mesenchymal transition.

Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions

Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

Naturally occurring proteasome inhibitors from mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors.

Proteasomes and their associated ATPases: a destructive combination

The Proteasomal ATPases Use a Slow but Highly Processive Strategy to Unfold Proteins