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List of works by Natalia Trayanova

"Beauty is a light in the heart": the transformative potential of optogenetics for clinical applications in cardiovascular medicine.

scientific article

A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles

scientific article

A Novel Methodology for Assessing the Bounded-Input Bounded-Output Instability in QT Interval Dynamics: Application to Clinical ECG With Ventricular Tachycardia ⬇️

scientific article published on October 6, 2011

A comprehensive multiscale framework for simulating optogenetics in the heart.

scientific article published on January 2013

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

A computational approach to understanding the cardiac electromechanical activation sequence in the normal and failing heart, with translation to the clinical practice of CRT

scientific article (publication date: 2012)

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms

scientific article

A feasibility study of arrhythmia risk prediction in patients with myocardial infarction and preserved ejection fraction.

scientific article published in December 2016

A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models.

scientific article published on 31 May 2012

Accuracy of prediction of infarct-related arrhythmic circuits from image-based models reconstructed from low and high resolution MRI.

scientific article published on 13 October 2015

Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling

scientific article

Action potential morphology heterogeneity in the atrium and its effect on atrial reentry: a two-dimensional and quasi-three-dimensional study.

scientific article published in June 2006

Advances in modeling ventricular arrhythmias: from mechanisms to the clinic.

scientific article published on 06 December 2013

Arrhythmia dynamics in computational models of the atria following virtual ablation of re-entrant drivers

scientific article published on 01 November 2018

Arrhythmia risk stratification based on QT interval instability: an intracardiac electrocardiogram study.

scientific article published on 13 February 2013

Association of regional myocardial conduction velocity with the distribution of hypoattenuation on contrast-enhanced perfusion computed tomography in patients with postinfarct ventricular tachycardia

scientific article published on 26 October 2018

Atrial defibrillation voltage: falling to a new low ⬇️

scientific article published on October 29, 2010

Automatically generated, anatomically accurate meshes for cardiac electrophysiology problems.

scientific article

Cardiac Optogenetics: 2018

scientific article published on 01 February 2018

Cardiac electromechanical models: from cell to organ.

scientific article published on 11 August 2011

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.

scientific article

Characterization of the relationship between preshock state and virtual electrode polarization-induced propagated graded responses resulting in arrhythmia induction.

scientific article

Comparative analysis of three different modalities for characterization of the seismocardiogram.

scientific article published on January 2009

Comparing Reentrant Drivers Predicted by Image-Based Computational Modeling and Mapped by Electrocardiographic Imaging in Persistent Atrial Fibrillation

scientific article

Comparison of the effects of continuous and pulsatile left ventricular-assist devices on ventricular unloading using a cardiac electromechanics model.

scientific article published on 11 November 2011

Computational Identification of Ventricular Arrhythmia Risk in Pediatric Myocarditis

scientific article published on 06 March 2019

Computational analysis of the effect of mitral and aortic regurgitation on the function of ventricular assist devices using 3D cardiac electromechanical model.

scientific article published on 28 October 2017

Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model.

scientific article published on 3 February 2015

Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones

scientific article

Computational medicine: translating models to clinical care

scientific article

Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations

scientific article

Computational models in cardiology

scientific article published on 01 February 2019

Computational models of heart disease.

scientific article published on January 2014

Computational prediction of the effects of the intra-aortic balloon pump on heart failure with valvular regurgitation using a 3D cardiac electromechanical model

scientific article published on 23 October 2017

Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.

scientific article published on 19 June 2016

Computationally guided personalized targeted ablation of persistent atrial fibrillation

scientific article published on 19 August 2019

Correction: Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling.

scientific article published on 19 May 2016

Defibrillation of the heart: insights into mechanisms from modelling studies.

scientific article

Defibrillation success with high frequency electric fields is related to degree and location of conduction block.

scientific article published on 23 January 2013

Disrupted calcium release as a mechanism for atrial alternans associated with human atrial fibrillation

scientific article

Distribution of electromechanical delay in the heart: insights from a three-dimensional electromechanical model.

scientific article

EFFECT OF KCNQ1 G229D MUTATION ON CARDIAC PUMPING EFFICACY AND REENTRANT DYNAMICS IN VENTRICLES: COMPUTATIONAL STUDY.

scientific article published on 27 February 2018

Early somatic mosaicism is a rare cause of long-QT syndrome

scientific article published on 28 September 2016

Effects of mechano-electric feedback on scroll wave stability in human ventricular fibrillation

scientific article

Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis.

scientific article published on January 2014

Efficient preloading of the ventricles by a properly timed atrial contraction underlies stroke work improvement in the acute response to cardiac resynchronization therapy

scientific article published on 06 August 2013

Electromechanical models of the ventricles

scientific article

Estimation of local orientations in fibrous structures with applications to the Purkinje system.

scientific article

Evaluating intramural virtual electrodes in the myocardial wedge preparation: simulations of experimental conditions.

scientific article

Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach

scientific article

Field of view of mapping catheters quantified by electrogram associations with radius of myocardial attenuation on contrast-enhanced cardiac computed tomography

scientific article published on 02 June 2018

From genetics to smart watches: developments in precision cardiology

scientific article published on 01 February 2019

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

scientific article

How computer simulations of the human heart can improve anti-arrhythmia therapy

scientific article published in December 2015

How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post-infarction patients

scientific article published on 09 January 2020

Image-based Reconstruction of 3D Myocardial Infarct Geometry for Patient Specific Applications.

scientific article published in February 2015

Image-based estimation of ventricular fiber orientations for patient-specific simulations.

scientific article published on January 2011

Image-based estimation of ventricular fiber orientations for personalized modeling of cardiac electrophysiology.

scientific article

Image-based left ventricular shape analysis for sudden cardiac death risk stratification

scientific article

Image-based models of cardiac structure in health and disease.

scientific article

Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies.

scientific article published on 31 January 2009

Image-based reconstruction of three-dimensional myocardial infarct geometry for patient-specific modeling of cardiac electrophysiology

scientific article published in August 2015

Imaging-Based Simulations for Predicting Sudden Death and Guiding Ventricular Tachycardia Ablation

scientific article

In the Spotlight: Cardiovascular Engineering

scientific article published on 01 January 2008

In the spotlight: Cardiovascular engineering

scientific article published on 19 November 2012

In the spotlight: cardiovascular engineering

scientific article published on 01 January 2011

In the spotlight: cardiovascular engineering.

scientific article published in January 2010

Increased thin filament activation enhances alternans in human chronic atrial fibrillation

scientific article published on 24 August 2018

Influence of LVAD function on mechanical unloading and electromechanical delay: a simulation study

scientific article published on 3 November 2017

Initiation of a High-Frequency Jet Ventilation Strategy for Catheter Ablation for Atrial Fibrillation: Safety and Outcomes Data

scientific article published on 01 November 2018

Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart.

scientific article published on January 2009

Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation.

scientific article

Light-based Approaches to Cardiac Arrhythmia Research: From Basic Science to Translational Applications

scientific article

Maintenance of ventricular fibrillation in heterogeneous ventricle

scientific article published on 01 January 2006

Mapping of cardiac electrical activation with electromechanical wave imaging: an in silico-in vivo reciprocity study.

scientific article

Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management

scientific article

Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium.

scientific article published on October 2008

Mechanisms Underlying Isovolumic Contraction and Ejection Peaks in Seismocardiogram Morphology.

scientific article

Mechanisms linking electrical alternans and clinical ventricular arrhythmia in human heart failure.

scientific article

Mechanisms of arrhythmogenesis related to calcium-driven alternans in a model of human atrial fibrillation.

scientific article

Mechanisms of human atrial fibrillation initiation: clinical and computational studies of repolarization restitution and activation latency.

scientific article published on October 2012

Mechanisms of mechanically induced spontaneous arrhythmias in acute regional ischemia.

scientific article

Mechanistic Inquiry into the Role of Tissue Remodeling in Fibrotic Lesions in Human Atrial Fibrillation ⬇️

scientific article published on June 18, 2013

Mechanistic enquiry into the effect of increased pacing rate on the upper limit of vulnerability.

scientific article published in June 2006

Mechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study

scientific article published on 09 August 2013

Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A.

scientific article published on November 2007

Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology.

scientific article

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.

scientific article

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Modeling the aging heart: from local respiratory defects to global rhythm disturbances.

scientific article

Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms

scientific article published on December 2016

Models of cardiac electromechanics based on individual hearts imaging data: image-based electromechanical models of the heart

scientific article

Models of stretch-activated ventricular arrhythmias.

scientific article published on 17 July 2010

Modulation of shock-end virtual electrode polarisation as a direct result of 3D fluorescent photon scattering.

scientific article published in January 2006

Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention

scientific article published on 2 May 2016

Myocardial Infarct Segmentation From Magnetic Resonance Images for Personalized Modeling of Cardiac Electrophysiology

scientific article published on 25 December 2015

Myocardial infarct segmentation and reconstruction from 2D late-gadolinium enhanced magnetic resonance images

scientific article published on 01 January 2014

Myocardial ischemia lowers precordial thump efficacy: an inquiry into mechanisms using three-dimensional simulations.

scientific article published in February 2006

Myofiber Architecture of the Human Atria as Revealed by Submillimeter Diffusion Tensor Imaging.

scientific article published on April 2016

Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy

scientific article

New insights into defibrillation of the heart from realistic simulation studies.

scientific article

New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation

scientific article published on 22 January 2019

Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study.

scientific article published on 4 March 2016

Optimal contrast-enhanced MRI image thresholding for accurate prediction of ventricular tachycardia using ex-vivo high resolution models

scientific article published on 03 October 2018

Optimizing cardiac resynchronization therapy to minimize ATP consumption heterogeneity throughout the left ventricle: a simulation analysis using a canine heart failure model.

scientific article

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.

scientific article

Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability.

scientific article

Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach.

scientific article published on November 2014

Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern

scientific article published on 7 April 2016

Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia

scientific article published on 03 September 2018

Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heart

scientific article published on November 2007

Placement of implantable cardioverter-defibrillators in paediatric and congenital heart defect patients: a pipeline for model generation and simulation prediction of optimal configurations.

scientific article published on 24 June 2013

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.

scientific article published on 24 July 2017

Precisely parameterized experimental and computational models of tissue organization

scientific article published on 29 January 2016

Quantifying the uncertainty in model parameters using Gaussian process-based Markov chain Monte Carlo in cardiac electrophysiology

scientific article published on 17 May 2018

Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study.

scientific article published on 24 December 2015

Reentry in survived subepicardium coupled to depolarized and inexcitable midmyocardium: insights into arrhythmogenesis in ischemia phase 1B

scientific article

Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts.

scientific article published on 10 August 2011

Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation

scientific article

Reversible cardiac conduction block and defibrillation with high-frequency electric field.

scientific article published on September 2011

Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models

scientific article published on 01 June 2018

Role of cellular uncoupling in arrhythmogenesis in ischemia phase 1B.

scientific article published in January 2006

See the light: can optogenetics restore healthy heartbeats? And, if it can, is it really worth the effort?

scientific article published on 02 December 2013

Sensitivity of reentrant driver localization to electrophysiological parameter variability in image-based computational models of persistent atrial fibrillation sustained by a fibrotic substrate.

scientific article

Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles

scientific article

Spatially Adaptive Multi-Scale Optimization for Local Parameter Estimation in Cardiac Electrophysiology

scientific article published on 25 April 2017

Submillimeter diffusion tensor imaging and late gadolinium enhancement cardiovascular magnetic resonance of chronic myocardial infarction

scientific article published on 11 January 2017

Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density.

scientific article

Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.

scientific article

Tachycardia in post-infarction hearts: insights from 3D image-based ventricular models.

scientific article

Terminating ventricular tachyarrhythmias using far-field low-voltage stimuli: mechanisms and delivery protocols

scientific article published on 27 April 2013

Termination of re-entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models

scientific article

The Fibrotic Substrate in Persistent Atrial Fibrillation Patients: Comparison Between Predictions From Computational Modeling and Measurements From Focal Impulse and Rotor Mapping

scientific article published on 29 August 2018

The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation.

scientific article published on 15 December 2011

The role of mechanoelectric feedback in vulnerability to electric shock.

scientific article published on 16 February 2008

The role of personalized atrial modeling in understanding atrial fibrillation mechanisms and improving treatment

scientific article published on 31 January 2019

Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone.

scientific article published on 14 May 2012

Towards personalized computational modelling of the fibrotic substrate for atrial arrhythmia.

scientific article published on December 2016

Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability

scientific article published on 01 January 2006

Tropomyosin dynamics during cardiac muscle contraction as governed by a multi-well energy landscape

scientific article published on 23 August 2018

Tunnel propagation of postshock activations as a hypothesis for fibrillation induction and isoelectric window.

scientific article

Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes.

scientific article published on 17 April 2019

Unstable QT interval dynamics precedes ventricular tachycardia onset in patients with acute myocardial infarction: a novel approach to detect instability in QT interval dynamics from clinical ECG.

scientific article published on 14 August 2011

Using personalized computer models to custom-tailor ablation procedures for atrial fibrillation patients: are we there yet?

scientific article published on 11 April 2017

Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour ⬇️

scientific article published in December 2015

Virtual 3D heart models to aid pacemaker implantation in children.

scientific article published on January 2014

Virtual electrophysiological study as a tool for evaluating efficacy of MRI techniques in predicting adverse arrhythmic events in ischemic patients

scientific article

Virtual electrophysiological study of atrial fibrillation in fibrotic remodeling

scientific article

Vulnerability to electric shocks in the regionally-ischemic ventricles

article

β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle

scientific article

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