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List of works by Tuomas Mirtti

A randomized trial of early detection of clinically significant prostate cancer (ProScreen): study design and rationale

scientific article

Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer.

scientific article published in January 2010

Androgen receptor-interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions

scientific article

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

scientific article

Clonal heterogeneity influences drug responsiveness in renal cancer assessed by ex vivo drug testing of multiple patient-derived cancer cells

scientific article published on 04 November 2018

Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer

scientific article

Cost-effective survival prediction for patients with advanced prostate cancer using clinical trial and real-world hospital registry datasets

scientific article published on 17 November 2019

Cumulative Cancer Locations is a Novel Metric for Predicting Active Surveillance Outcomes: A Multicenter Study

scientific article published on 15 May 2018

Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay.

scientific article published on May 2011

Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression

scientific article

Does patient age affect survival after radical cystectomy?

scientific article published on 02 May 2012

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

scientific article

Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors

scientific article published on 23 September 2019

Expression of cystatins, high molecular weight cytokeratin, and proliferation markers in prostatic adenocarcinoma and hyperplasia.

scientific article published on March 2003

Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology: Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues.

scientific article published on 3 October 2017

Fibroblast as a critical stromal cell type determining prognosis in prostate cancer

scientific article published on 03 July 2019

High-throughput transcriptomic and RNAi analysis identifies AIM1, ERGIC1, TMED3 and TPX2 as potential drug targets in prostate cancer

scientific article

ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer

scientific article

Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer

scientific article published on 4 October 2017

Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy

scientific article published on 27 July 2018

Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy.

scientific article

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

scientific article published on 31 December 2014

Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy

scientific article

Loss of PTEN expression in ERG-negative prostate cancer predicts secondary therapies and leads to shorter disease-specific survival time after radical prostatectomy

scientific article published on 26 August 2016

Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes

scientific article published on 23 August 2017

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

scientific article published on 15 October 2018

N-terminal truncation of Stat5a/b circumvents PIAS3-mediated transcriptional inhibition of Stat5 in prostate cancer cells.

scientific article published on 18 September 2010

New prostate cancer grade grouping system predicts survival after radical prostatectomy

scientific article published on 12 February 2018

Outcome of surgery for patients with renal cell carcinoma and tumour thrombus in the era of modern targeted therapy

scientific article published on October 2016

PTEN Loss but Not ERG Expression in Diagnostic Biopsies Is Associated with Increased Risk of Progression and Adverse Surgical Findings in Men with Prostate Cancer on Active Surveillance

scientific article

PTEN and ERG expression in MRI-ultrasound guided fusion biopsy correlated with radical prostatectomy findings in men with prostate cancer

scientific article published on 07 July 2020

Patient Experience of Systematic Versus Fusion Prostate Biopsies

scientific article published on 15 May 2018

Performance of transrectal prostate biopsies in detecting tumours and implications for focal therapy

scientific article published on 16 July 2014

Pharmacologic suppression of JAK1/2 by JAK1/2 inhibitor AZD1480 potently inhibits IL-6-induced experimental prostate cancer metastases formation

scientific article published on 27 February 2014

Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer

scientific article published on 10 July 2019

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

scientific article

Rac1 nucleocytoplasmic shuttling drives nuclear shape changes and tumor invasion

scientific article published on 29 January 2015

Re: Fatemeh Seyednasrollah, Mehrad Mahmoudian, Liisa Rautakorpi, et al. How Reliable are Trial-based Prognostic Models in Real-world Patients with Metastatic Castration-resistant Prostate Cancer? Eur Urol. 2017;71:838-40.

scientific article

Regulation of prostate cell collagen receptors by malignant transformation.

scientific article

Repeat multiparametric MRI in prostate cancer patients on active surveillance

scientific article published on 27 December 2017

SPCG-15: a prospective randomized study comparing primary radical prostatectomy and primary radiotherapy plus androgen deprivation therapy for locally advanced prostate cancer

scientific article published on 01 October 2018

Sex differences in bladder cancer outcomes among smokers with advanced bladder cancer.

scientific article

Spectral decoupling for training transferable neural networks in medical imaging

scientific article published on 17 January 2022

Stat3 promotes metastatic progression of prostate cancer.

scientific article published on 15 May 2008

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

scientific article published on 18 May 2010

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion

scientific article published on 28 November 2011

T and NK cell abundance defines two distinct subgroups of renal cell carcinoma

scientific article published on 04 January 2022

Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas.

scientific article published on 16 February 2008

Tumor expression of human chorionic gonadotropin beta mRNA and prognosis of prostate cancer treated by radical prostatectomy

scientific article published on 11 July 2019

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition

scientific article published on 22 May 2020

Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer

scientific article published on 21 July 2015

Twenty-year experience of radical cystectomy for bladder cancer in a medium-volume centre.

scientific article published in January 2009

Upper urinary tract and urethral recurrences following radical cystectomy: review of risk factors and outcomes between centres with different follow-up protocols ⬇️

scientific article published on July 19, 2012

Upstaging of urothelial cancer at the time of radical cystectomy: factors associated with upstaging and its effect on outcome.

scientific article published on 9 February 2012

Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: A prospective multi-institutional trial

scientific article published on 03 June 2019

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