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List of works by Karl Bacos

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

scientific article

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes

scientific article published on 11 January 2007

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

scientific article

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

scientific article published on 01 September 2020

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

scientific article

Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

scientific article

Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets

scientific article

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

scientific article published on 16 August 2019

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

scientific article published on 29 October 2016

Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact

scientific article

Increased metabolism in the R6/2 mouse model of Huntington's disease.

scientific article

Islet beta-cell area and hormone expression are unaltered in Huntington's disease

scientific article published on 8 February 2008

Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

scientific article

MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation

scientific article published on 07 August 2018

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion

scientific article

Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

scientific article

Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets

scientific article

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis

scientific article published on 13 January 2005

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

scientific article published on 25 November 2017

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

scientific article published on 21 September 2009

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.

scientific article

Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis

scientific article

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