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List of works by Mark T Orr

'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection

scientific article published on 28 February 2010

A dual TLR agonist adjuvant enhances the immunogenicity and protective efficacy of the tuberculosis vaccine antigen ID93.

scientific article published on 03 January 2014

A structure-function approach to optimizing TLR4 ligands for human vaccines

scientific article (publication date: November 2016)

AS03 stresses out macrophages: Commentary on ‘Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties’.

scientific article

Adjuvant composition and delivery route shape immune response quality and protective efficacy of a recombinant vaccine for Entamoeba histolytica.

scientific article published on 5 June 2018

Adjuvant formulation structure and composition are critical for the development of an effective vaccine against tuberculosis

scientific article published on 09 August 2013

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

scientific article published on 12 November 2016

Antigen presentation by B cells guides programing of memory CD4+ T-cell responses to a TLR4-agonist containing vaccine in mice

scientific article published on 4 October 2016

Assessment of Antigen-Specific Cellular Immunogenicity Using Intracellular Cytokine Staining, ELISpot, and Culture Supernatants

scientific article published on January 2017

CD8 T cell control of HSV reactivation from latency is abrogated by viral inhibition of MHC class I

scientific article

CD94 is essential for NK cell-mediated resistance to a lethal viral disease

scientific article published on April 2011

Cutting edge: recombinant Listeria monocytogenes expressing a single immune-dominant peptide confers protective immunity to herpes simplex virus-1 infection

scientific article published on April 2007

Development and function of CD94-deficient natural killer cells

scientific article

Development of a thermostable nanoemulsion adjuvanted vaccine against tuberculosis using a design-of-experiments approach.

scientific article

Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses

article

Elimination of the cold-chain dependence of a nanoemulsion adjuvanted vaccine against tuberculosis by lyophilization

scientific article published on 29 December 2013

Enhanced Anti-Mycobacterium tuberculosis Immunity over Time with Combined Drug and Immunotherapy Treatment.

scientific article published on 24 May 2018

Enzymatic Conversion of Sucrose to Hydrogen

article

Enzymatic production of biohydrogen

scientific article published in Nature

From mouse to man: safety, immunogenicity and efficacy of a candidate leishmaniasis vaccine LEISH-F3+GLA-SE.

scientific article published on 10 April 2015

IL-18 and Subcapsular Lymph Node Macrophages are Essential for Enhanced B Cell Responses with TLR4 Agonist Adjuvants.

scientific article

Immune subdominant antigens as vaccine candidates against Mycobacterium tuberculosis

scientific article

Inhibition of MHC class I is a virulence factor in herpes simplex virus infection of mice

scientific article

Inhibitory Ly49 receptors on mouse natural killer cells

scientific article published on January 2011

Interferon γ and Tumor Necrosis Factor Are Not Essential Parameters of CD4+ T-Cell Responses for Vaccine Control of Tuberculosis

scientific article

Key roles of adjuvants in modern vaccines

scientific article published on 05 December 2013

Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

scientific article published on 30 March 2009

Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC

scientific article

Mucosal delivery switches the response to an adjuvanted tuberculosis vaccine from systemic TH1 to tissue-resident TH17 responses without impacting the protective efficacy

scientific article

MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

scientific article published on 03 July 2013

Natural killer cell education and tolerance

scientific article published on September 2010

Natural killer cell licensing during viral infection

scientific article published on January 2011

Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus

scientific article

Physicochemical structure of a polyacrylic acid stabilized nanoparticle alum (nanoalum) adjuvant governs TH1 differentiation of CD4+ T cells

scientific article published on 13 January 2020

Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells

scientific article published on 31 July 2013

Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology

scholarly article by Mark T Orr et al published 2019 in npj Vaccines

Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-γ.

scientific article published on 3 December 2014

T cell receptor revision does not solely target recent thymic emigrants

scientific article published in July 2003

The ID93 tuberculosis vaccine candidate does not induce sensitivity to purified protein derivative

scientific article

The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction

scientific article published on 5 January 2016

The TLR4 agonist adjuvant SLA-SE promotes functional mucosal antibodies against a parenterally delivered ETEC vaccine

scientific article published on 28 May 2019

The science of vaccine adjuvants: advances in TLR4 ligand adjuvants

scientific article published on 5 July 2016

Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment

scientific article published on 13 August 2012

Vaccination Produces CD4 T Cells with a Novel CD154-CD40-Dependent Cytolytic Mechanism

scientific article

Vaccine Adjuvants a

αv Integrins regulate germinal center B cell responses through noncanonical autophagy

article

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