List of works - Fredrik Almqvist

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis

scientific article

A Novel Heterocyclic Scaffold Formed by Ring Expansion of a Cyclic Sulfone to Sulfonamides

scientific article published on 01 December 2009

A selective intramolecular 5-exo-dig or 6-endo-dig cyclization en route to 2-furanone or 2-pyrone containing tricyclic scaffolds

scientific article published on 31 October 2011

A three-component reaction forming naphthyridones--synthesis of lophocladine analogs

scientific article published on September 2011

A total synthesis of hydroxylysine in protected form and investigations of the reductive opening of p-methoxybenzylidene acetals

scientific article published in December 2004

Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili

scientific article (publication date: March 2015)

An Improved Procedure for the Synthesis of Enaminones - Dimer Building Blocks in β-Strand Mimetics

An Improved Procedure for the Synthesis of Enaminones — Dimer Building Blocks in β-Strand Mimetics

An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones

scientific article

An improved synthesis of 3-[3-(trifluoromethyl)-3 H -1,2-diazirin-3-yl]aniline: A key intermediate in the synthesis of photoaffinity probes

Asymmetric synthesis of 2,4,5-trisubstituted Δ2-thiazolines

scientific article published on 17 June 2013

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.

scientific article published on March 2016

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

scientific article published on 14 October 2015

C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli.

scientific article

Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli

scientific article published on 7 May 2008

ChemInform Abstract: A Novel Heterocyclic Scaffold Formed by Ring Expansion of a Cyclic Sulfone to Sulfonamides

ChemInform Abstract: Asymmetric Synthesis of 2,4,5-Trisubstituted Δ2-Thiazolines

ChemInform Abstract: Regioselective Halogenations and Subsequent Suzuki-Miyaura Coupling onto Bicyclic 2-Pyridones

ChemInform Abstract: Synthesis of a Novel Tricyclic Peptidomimetic Scaffold

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

scientific article published on 06 May 2019

Complete Regioselective Addition of Grignard Reagents to PyrazineN-Oxides, Toward an Efficient Enantioselective Synthesis of Substituted Piperazines

article

Corrigendum: Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth

scientific article published on 28 October 2015

Cycloaddition of Δ2-Thiazolines and Acyl Ketenes under Acidic Conditions Results in Bicyclic 1,3-Oxazinones and Not 6-Acylpenams as Earlier Reported

scientific article published on 01 March 2005

Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity

scientific article

Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria

scientific article

Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms

scientific article published on 16 March 2012

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

scientific article published on 15 July 2014

Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones—Targeting virulence of uropathogenic E. coli

article by Veronica Berg et al published 15 November 2006 in Bioorganic & Medicinal Chemistry

Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents

scientific article published on 18 June 2012

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth

scientific article published on 28 May 2015

Diverse Functionalization of Thiazolo Ring-Fused 2-Pyridones

scientific article published on 01 June 2007

Diverse Functionalization of Thiazolo Ring-Fused 2-Pyridones

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease

scientific article published on September 2017

Efficient Solution-Phase Parallel Synthesis of 4-Substituted N-Protected Piperidines

Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via delta2-thiazolines

scientific article published in January 2003

Efficient regioselective synthesis of enantiomerically pure 4-hydroxymethyl-Δ2-thiazoline

Efficient, mild and completely regioselective synthesis of substituted pyridines

scientific article published on 16 March 2010

Enantioselective Synthesis of Substituted Piperidines by Addition of Aryl Grignard Reagents to Pyridine N-Oxides

article

Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication

scientific article published on 27 February 2015

Functionalization of bicyclic 2-pyridones targeting pilus biogenesis in uropathogenic Escherichia coli

Hierarchical PLS Modeling for Predicting the Binding of a Comprehensive Set of Structurally Diverse Protein—Ligand Complexes

Hierarchical PLS Modeling for Predicting the Binding of a Comprehensive Set of Structurally Diverse Protein−Ligand Complexes

scientific article published on 01 May 2006

Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections?

scientific article published on 12 January 2012

Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin

scientific article published on 30 October 2017

Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria.

scientific article published on 28 January 2014

Locations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside GM1Micelles

scientific article published on 06 January 2011

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study

scientific article published on 04 February 2012

Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation

scientific article published on 9 February 2012

Microwave-Assisted Synthesis of Highly Substituted Aminomethylated 2-Pyridones

Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Abeta-peptide aggregation inhibitors

scientific article published on 29 June 2005

Microwave-assisted synthesis of highly substituted aminomethylated 2-pyridones

scientific article published in November 2004

Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones

scientific article

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: Templation and inhibition involve oligomers with different structure

scholarly article by Istvan Horvath published in April 2013

Multivariate design and evaluation of a set of RGRPQ-derived innate immunity peptides

scientific article published on 4 April 2006

Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli

scientific article

NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.

scientific article

Optically active bicyclo[2.2.2]octane derivatives; Synthesis of (1S,4R,6R)-6-hydroxybicyclo[2.2.2]octan-2-one from its enantiomer

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system.

scientific article published on 09 May 2016

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens

scientific article

Physical properties of biopolymers assessed by optical tweezers: analysis of folding and refolding of bacterial pili

scientific article published on February 2008

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli

scientific article

Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod.

scientific article published on 19 January 2007

Pilicides — Small Molecules Targeting Bacterial Virulence

Pilicides-small molecules targeting bacterial virulence.

scientific article published on 20 April 2007

Promiscuous cross-seeding between bacterial amyloids promotes interspecies biofilms

scientific article

Pyridine-Fused 2-Pyridones via Povarov and A3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

scientific article published on 20 March 2019

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

scholarly article

Reaction of Pyridine N-Oxides with Grignard Reagents: A Stereodefined Synthesis of Substituted Dienal Oximes

Reactions between Grignard reagents and heterocyclic N-oxides: stereoselective synthesis of substituted pyridines, piperidines, and piperazines

scientific article published on 15 November 2010

Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines

scientific article published on 28 November 2016

Regioselective halogenations and subsequent Suzuki-Miyaura coupling onto bicyclic 2-pyridones

scientific article

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development

scientific article published on 08 March 2019

Selective synthesis of 2-substituted pyridine N-oxides via directed ortho-metallation using Grignard reagents

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

scientific article

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

scientific article

Spirobicyclo[2.2.2]octane Derivatives: Mimetics of Baccatin III and Paclitaxel (Taxol)

Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol).

scientific article published on 4 October 2004

Stereoselective Synthesis of Optically Active β-Lactams, Potential Inhibitors of Pilus Assembly in Pathogenic Bacteria

article by Hans Emtenäs et al published 13 July 2000 in Organic Letters

Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria

scientific article published in April 2003

Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.

scientific article published on 05 December 2016

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity

scientific article

Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity

scientific article

Synthesis and evaluation of dihydroimidazolo and dihydrooxazolo ring-fused 2-pyridones—targeting pilus biogenesis in uropathogenic bacteria

Synthesis of 2-Substituted Pyridines via a Regiospecific Alkylation, Alkynylation, and Arylation of Pyridine N-Oxides

Synthesis of 2-Substituted Pyridines via a Regiospecific Alkylation, Alkynylation, and Arylation of PyridineN-Oxides

scientific article published on 01 March 2007

Synthesis of Fluorescent Ring-Fused 2-Pyridone Peptidomimetics

scientific article published on 14 November 2013

Synthesis of Multi Ring-Fused 2-Pyridones via an Acyl-Ketene Imine Cyclocondensation

scientific article published on 01 March 2006

Synthesis of Multi-Ring-Fused 2-Pyridones via an Acyl-Ketene Imine Cyclocondensation

Synthesis of Multiring Fused 2-Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α-Synuclein Amyloid Formation

scientific article published in 2015

Synthesis of a Novel Tricyclic Peptidomimetic Scaffold

scientific article published on 15 August 2008

Synthesis of substituted 4-pyridones and 4-aminopyridinium salts via a one-pot pyridine synthesis

Targeting virulence for antimicrobial chemotherapy

scientific article published on October 2003

The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation

scientific article published on 7 June 2012

The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.

scientific article

The regio- and stereoselective synthesis of trans-2,3-dihydropyridine N-oxides and piperidines

scientific article

Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

scientific article published on 05 February 2016

Thiazolino 2-Pyridone Amide Isosteres As Inhibitors of Chlamydia trachomatis Infectivity.

scientific article

Unusual light spectroscopic properties of a 2-pyridone-based multi-ring-fused fluorescent scaffold

scientific article published on 20 May 2010

Use of 19F NMR spectroscopy to screen chemical libraries for ligands that bind to proteins

scientific article

List of works by Fredrik Almqvist

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis

A Novel Heterocyclic Scaffold Formed by Ring Expansion of a Cyclic Sulfone to Sulfonamides

A selective intramolecular 5-exo-dig or 6-endo-dig cyclization en route to 2-furanone or 2-pyrone containing tricyclic scaffolds

A three-component reaction forming naphthyridones--synthesis of lophocladine analogs

A total synthesis of hydroxylysine in protected form and investigations of the reductive opening of p-methoxybenzylidene acetals

Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili

An Improved Procedure for the Synthesis of Enaminones - Dimer Building Blocks in β-Strand Mimetics

An Improved Procedure for the Synthesis of Enaminones — Dimer Building Blocks in β-Strand Mimetics

An enantioselective ketene-imine cycloaddition method for synthesis of substituted ring-fused 2-pyridinones

An improved synthesis of 3-[3-(trifluoromethyl)-3 H -1,2-diazirin-3-yl]aniline: A key intermediate in the synthesis of photoaffinity probes

Asymmetric synthesis of 2,4,5-trisubstituted Δ2-thiazolines

Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.

Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts

C-Terminal properties are important for ring-fused 2-pyridones that interfere with the chaperone function in uropathogenic E. coli.

Carboxylic acid isosteres improve the activity of ring-fused 2-pyridones that inhibit pilus biogenesis in E. coli

ChemInform Abstract: A Novel Heterocyclic Scaffold Formed by Ring Expansion of a Cyclic Sulfone to Sulfonamides

ChemInform Abstract: Asymmetric Synthesis of 2,4,5-Trisubstituted Δ2-Thiazolines

ChemInform Abstract: Regioselective Halogenations and Subsequent Suzuki-Miyaura Coupling onto Bicyclic 2-Pyridones

ChemInform Abstract: Synthesis of a Novel Tricyclic Peptidomimetic Scaffold

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis

Complete Regioselective Addition of Grignard Reagents to PyrazineN-Oxides, Toward an Efficient Enantioselective Synthesis of Substituted Piperazines

Corrigendum: Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth

Cycloaddition of Δ2-Thiazolines and Acyl Ketenes under Acidic Conditions Results in Bicyclic 1,3-Oxazinones and Not 6-Acylpenams as Earlier Reported

Design and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence Activity

Design and parallel solid-phase synthesis of ring-fused 2-pyridinones that target pilus biogenesis in pathogenic bacteria

Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones—Targeting virulence of uropathogenic E. coli

Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents

Direct Correlation Between Ligand-Induced α-Synuclein Oligomers and Amyloid-like Fibril Growth

Diverse Functionalization of Thiazolo Ring-Fused 2-Pyridones

Diverse Functionalization of Thiazolo Ring-Fused 2-Pyridones

Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson's disease

Efficient Solution-Phase Parallel Synthesis of 4-Substituted N-Protected Piperidines

Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via delta2-thiazolines

Efficient regioselective synthesis of enantiomerically pure 4-hydroxymethyl-Δ2-thiazoline

Efficient, mild and completely regioselective synthesis of substituted pyridines

Enantioselective Synthesis of Substituted Piperidines by Addition of Aryl Grignard Reagents to Pyridine N-Oxides

Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication

Functionalization of bicyclic 2-pyridones targeting pilus biogenesis in uropathogenic Escherichia coli

Hierarchical PLS Modeling for Predicting the Binding of a Comprehensive Set of Structurally Diverse Protein—Ligand Complexes

Hierarchical PLS Modeling for Predicting the Binding of a Comprehensive Set of Structurally Diverse Protein−Ligand Complexes

Impairment of the biomechanical compliance of P pili: a novel means of inhibiting uropathogenic bacterial infections?

Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin

Isolation and characterization of anti-adenoviral secondary metabolites from marine actinobacteria.

Locations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside GM1Micelles

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study

Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation

Microwave-Assisted Synthesis of Highly Substituted Aminomethylated 2-Pyridones

Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of Abeta-peptide aggregation inhibitors

Microwave-assisted synthesis of highly substituted aminomethylated 2-pyridones

Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: Templation and inhibition involve oligomers with different structure

Multivariate design and evaluation of a set of RGRPQ-derived innate immunity peptides

Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli

NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.

Optically active bicyclo[2.2.2]octane derivatives; Synthesis of (1S,4R,6R)-6-hydroxybicyclo[2.2.2]octan-2-one from its enantiomer

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system.

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens

Physical properties of biopolymers assessed by optical tweezers: analysis of folding and refolding of bacterial pili

Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli

Pilicides regulate pili expression in E. coli without affecting the functional properties of the pilus rod.

Pilicides — Small Molecules Targeting Bacterial Virulence

Pilicides-small molecules targeting bacterial virulence.

Promiscuous cross-seeding between bacterial amyloids promotes interspecies biofilms

Pyridine-Fused 2-Pyridones via Povarov and A3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.

Reaction of Pyridine N-Oxides with Grignard Reagents: A Stereodefined Synthesis of Substituted Dienal Oximes

Reactions between Grignard reagents and heterocyclic N-oxides: stereoselective synthesis of substituted pyridines, piperidines, and piperazines

Regio- and Stereoselective Alkylation of Pyridine-N-oxides: Synthesis of Substituted Piperidines and Pyridines

Regioselective halogenations and subsequent Suzuki-Miyaura coupling onto bicyclic 2-pyridones

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development

Selective synthesis of 2-substituted pyridine N-oxides via directed ortho-metallation using Grignard reagents

Single injection of small-molecule amyloid accelerator results in cell death of nigral dopamine neurons in mice

Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation

Spirobicyclo[2.2.2]octane Derivatives: Mimetics of Baccatin III and Paclitaxel (Taxol)

Spirobicyclo[2.2.2]octane derivatives: mimetics of baccatin III and paclitaxel (Taxol).

Stereoselective Synthesis of Optically Active β-Lactams, Potential Inhibitors of Pilus Assembly in Pathogenic Bacteria

Stereoselective synthesis of optically active bicyclic beta-lactam carboxylic acids that target pilus biogenesis in pathogenic bacteria