List of works - Steven Hahn

A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

scientific article

A transcription reinitiation intermediate that is stabilized by activator

scientific article published in Nature

A yeast TFIIB-related factor involved in RNA polymerase III transcription

scientific article

A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable

scientific article published on April 1988

Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation

scientific article

An ATP-dependent inhibitor of TBP binding to DNA

scientific article published on 01 May 1993

An integrated chemical cross-linking and mass spectrometry approach to study protein complex architecture and function

scientific article

An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression ⬇️

scientific article published on August 1, 1984

Architecture of Protein and DNA Contacts within the TFIIIB-DNA Complex ⬇️

scientific article published on March 1, 1998

Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH

scientific article

Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening ⬇️

scientific article published on July 1, 2012

Architecture of the Saccharomyces cerevisiae RNA polymerase I Core Factor complex.

scientific article published on 17 August 2014

Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex

scientific article published on 12 September 2014

Architecture of the Yeast RNA Polymerase II Open Complex and Regulation of Activity by TFIIF ⬇️

scientific article published on October 24, 2011

Binding of TFIIB to RNA polymerase II: Mapping the binding site for the TFIIB zinc ribbon domain within the preinitiation complex

scientific article published on 01 August 2003

Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.

scholarly article

Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.

scientific article published on 13 December 2010

Dominant negative mutations in yeast TFIID define a bipartite DNA-binding region

scientific article published on 01 April 1991

Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation

scientific article

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae

scientific article published on December 1985

Ellis Englesberg and the discovery of positive control in gene regulation

scientific article

Function of Conserved Topological Regions within the Saccharomyces cerevisiae Basal Transcription Factor TFIIH

scientific article

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

scientific article published in March 2018

In vivo regulation of the Escherichia coli araC promoter.

scientific article

Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB.

scientific article

Isolation of two genes that encode subunits of the yeast transcription factor IIA

scientific article published on February 28, 1992

Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC.

scientific article published in October 2004

Mechanistic Differences in Transcription Initiation at TATA-Less and TATA-Containing Promoters

scientific article published on 16 October 2017

Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters.

scientific article published on 20 October 2016

Model for binding of transcription factor TFIIB to the TBP-DNA complex

scientific article published in Nature

Molecular analysis of the SNF2/SWI2 protein family member MOT1, an ATP-driven enzyme that dissociates TATA-binding protein from DNA

scientific article

Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism.

scientific article

Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.

scientific article published on 27 May 2014

Phase Separation, Protein Disorder, and Enhancer Function

scientific article published on 01 December 2018

Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.

scientific article published on 06 July 2009

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

scientific article published on 11 September 2017

Site-specific cross-linking of TBP in vivo and in vitro reveals a direct functional interaction with the SAGA subunit Spt3.

scientific article published in November 2008

Structural biology: Snapshots of transcription initiation

scientific article published on 11 May 2016

Structural insights into transcription initiation by RNA polymerase II.

scientific article

Structure of human TFIID and mechanism of TBP loading onto promoter DNA

scientific article

Structure(?) and function of acidic transcription activators.

scientific article

TFIIB-related factors in RNA polymerase I transcription

scientific article

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning

scientific article

TFIIIC determines RNA polymerase III specificity at the TATA-containing yeast U6 promoter.

scientific article published on April 1995

Targets of the Gal4 transcription activator in functional transcription complexes.

scientific article

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

scientific article

The Yin and the Yang of mammalian transcription

scientific article published on 01 March 1992

The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex.

scientific article published on 15 July 2007

The role of TAFs in RNA polymerase II transcription

scientific article published on 01 November 1998

The yeast general transcription factor TFIIA is composed of two polypeptide subunits.

scientific article published on October 1991

The zinc ribbon domains of the general transcription factors TFIIB and Brf: conserved functional surfaces but different roles in transcription initiation.

scientific article

Transcription Start Site Scanning and the Requirement for ATP during Transcription Initiation by RNA Polymerase II

scientific article published on 17 April 2016

Transcription activation domains of the yeast factors Met4 and Ino2: tandem activation domains with properties similar to the yeast Gcn4 activator.

scientific article published on 5 March 2018

Transcription of Escherichia coli ara in vitro. The cyclic AMP receptor protein requirement for PBAD induction that depends on the presence and orientation of the araO2 site.

scientific article

Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID.

scientific article published on 13 September 2017

Transcription: basal factors and activation.

scientific article published on April 1996

Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators.

scientific article published on November 2011

Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA

scientific article published on 08 January 2020

Upstream repression and CRP stimulation of the Escherichia coli L-arabinose operon

scientific article published on 01 November 1984

Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences.

scientific article

List of works by Steven Hahn

A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

A transcription reinitiation intermediate that is stabilized by activator

A yeast TFIIB-related factor involved in RNA polymerase III transcription

A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable

Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation

An ATP-dependent inhibitor of TBP binding to DNA

An integrated chemical cross-linking and mass spectrometry approach to study protein complex architecture and function

An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression ⬇️

Architecture of Protein and DNA Contacts within the TFIIIB-DNA Complex ⬇️

Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH

Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening ⬇️

Architecture of the Saccharomyces cerevisiae RNA polymerase I Core Factor complex.

Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex

Architecture of the Yeast RNA Polymerase II Open Complex and Regulation of Activity by TFIIF ⬇️

Binding of TFIIB to RNA polymerase II: Mapping the binding site for the TFIIB zinc ribbon domain within the preinitiation complex

Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.

Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.

Dominant negative mutations in yeast TFIID define a bipartite DNA-binding region

Double-stranded DNA translocase activity of transcription factor TFIIH and the mechanism of RNA polymerase II open complex formation

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae

Ellis Englesberg and the discovery of positive control in gene regulation

Function of Conserved Topological Regions within the Saccharomyces cerevisiae Basal Transcription Factor TFIIH

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

In vivo regulation of the Escherichia coli araC promoter.

Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB.

Isolation of two genes that encode subunits of the yeast transcription factor IIA

Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC.

Mechanistic Differences in Transcription Initiation at TATA-Less and TATA-Containing Promoters

Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters.

Model for binding of transcription factor TFIIB to the TBP-DNA complex

Molecular analysis of the SNF2/SWI2 protein family member MOT1, an ATP-driven enzyme that dissociates TATA-binding protein from DNA

Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism.

Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.

Phase Separation, Protein Disorder, and Enhancer Function

Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.

SAGA Is a General Cofactor for RNA Polymerase II Transcription.

Site-specific cross-linking of TBP in vivo and in vitro reveals a direct functional interaction with the SAGA subunit Spt3.

Structural biology: Snapshots of transcription initiation

Structural insights into transcription initiation by RNA polymerase II.

Structure of human TFIID and mechanism of TBP loading onto promoter DNA

Structure(?) and function of acidic transcription activators.

TFIIB-related factors in RNA polymerase I transcription

TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning

TFIIIC determines RNA polymerase III specificity at the TATA-containing yeast U6 promoter.

Targets of the Gal4 transcription activator in functional transcription complexes.

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

The Yin and the Yang of mammalian transcription

The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex.

The role of TAFs in RNA polymerase II transcription

The yeast general transcription factor TFIIA is composed of two polypeptide subunits.

The zinc ribbon domains of the general transcription factors TFIIB and Brf: conserved functional surfaces but different roles in transcription initiation.

Transcription Start Site Scanning and the Requirement for ATP during Transcription Initiation by RNA Polymerase II

Transcription activation domains of the yeast factors Met4 and Ino2: tandem activation domains with properties similar to the yeast Gcn4 activator.

Transcription of Escherichia coli ara in vitro. The cyclic AMP receptor protein requirement for PBAD induction that depends on the presence and orientation of the araO2 site.

Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID.

Transcription: basal factors and activation.

Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators.

Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA

Upstream repression and CRP stimulation of the Escherichia coli L-arabinose operon

Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences.