List of works - Jeremy P Blaydes

A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture.

scientific article published on December 2010

A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells

scientific article published on 01 August 2013

A novel role for C-terminal binding proteins in the regulation of mitotic fidelity in breast cancer cells.

scientific article published on 13 May 2008

A potential motor neurone-specific monoclonal antibody (MN-1)

scientific article published on 01 August 1991

Activation of p53 protein function in response to cellular irradiation.

scientific article

C-terminal binding proteins play a critical nuclear function in the mitotic fidelity of breast cancer cells.

scientific article published on 18 May 2010

C-terminal binding proteins: emerging roles in cell survival and tumorigenesis.

scientific article

Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma

scientific article

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

CtBPs promote cell survival through the maintenance of mitotic fidelity.

scientific article

CtBPs promote mitotic fidelity through their activities in the cell nucleus.

scientific article published on 8 November 2010

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

scientific article published on 01 August 1998

Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation

scientific article published on 01 November 1999

Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3.

scientific article published on 29 November 2007

Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids

scientific article

Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

scientific article published on November 1996

Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance

scientific article

GC-selective DNA-binding antibiotic, mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis.

scientific article published on 27 February 2006

Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs

scientific article published on 14 March 2019

Glycolysis, via NADH-dependent dimerisation of CtBPs, regulates hypoxia-induced expression of CAIX and stem-like breast cancer cell survival

scientific article published on 03 July 2020

HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.

scientific article published on 20 July 2010

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma

scientific article published on 17 January 2019

Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines

scientific article published on April 2006

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers

scientific article published on 24 March 2006

Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.

scientific article published in January 1995

Loss of C-terminal binding protein transcriptional corepressor leads to aberrant mitosis and cell death in breast cancer cells.

scientific article published in November 2006

Loss of responsiveness to transforming growth factor beta (TGFbeta) is tightly linked to tumorigenicity in a model of thyroid tumour progression

scientific article published on 01 February 1996

MNK1 and EIF4E are downstream effectors of MEKs in the regulation of the nuclear export of HDM2 mRNA.

scientific article published on 10 September 2007

Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1

scientific article published on 01 June 1995

Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.

scientific article published on 20 December 2016

Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins

scientific article

Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism

scientific article

Stem cell-like breast cancer cells with acquired resistance to metformin are sensitive to inhibitors of NADH-dependent CtBP dimerization

scientific article published on 01 July 2019

Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression

scientific article published on January 1, 1992

Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways

scientific article published on 01 August 2000

Synthesis and evaluation of a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-trans-Pro in poly-L-proline type II helix conformation.

scientific article published in April 2015

Targeting Tumour Proliferation with a Small‐Molecule Inhibitor of AICAR Transformylase Homodimerization ⬇️

scientific article published on July 4, 2012

The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ

scientific article

The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells.

scientific article

The influence of cell context on the selection pressure for p53 mutation in human cancer.

scientific article published on January 1998

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

scientific article published in June 1998

The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival

scientific article

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

scientific article published on April 1997

Transcription of click-linked DNA in human cells.

scientific article published on 22 January 2014

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

scientific article published on 05 May 2020

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

scientific article published in May 2003

List of works by Jeremy P Blaydes

A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture.

A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells

A novel role for C-terminal binding proteins in the regulation of mitotic fidelity in breast cancer cells.

A potential motor neurone-specific monoclonal antibody (MN-1)

Activation of p53 protein function in response to cellular irradiation.

C-terminal binding proteins play a critical nuclear function in the mitotic fidelity of breast cancer cells.

C-terminal binding proteins: emerging roles in cell survival and tumorigenesis.

Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

CtBPs promote cell survival through the maintenance of mitotic fidelity.

CtBPs promote mitotic fidelity through their activities in the cell nucleus.

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

Dephosphorylation of p53 at Ser20 after cellular exposure to low levels of non-ionizing radiation

Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3.

Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids

Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance

GC-selective DNA-binding antibiotic, mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis.

Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs

Glycolysis, via NADH-dependent dimerisation of CtBPs, regulates hypoxia-induced expression of CAIX and stem-like breast cancer cell survival

HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma

Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers

Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.

Loss of C-terminal binding protein transcriptional corepressor leads to aberrant mitosis and cell death in breast cancer cells.

Loss of responsiveness to transforming growth factor beta (TGFbeta) is tightly linked to tumorigenicity in a model of thyroid tumour progression

MNK1 and EIF4E are downstream effectors of MEKs in the regulation of the nuclear export of HDM2 mRNA.

Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1

Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.

Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins

Senescence induction in renal carcinoma cells by Nutlin-3: a potential therapeutic strategy based on MDM2 antagonism

Stem cell-like breast cancer cells with acquired resistance to metformin are sensitive to inhibitors of NADH-dependent CtBP dimerization

Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression

Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways

Synthesis and evaluation of a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-trans-Pro in poly-L-proline type II helix conformation.

Targeting Tumour Proliferation with a Small‐Molecule Inhibitor of AICAR Transformylase Homodimerization ⬇️

The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ

The effects of restricted glycolysis on stem-cell like characteristics of breast cancer cells.

The influence of cell context on the selection pressure for p53 mutation in human cancer.

The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2.

The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

Transcription of click-linked DNA in human cells.

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.