List of works - Deborah Young

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

scientific article

VEGF links hippocampal activity with neurogenesis, learning and memory

scientific journal article

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

scientific article

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

scientific article published in October 1997

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats

scientific article published on February 2005

Long-term follow-up after gene therapy for canavan disease.

scientific article

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates.

scientific article

An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy

scientific article published on 01 February 2000

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.

scientific article published in September 2001

Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms

scientific article published in January 1994

AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease

scientific article

AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease

scientific article published on May 2004

Neuronal death and survival in two models of hypoxic-ischemic brain damage

scientific article published on 01 April 1999

Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

scientific article published on October 2003

Peroral gene therapy of lactose intolerance using an adeno-associated virus vector

scientific article published on October 1, 1998

Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus.

scientific article

Trk receptor alterations in Alzheimer's disease.

scientific article

Development and optimization of adeno-associated virus vector transfer into the central nervous system

scientific article

Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats

scholarly article

Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.

scientific article published on 9 June 2007

Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.

scientific article

c-Jun promotes neurite outgrowth and survival in PC12 cells

scientific article published on 01 November 2000

Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.

scientific article

Identification and distribution of aspartoacylase in the postnatal rat brain

scientific article published on October 6, 2003

A novel role of circadian transcription factor DBP in hippocampal plasticity.

scientific article published on 27 October 2005

Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice

scientific article published in April 2006

Differential expression of inducible transcription factors in basal ganglia neurons.

scientific article

Clusterin accumulates in dying neurons following status epilepticus

scientific article published on 01 September 1995

Do c-Jun, c-Fos, and amyloid precursor protein play a role in neuronal death or survival?

scientific article published on August 1, 1998

CCAAT-enhancer binding protein alpha is expressed in activated microglial cells after brain injury.

scientific article published in October 1998

Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge.

scientific article published in January 1998

Knockdown and overexpression of NR1 modulates NMDA receptor function.

scientific article

Induction of clusterin in the immature brain following a hypoxic-ischemic injury

scientific article published on 01 July 1996

Gene regulation systems for gene therapy applications in the central nervous system.

scientific article published on 05 January 2012

Neuronal injury following electrically induced status epilepticus with and without adenosine receptor antagonism

scientific article published on 01 June 1995

HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity

scientific article published on 8 April 2008

Comparison of the blood-brain barrier and liver penetration of acridine antitumor drugs.

scientific article published in January 1992

Blood-brain barrier penetration of felbamate

scientific article published in September 1992

Pharmacokinetics and toxicity of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide after i.v. administration in the mouse.

scientific article published in January 1992

Non-NMDA glutamate receptors are involved in the maintenance of status epilepticus

scientific article published on 01 October 1993

MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus.

scientific article published in March 1993

Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size

scientific article published on 30 May 2013

Phosphorylation-dependent degradation of transgenic CREB protein initiated by heterodimerization

scientific article published on 13 December 2006

Disposition of amsacrine and its analogue 9-([2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921) in plasma, liver, and Lewis lung tumors in mice

scientific article published on 01 February 1990

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

scientific article

AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.

scientific article

Pharmacokinetics of acridine-4-carboxamide in the rat, with extrapolation to humans.

scientific article published in January 1993

Nucleic Acid-Based Therapy Approaches for Huntington's Disease

scientific article published on 11 January 2012

Blood-brain glucose transfer in the mouse.

scientific article published on 01 May 1993

Intraperitoneal administration of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in the mouse: bioavailability, pharmacokinetics and toxicity after a single dose

scientific article published in January 1992

List of works by Deborah Young

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

VEGF links hippocampal activity with neurogenesis, learning and memory

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats

Long-term follow-up after gene therapy for canavan disease.

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates.

An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.

Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms

AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease

AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease

Neuronal death and survival in two models of hypoxic-ischemic brain damage

Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

Peroral gene therapy of lactose intolerance using an adeno-associated virus vector

Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus.

Trk receptor alterations in Alzheimer's disease.

Development and optimization of adeno-associated virus vector transfer into the central nervous system

Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats

Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.

Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.

c-Jun promotes neurite outgrowth and survival in PC12 cells

Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.

Identification and distribution of aspartoacylase in the postnatal rat brain

A novel role of circadian transcription factor DBP in hippocampal plasticity.

Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice

Differential expression of inducible transcription factors in basal ganglia neurons.

Clusterin accumulates in dying neurons following status epilepticus

Do c-Jun, c-Fos, and amyloid precursor protein play a role in neuronal death or survival?

CCAAT-enhancer binding protein alpha is expressed in activated microglial cells after brain injury.

Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge.

Knockdown and overexpression of NR1 modulates NMDA receptor function.

Induction of clusterin in the immature brain following a hypoxic-ischemic injury

Gene regulation systems for gene therapy applications in the central nervous system.

Neuronal injury following electrically induced status epilepticus with and without adenosine receptor antagonism

HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity

Comparison of the blood-brain barrier and liver penetration of acridine antitumor drugs.

Blood-brain barrier penetration of felbamate

Pharmacokinetics and toxicity of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide after i.v. administration in the mouse.

Non-NMDA glutamate receptors are involved in the maintenance of status epilepticus

MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus.

Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size

Phosphorylation-dependent degradation of transgenic CREB protein initiated by heterodimerization

Disposition of amsacrine and its analogue 9-([2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921) in plasma, liver, and Lewis lung tumors in mice

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.

Pharmacokinetics of acridine-4-carboxamide in the rat, with extrapolation to humans.

Nucleic Acid-Based Therapy Approaches for Huntington's Disease

Blood-brain glucose transfer in the mouse.

Intraperitoneal administration of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in the mouse: bioavailability, pharmacokinetics and toxicity after a single dose