List of works - Jesper B Birk

5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes.

scientific article

A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action

scientific article published on 23 January 2020

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

scientific article published on 5 August 2009

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice

scientific article published on 21 January 2015

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

scientific article published on 29 September 2015

AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans

scientific article

Absence of humoral mediated 5'AMP-activated protein kinase activation in human skeletal muscle and adipose tissue during exercise.

scientific article published on 25 October 2007

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle

scientific article published on 18 November 2013

Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation

scientific article published on 15 January 2013

Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training ⬇️

scientific article published on 12 January 2021

Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action.

scientific article published on 29 May 2010

Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus

scientific article published on 16 October 2009

Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle.

scientific article published on 23 April 2013

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

scientific article published on 5 May 2005

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

scientific article published on 26 October 2016

Epinephrine-stimulated glycogen breakdown activates glycogen synthase and increases insulin-stimulated glucose uptake in epitrochlearis muscles.

scientific article published on 2 December 2014

Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4.

scientific article

Exercise signalling to glucose transport in skeletal muscle

scientific article published in May 2004

Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity

scientific article published on 11 July 2012

Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle

scientific article published on 13 September 2010

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

scientific article published on 25 July 2018

Genetic and metabolic effects on skeletal muscle AMPK in young and older twins

scientific article published on 11 August 2009

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

scientific journal article

Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.

scientific article published on 4 August 2009

Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects

scientific article published in September 2017

Human muscle fiber type-specific insulin signaling: impact of obesity and type 2 diabetes

scientific article published on 03 September 2014

Human muscle fibre type-specific regulation of AMPK and downstream targets by exercise.

scientific article published on 27 February 2015

Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes.

scientific article published on 10 February 2012

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

scientific article

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

scientific article published on 31 October 2007

Insulin signalling: effects of prior exercise.

scientific article

Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise.

scientific article

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

scientific article published on 21 October 2003

Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling

scientific article

Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle

scientific article

Oral glucose ingestion attenuates exercise-induced activation of 5′-AMP-activated protein kinase in human skeletal muscle

scientific article published on 01 April 2006

PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion.

scientific article

Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene

scientific article published on 08 June 2006

Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle

scientific article published on 12 October 2006

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

scientific article

Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle

scientific article published on 3 February 2009

Regulation of PDH in human arm and leg muscles at rest and during intense exercise.

scientific article

Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation

scientific article published on March 2004

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

scientific article published in December 2004

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle

scientific article published on 23 January 2016

Transgenic models--a scientific tool to understand exercise-induced metabolism: the regulatory role of AMPK (5'-AMP-activated protein kinase) in glucose transport and glycogen synthase activity in skeletal muscle.

scientific article published on December 2003

List of works by Jesper B Birk

5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes.

A Single Bout of One-Legged Exercise to Local Exhaustion Decreases Insulin Action in Nonexercised Muscle Leading to Decreased Whole-Body Insulin Action

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

AMPKα is critical for enhancing skeletal muscle fatty acid utilization during in vivo exercise in mice

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans

Absence of humoral mediated 5'AMP-activated protein kinase activation in human skeletal muscle and adipose tissue during exercise.

Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle

Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation

Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training ⬇️

Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action.

Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus

Effect of birth weight and 12 weeks of exercise training on exercise-induced AMPK signaling in human skeletal muscle.

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Epinephrine-stimulated glycogen breakdown activates glycogen synthase and increases insulin-stimulated glucose uptake in epitrochlearis muscles.

Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4.

Exercise signalling to glucose transport in skeletal muscle

Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity

Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

Genetic and metabolic effects on skeletal muscle AMPK in young and older twins

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice.

Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects

Human muscle fiber type-specific insulin signaling: impact of obesity and type 2 diabetes

Human muscle fibre type-specific regulation of AMPK and downstream targets by exercise.

Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes.

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Insulin signalling: effects of prior exercise.

Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise.

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling

Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle

Oral glucose ingestion attenuates exercise-induced activation of 5′-AMP-activated protein kinase in human skeletal muscle

PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion.

Partial rescue of in vivo insulin signalling in skeletal muscle by impaired insulin clearance in heterozygous carriers of a mutation in the insulin receptor gene

Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle

Regulation of PDH in human arm and leg muscles at rest and during intense exercise.

Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation

The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading.

The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle

Transgenic models--a scientific tool to understand exercise-induced metabolism: the regulatory role of AMPK (5'-AMP-activated protein kinase) in glucose transport and glycogen synthase activity in skeletal muscle.