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List of works by Silvia Dei

4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.

scientific article

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

scientific article published on 01 December 2020

Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity

scientific article

Carbachol dimers as homobivalent modulators of muscarinic receptors

scientific article

Design of novel nicotinic ligands through 3D database searching

scientific article published in February 2005

Design, Synthesis, and Preliminary Pharmacological Evaluation of New Quinoline Derivatives as Nicotinic Ligands

scientific article published on 12 September 2007

Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current.

scientific article published in February 2005

Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring

scientific article published on 31 May 2013

Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers.

scientific article

Design, synthesis, and in vitro activity of catamphiphilic reverters of multidrug resistance: discovery of a selective, highly efficacious chemosensitizer with potency in the nanomolar range

scientific article published on 01 May 1999

Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers

scientific article published on September 2010

Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain

scientific article

Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins

scientific article

Dialkylaminoalkyl esters of 2,2-diphenyl-2-alkylthioacetic acids: a new class of potent and functionally selective muscarinic antagonists.

scientific article published in October 1994

Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators.

scientific article published in February 2005

Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding

scientific article published on 7 January 2008

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells

scientific article published on 10 April 2020

Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent

scientific article

Energy resolved tandem mass spectrometry experiments for resolution of isobaric compounds: a case of cis/trans isomerism.

scientific article published in January 2016

Exploratory chemistry toward the identification of a new class of multidrug resistance reverters inspired by pervilleine and verapamil models.

scientific article published in November 2005

Further structure-activity relationships in the series of tropanyl esters endowed with potent antinociceptive activity.

scientific article published in December 1998

Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist

scientific article published in March 2006

Hybridized and isosteric analogues of N1-acetyl-N4-dimethyl-piperazinium iodide (ADMP) and N1-phenyl-N4-dimethyl-piperazinium iodide (DMPP) with central nicotinic action.

scientific article published in March 1999

IN VITRO CHARACTERIZATION OF A NOVEL, POTENT AND SELECTIVE M3 ANTAGONIST

scientific article published on 01 January 1997

In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug resistance-reverting agents

scientific article published on 28 June 2016

Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs

scientific article published on 25 January 2012

Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: Further restriction of molecular flexibility maintains high potency and efficacy ⬇️

scientific article published on November 20, 2010

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

scientific article published on 22 April 2020

Isomeric N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent P-glycoprotein (Pgp)-dependent multidrug resistance (MDR) inhibitors.

scientific article published on 26 January 2007

Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity.

scientific article published in December 2004

Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity.

scientific article

Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters.

scientific article published on 30 September 2014

Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives

scientific article published on 11 April 2008

N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent transporter-dependent multidrug resistance inhibitors

scientific article published in February 2009

N,N-bis(cyclohexanol)amine aryl esters: the discovery of a new class of highly potent inhibitors of transporter-dependent multidrug resistance (MDR).

scientific article published on January 2010

N-alkanol-N-cyclohexanol amine aryl esters: Multidrug resistance (MDR) reversing agents with high potency and efficacy

scientific article published on 13 January 2017

New quinoline derivatives as nicotinic receptor modulators.

scientific article published on 19 January 2016

New structure–activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR) ⬇️

scientific article published on November 24, 2012

Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents

scientific article published on 16 February 2017

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters.

scientific article published on May 1994

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters

scientific article published on 01 May 1994

Reduced flexibility analogs of analgesic and cognition enhancing alpha-tropanyl esters

scientific article published on 01 February 1996

Reversal of multidrug resistance by verapamil analogues.

scientific article published on August 1995

SAR studies on the potent and selective muscarinic antagonist 2-ethylthio-2,2-diphenylacetic acid N,N-diethylaminoethyl ester.

scientific article published in May 1997

Structural dependence of the allosteric interaction of semi-rigid verapamil analogues with dihydropyridine-binding in kitten heart.

scientific article published on November 1995

Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers.

scientific article published in June 2017

Structure-activity relationships and optimisation of the selective MDR modulator 2-(3,4-dimethoxyphenyl)-5-(9-fluorenylamino)-2-(methylethyl) pentanenitrile and its N-methyl derivative.

scientific article

Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.

scientific article published in May 2001

Structure-activity relationships studies in a series of N,N-bis(alkanol)amine aryl esters as P-glycoprotein (Pgp) dependent multidrug resistance (MDR) inhibitors.

scientific article published in February 2010

Structure−Affinity Relationships of a Unique Nicotinic Ligand: N-Dimethyl-N4-phenylpiperazinium Iodide (DMPP) ⬇️

scientific article published on November 8, 2001

Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.

scientific article

Synthesis and Biological Evaluation of 3,7-Diazabicyclo[4.3.0]nonan-8-ones as Potential Nootropic and Analgesic Drugs

scientific article published on 07 March 2011

Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine1

scientific article published on 01 December 2020

Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates

scientific article

Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure

scientific article

Synthesis, characterization and pharmacological profile of tropicamide enantiomers

scientific article published on 01 January 1996

The power of energy-resolved tandem mass spectrometry experiments for resolution of isomers: the case of drug plasma stability investigation of multidrug resistance inhibitors

scientific article published in February 2016

Verapamil analogues with restricted molecular flexibility: synthesis and pharmacological evaluation of the four isomers of alpha-[1-[3-[N-[1- [2-(3,4-dimethoxyphenyl)ethyl]]-N-methylamino]cyclohexyl]]-alpha- isopropyl-3,4-dimethoxybenzene-acetonitri

scientific article published in February 1993

[35S]GTP gamma S binding studies of amphiphilic drugs-activated Gi proteins: a caveat

scientific article published on 28 February 2009

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