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List of works by Alon Chen

A Methyl-Balanced Diet Prevents CRF-Induced Prenatal Stress-Triggered Predisposition to Binge Eating-like Phenotype.

scientific article

A paradigm shift in translational psychiatry through rodent neuroethology

scientific article published in 2023

A second isoform of gonadotropin-releasing hormone is present in the brain of human and rodents.

scientific article published in September 1998

A soluble mouse brain splice variant of type 2alpha corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity

scientific article

A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery ⬇️

scientific article published on October 11, 2010

ACTH-Dependent Regulation of MicroRNA As Endogenous Modulators of Glucocorticoid Receptor Expression in the Adrenal Gland

Adipose tissue foam cells are present in human obesity

scientific article published on 31 January 2013

Altered Brain-Derived Neurotrophic Factor Expression in the Ventral Tegmental Area, but not in the Hippocampus, Is Essential for Antidepressant-Like Effects of Electroconvulsive Therapy ⬇️

scientific article published on August 17, 2012

Amelioration of brain pathology and behavioral dysfunction in mice with lupus following treatment with a tolerogenic peptide.

scientific article published in December 2009

Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress

scientific article published on November 2016

An anxiolytic role for CRF receptor type 1 in the globus pallidus.

scientific article published on November 2011

An environmental enrichment model for mice.

scientific article published on 12 August 2010

An exploratory study of adolescent response to fluoxetine using psychological and biological predictors

scientific article published on 10 January 2018

CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery.

scientific article published on 23 August 2016

CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

scientific article published on 18 May 2016

Cerebellar Learning Properties Are Modulated by the CRF Receptor

scientific article published on 22 June 2018

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

scientific article published on 21 May 2018

Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge.

scientific article

Chronic stress induces sex-specific alterations in methylation and expression of corticotropin-releasing factor gene in the rat

scientific article (publication date: 2011)

Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system.

scientific article published on 31 January 2017

Correction: High-order social interactions in groups of mice.

scientific article published on 11 June 2014

Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood.

scientific article

Determining the role of microRNAs in psychiatric disorders

scientific article published on April 2015

Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment

scientific article

Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice

scientific article

Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex.

scientific article published in March 2011

Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle.

scientific article

Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor.

scientific article

GABA receptors in a state of fear

scientific article published on August 2015

Genetic predisposition for high stress reactivity amplifies effects of early-life adversity.

scientific article published on 3 May 2016

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice.

scientific article

Glucocorticoid-induced leucine zipper "quantifies" stressors and increases male susceptibility to PTSD

scientific article published on 25 July 2019

Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality.

scientific article

High-order social interactions in groups of mice.

scientific article published on 03 September 2013

Homeodomain protein otp and activity-dependent splicing modulate neuronal adaptation to stress

scientific article

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress.

scientific article published on 30 January 2017

Hypothalamic corticotropin-releasing factor is centrally involved in learning under moderate stress.

scientific article published on 8 April 2013

Hypothalamic miR-219 regulates individual metabolic differences in response to diet-induced weight cycling.

scientific article published in February 2018

Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity

scientific article published on 13 February 2013

Identity domains capture individual differences from across the behavioral repertoire

scientific article published on 04 November 2019

Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas.

scientific article

Inferior olive CRF plays a role in motor performance under challenging conditions.

scientific article

Knockdown of corticotropin-releasing factor 1 receptors in the ventral tegmental area enhances conditioned fear

scientific article published on 7 July 2016

Late-Onset Cognitive Impairments after Early-Life Stress Are Shaped by Inherited Differences in Stress Reactivity.

scientific article

Local Optogenetic Induction of Fast (20-40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity

scientific article published on 26 April 2016

Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons

scientific article published on 02 October 2020

MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity

scientific article

MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34.

scientific article published in October 2011

MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1.

scientific article published in November 2014

Minireview: CRF and Wylie Vale: A Story of 41 Amino Acids and a Texan with Grit ⬇️

scientific article published on April 4, 2012

Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids

scientific journal article

Neuro-Epigenetic Indications of Acute Stress Response in Humans: The Case of MicroRNA-29c

scientific article published on 5 January 2016

Overexpression of Corticotropin-Releasing Factor Receptor Type 2 in the Bed Nucleus of Stria Terminalis Improves Posttraumatic Stress Disorder-like Symptoms in a Model of Incubation of Fear ⬇️

scientific article published on July 17, 2013

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

scientific article published on 16 February 2016

Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis

scientific article

Pharmacogenetics of citalopram-related side effects in children with depression and/or anxiety disorders

scientific article published on 20 June 2016

Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties.

scientific article

Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors

scientific article published on 17 May 2013

Placental miR-340 mediates vulnerability to activity based anorexia in mice.

scientific article published on 23 April 2018

Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior.

scientific article

Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 Conveys Acute Stress-Induced Executive Dysfunction

scientific article published on 8 April 2016

Prenatal Exposure to Maternal Obesity Alters Anxiety and Stress Coping Behaviors in Aged Mice.

scientific article

Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation.

scientific article published on 15 June 2010

Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner.

scientific article published in May 2011

Receptor-mediated targeting of a photosensitizer by its conjugation to gonadotropin-releasing hormone analogues.

scientific article published on September 2003

Region-specific roles of the corticotropin-releasing factor-urocortin system in stress.

scientific article

Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor.

scientific article published on March 2011

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice.

scientific article published on 3 October 2010

SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system

scientific article published on 20 November 2015

Selective expression of neuropeptides in the rat mammary gland: somatostatin gene is expressed during lactation

scientific article published on 01 December 1999

Sex differences in corticotropin-releasing factor receptor-1 action within the dorsal raphe nucleus in stress responsivity

scientific article published on 23 October 2013

Sex differences: Transcriptional signatures of stress exposure in male and female brains

scientific article published on 06 February 2020

Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

scientific article published on 27 January 2021

Social context and dominance status contribute to sleep patterns and quality in groups of freely-moving mice

scientific article published on 23 October 2019

Social dominance mediates behavioral adaptation to chronic stress in a sex-specific manner

scientific article published on 09 October 2020

Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides

scientific article published on 11 December 2003

Stable isotope metabolic labeling suggests differential turnover of the DPYSL protein family.

scientific article published on 20 October 2016

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function.

scientific article published on 23 November 2017

Susceptibility to PTSD-like behavior is mediated by corticotropin-releasing factor receptor type 2 levels in the bed nucleus of the stria terminalis.

scientific article published on May 2012

The CRF family of neuropeptides and their receptors - mediators of the central stress response

scientific article published on March 2017

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response

scientific article published on 01 October 2018

The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders.

scientific article published on 15 January 2016

The anxiolytic effect of environmental enrichment is mediated via amygdalar CRF receptor type 1.

scientific article

The effect of magnesium sulfate on the placental corticotropin-releasing factor (CRF) and CRF binding protein mRNA expression in perfused human placental cotyledon.

scientific article

The emerging role of mRNA methylation in normal and pathological behavior.

scientific article

The gonadotropin-releasing hormone family of neuropeptides in the brain of human, bovine and rat: identification of a third isoform

scientific article published on 01 December 1999

Topographical distribution of corticotropin-releasing factor type 2 receptor-like immunoreactivity in the rat dorsal raphe nucleus: co-localization with tryptophan hydroxylase

scientific journal article

Transcriptional Regulation of the Human GnRH II Gene Is Mediated by a Putative cAMP Response Element

article

Trisomy of the G protein-coupled K+channel gene,Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice ⬇️

scientific article published on January 30, 2012

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.

scientific article published on 18 July 2016

Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior.

scientific article

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.

scientific article

Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids.

scientific article published on 21 January 2004

Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits.

scientific article published on 3 November 2009

Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart.

scientific article published on 11 September 2003

Urocortin-dependent effects on adrenal morphology, growth, and expression of steroidogenic enzymes in vivo

scholarly article by Anna Riester published in February 2012

Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior.

scientific article

Urocortins: emerging metabolic and energy homeostasis perspectives

scientific article published on 11 March 2008

Using (15)N-Metabolic Labeling for Quantitative Proteomic Analyses

scientific article published on January 2017

miRNA malfunction causes spinal motor neuron disease

scientific article

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