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List of works by James L. Keck

2009 Pandemic Influenza A H1N1 in Alaska: Temporal and Geographic Characteristics of Spread and Increased Risk of Hospitalization among Alaska Native and Asian/Pacific Islander People ⬇️

scientific article published on January 1, 2011

A Hand-Off Mechanism for Primosome Assembly in Replication Restart

scientific article

A High-Throughput Screening Strategy to Identify Inhibitors of SSB Protein-Protein Interactions in an Academic Screening Facility

scientific article published on 01 June 2017

A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

scientific article published on 08 March 2016

A central role for SSB in Escherichia coli RecQ DNA helicase function.

scientific article

A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases

scientific article published in Nature Communications

Activation/attenuation model for RNase H. A one-metal mechanism with second-metal inhibition.

scientific article

An aromatic-rich loop couples DNA binding and ATP hydrolysis in the PriA DNA helicase

scientific article published on 02 August 2016

Antigenic Variation in Neisseria gonorrhoeae Occurs Independently of RecQ-Mediated Unwinding of the pilE G Quadruplex

scientific article published on 15 January 2020

Binding Mechanism of Metal⋅NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases

scientific article

Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.

scientific article

Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone

scientific article published on 5 November 2010

Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain.

scientific article

Crystal structure of PriB, a component of the Escherichia coli replication restart primosome

scientific article

Crystal structure of the Deinococcus radiodurans single-stranded DNA-binding protein suggests a mechanism for coping with DNA damage.

scientific article

DNA replication at high resolution.

scientific article

Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome

scientific article

Development of Protein-Protein Interaction Inhibitors for the Treatment of Infectious Diseases.

scientific article published on 24 August 2017

Enzymes that push DNA around

scientific article published on 01 October 1999

Examination of the roles of a conserved motif in the PriA helicase in structure-specific DNA unwinding and processivity

scientific article published on 30 July 2021

Function of a strand-separation pin element in the PriA DNA replication restart helicase

scientific article published on 28 December 2018

Genetic recombination in Bacillus subtilis: a division of labor between two single-strand DNA-binding proteins

scientific article

Grip it and rip it: structural mechanisms of DNA helicase substrate binding and unwinding.

scientific article

Hepatitis B virus antibody levels 7 to 9 years after booster vaccination in Alaska native persons

scientific article

High-resolution structure of the E.coli RecQ helicase catalytic core ⬇️

scientific article published on October 1, 2003

Identification of genetic interactions with <i>priB</i> links the PriA/PriB DNA replication restart pathway to double-strand DNA break repair in <i>Escherichia coli</i>

scientific article published in 2022

Identification of the SSB binding site on E. coli RecQ reveals a conserved surface for binding SSB's C terminus.

scientific article published on 03 January 2009

Influences of the N700S Thrombospondin-1 Polymorphism on Protein Structure and Stability

scientific article

Influenza surveillance using electronic health records in the American Indian and Alaska Native population

scientific article

Interaction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity

scientific article published on 22 April 2015

Invasive Haemophilus influenzae Serotype a Infection in Children: Clinical Description of an Emerging Pathogen - Alaska, 2002-2014.

scientific article published on 17 November 2017

Magic spots cast a spell on DNA primase

scientific article published on 01 March 2007

Mechanism of Exonuclease I stimulation by the single-stranded DNA-binding protein.

scientific article

Mechanisms of bacterial DNA replication restart.

scientific article published on 30 November 2017

Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp

scientific article

Neisseria gonorrhoeae RecQ Helicase HRDC Domains Are Essential for Efficient Binding and Unwinding of the pilE Guanine Quartet Structure Required for Pilin Antigenic Variation ⬇️

scientific article published on March 8, 2013

PCV7-induced changes in pneumococcal carriage and invasive disease burden in Alaskan children

scientific article published on 28 September 2014

PriB stimulates PriA helicase via an interaction with single-stranded DNA.

scientific article

Primus inter pares (first among equals).

scientific article published in January 2001

Protein interactions in genome maintenance as novel antibacterial targets

scientific article

RecD2 helicase limits replication fork stress in Bacillus subtilis.

scientific article published on 17 January 2014

RecQ DNA helicase HRDC domains are critical determinants in Neisseria gonorrhoeae pilin antigenic variation and DNA repair.

scientific article published on 11 November 2008

Rising from the Ashes: DNA Repair in Deinococcus radiodurans

scientific article

SSB as an organizer/mobilizer of genome maintenance complexes

scientific article published on 01 September 2008

Single molecule kinetics uncover roles for E. coli RecQ DNA helicase domains and interaction with SSB

scientific article published on 01 September 2018

Sit down, relax and unwind: structural insights into RecQ helicase mechanisms

scientific article

Small-molecule tools for dissecting the roles of SSB/protein interactions in genome maintenance

scientific article

Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator

scientific article

Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins

scientific article published on 22 November 2018

Structural and Functional Studies of H. seropedicae RecA Protein - Insights into the Polymerization of RecA Protein as Nucleoprotein Filament.

scientific article published on 22 July 2016

Structural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from Saccharomyces cerevisiae

scientific article

Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases

scientific article

Structural mechanisms of PriA-mediated DNA replication restart

scientific article

Structure and Biochemical Activities of Escherichia coli MgsA

scientific article

Structure and Cellular Dynamics of Deinococcus radiodurans Single-stranded DNA (ssDNA)-binding Protein (SSB)-DNA Complexes ⬇️

scientific article published on May 7, 2012

Structure and Cellular Roles of the RMI Core Complex from the Bloom Syndrome Dissolvasome

scientific article

Structure and function of RecQ DNA helicases

scientific article published in March 2004

Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11

scientific article

Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQ

scientific article

Structure of the SSB-DNA polymerase III interface and its role in DNA replication

scientific article

Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution

scientific article published in May 2006

Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase

article published in the Proceedings of the National Academy of Sciences of the United States of America

The BLM dissolvasome in DNA replication and repair.

scientific article published on 31 March 2013

The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones

scientific article

The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain

scientific article

The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast

scientific article

Three HRDC domains differentially modulate Deinococcus radiodurans RecQ DNA helicase biochemical activity

scientific article published on 09 March 2006

Werner helicase wings DNA binding.

scientific article

X-ray Crystal Structure of the Bacterial Conjugation Factor PsiB, a Negative Regulator of RecA

scientific article

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