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List of works by Cristina Bottino

2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection

scientific article published on 02 November 2018

2B4 functions as a co-receptor in human NK cell activation

scientific article published in March 2000

Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

scientific article

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

scientific article published on 8 May 2011

Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells

scientific article published on 01 March 2002

Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function.

scientific article published on 24 August 2006

Analysis ofKIR3DP1Polymorphism Provides Relevant Information on CentromericKIRGene Content

scientific article published in August 2018

Biochemical characterization of NK-subset specific triggering surface molecules

scientific article published on 01 February 1991

Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity.

scientific article

CD3+ WT31- peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the alpha/beta heterodimer

scientific article published on 01 July 1987

CD3+4−8−WT31− (T cell receptor γ+) cells and other unusual phenotypes are frequently detected among spontaneously interleukin 2-responsive T lymphocytes present in the joint fluid in juvenile rheumatoid arthritis. A clonal analysis

article

CD4+ cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobulin-like receptor

scientific article published on 01 March 2001

CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity

scientific article (publication date: December 2003)

CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta ⬇️

scientific article published on December 1, 1991

CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies

scientific article published in October 1996

Cell surface expression of activating receptors and co-receptors on peripheral blood NK cells in mixed cryoglobulinemia.

scientific article published on 29 December 2012

Cell surface expression of activating receptors and co-receptors on peripheral blood NK cells in systemic autoimmune diseases ⬇️

scientific article published on May 28, 2012

Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies

scientific article published on 09 August 2019

Cellular and molecular basis of natural killer and natural killer-like activity.

scientific article

Cellular ligands of activating NK receptors.

scientific article

Clonal analysis of CD4-CD8- human thymocytes expressing a T cell receptor gamma/delta chain. Direct evidence for the de novo expression of CD8 surface antigen and of cytolytic activity against tumor targets

scientific article published on 01 November 1988

Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining.

scientific article

Commentary: Regulated equilibrium between opposite signals: a general paradigm for T cell function?

scientific article published on 01 August 2004

Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors

scientific article

DNAM-1 and PVR regulate monocyte migration through endothelial junctions

scientific article

Description of the novelKIR2DL4*035allele identified using high-throughput sequencing

scientific article published on 24 February 2016

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis.

scientific article published on 27 June 2014

Different types of effector cells involved in non-mhc-restricted cytolytic activity

scientific article published on 01 July 1988

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation

scientific article

Effector and regulatory events during natural killer-dendritic cell interactions

scientific article published on December 2006

Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.

scientific article published in August 2008

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

scientific article

Functional characterization of natural killer cells in type I leukocyte adhesion deficiency

scientific article published on 01 February 2007

GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues.

scientific article

Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1.

scientific article published on 18 March 2016

Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells.

scientific article published in June 2004

Human CD3+4-8-WT31- T lymphocyte populations expressing the putative T cell receptor gamma-gene product. A limiting dilution and clonal analysis

scientific article published on 01 September 1987

Human NK cells and NK receptors

scientific article published on 19 December 2013

Human NK cells and their receptors.

scientific article

Human NK receptors: from the molecules to the therapy of high risk leukemias.

scientific article published on 07 May 2011

Human NK-cell receptors

scientific article published on 01 September 2000

Human T lymphocytes expressing TCR gamma/delta

scientific article published on 01 September 1990

Human T lymphocytes expressing gamma/delta T cell antigen receptor

scientific article published on 01 January 1989

Human natural killer cell activating receptors.

scientific article published in December 2000

Human natural killer cell receptors and co-receptors

scientific article

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles

scientific article

Human natural killer cells: their origin, receptors and function

scientific article (publication date: May 2002)

Human natural killer receptors and their ligands

scientific article published on February 2002

Human peripheral blood lymphocytes bearing T cell receptor gamma/delta. Expression of CD8 differentiation antigen correlates with the expression of the 55-kD, C gamma 2-encoded gamma chain.

scientific article published on December 1988

Human thymocytes expressing gamma/delta T-cell receptors

Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells

scientific article

Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis

scientific article

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

scientific article

Identification of a new surface molecule involved in the mechanism of cell to cell adhesion between human NK and tumor target cells ⬇️

scientific article published on January 1, 1993

Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages.

scientific article published on 12 July 2017

Immunobiology of human NK cells

scientific article published on 01 February 2001

In vivo generation of decidual natural killer cells from resident hematopoietic progenitors.

scientific article published on 31 October 2013

Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients.

scientific article published on 6 April 2017

KIR and KIR ligand polymorphism: a new area for clinical applications?

scientific article published on December 2013

Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells.

scientific article published in July 2004

M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages

scientific article published in June 2012

Mesenchymal stromal cells induce peculiar alternatively activated macrophages capable of dampening both innate and adaptive immune responses.

scientific article

Molecular Cloning of NKp46: A Novel Member of the Immunoglobulin Superfamily Involved in Triggering of Natural Cytotoxicity ⬇️

scientific article published on September 7, 1998

Molecular Mechanisms Directing Migration and Retention of Natural Killer Cells in Human Tissues

scientific article published on 11 October 2018

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

scientific article

Monoclonal antibodies which react with the T cell receptor gamma/delta recognize different subsets of CD3+WT31- T lymphocytes

scientific article published on 01 January 1989

NK Cell Function Regulation by TGF-β-Induced Epigenetic Mechanisms

scientific article published on 25 February 2020

NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?

scientific article

NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27

scientific article

NK cells recognize and kill human glioblastoma cells with stem cell-like properties

scientific article

NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis ⬇️

scientific article published on June 15, 1998

NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease

scientific article

Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis.

scientific article

Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.

scientific article

Natural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approaches

scientific article

Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

scientific article

Natural killer cells: a mystery no more.

scientific article

Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells.

scientific article published on 10 April 2013

New perspectives in glioma immunotherapy.

scientific article published on January 2011

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

scientific article published on 11 July 2018

Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1

scientific article published on 11 January 2019

Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages

scientific article published on 16 December 2015

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificitie

scientific article

PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance

scientific article published on 15 July 2015

PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis

scientific article

Phenotypic and functional analysis of human CD3+ and CD3- clones with "lymphokine-activated killer" (LAK) activity. Frequent occurrence of CD3+ LAK clones which produce interleukin-2

scientific article published on 01 October 1987

Physical and functional independency of p70 and p58 natural killer (NK) cell receptors for HLA class I: their role in the definition of different groups of alloreactive NK cell clones.

scientific article published on February 1996

Receptors for HLA class I molecules in human NK cells ⬇️

scientific article published on April 1, 1995

Receptors for HLA class-I molecules in human natural killer cells.

scientific article published on January 1996

Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules.

scientific article

Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor, T44, and T11): analysis of the functional relationship among different pathways of activation.

scientific article

Selective cross-talk among natural cytotoxicity receptors in human natural killer cells

scientific article (publication date: May 2003)

Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells

scientific article published on 01 April 1994

Small round blue cell tumours: diagnostic and prognostic usefulness of the expression of B7-H3 surface molecule

scientific article

Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56bright and CD56dim NK cells.

scientific article

Subpopulations of human NK (CD3-CD16+) lymphocytes identified by monoclonal antibodies directed to clonally distributed functional surface molecules

scientific article published on 01 February 1991

Surface NK receptors and their ligands on tumor cells

scientific article

Surface receptors and functional interactions of human natural killer cells: from bench to the clinic.

scientific article published on October 2003

TGF-β1 Downregulates the Expression of CX3CR1 by Inducing miR-27a-5p in Primary Human NK Cells.

scientific article published on 25 July 2017

TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells

scientific article

The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules

scientific article published on 01 February 1997

The human natural killer cell receptor for major histocompatibility complex class I molecules. Surface modulation of p58 molecules and their linkage to CD3 ζ chain, FcεRI γ chain and the p56lck kinase

scientific article published in October 1994

The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes

scientific article

Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration

scientific article

Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

scientific article

Triggering receptors involved in natural killer cell-mediated cytotoxicity against choriocarcinoma cell lines.

scientific article

Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor.

scientific article

Updated clinical and biological information from the two-stage phase II study of imatinib mesylate in subjects with relapsed/refractory neuroblastoma

scientific article published on 30 July 2018

What is a natural killer cell?

scientific article

X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells

scientific article

X-linked lymphoproliferative disease: the dark side of 2b4 function

scientific article (publication date: 2001)

XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.

scientific article published on 27 February 2014

p46, a novel natural killer cell-specific surface molecule that mediates cell activation

scientific article

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