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List of works by Qun-Ying Lei

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

scientific article

A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation

scientific article published on 14 May 2015

A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

scientific article published on 18 July 2019

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.

scientific article published on 30 June 2016

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth ⬇️

scientific article published on August 8, 2013

Acetylation control of cancer cell metabolism.

scientific article published on January 2014

Acetylation control of metabolic enzymes in cancer: an updated version.

scientific article published on 30 January 2014

Acetylation of Cavin-1 Promotes Lipolysis in White Adipose Tissue.

scientific article published on 30 May 2017

Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer

scientific article published on 30 April 2015

Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease

scientific article published on 25 July 2016

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

scientific article published on 29 May 2020

Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase

scientific article (publication date: 8 July 2011)

Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone

scientific article published on 22 February 2017

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

scientific article

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer

scientific article

BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16

scientific article published in 2022

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

scientific article published on 06 February 2020

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer

scientific article published on 01 September 2018

Cullin 3 targets methionine adenosyltransferase IIα for ubiquitylation-mediated degradation and regulates colorectal cancer cell proliferation

scientific article published on 06 June 2016

Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

scientific article published on 22 June 2022

Estrogen regulates Hippo signaling via GPER in breast cancer

scientific article published on 20 April 2015

G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway.

scientific article published on 09 December 2014

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

scientific article (publication date: 10 April 2009)

Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal.

scientific article published on 21 December 2013

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Harness the power: new insights into the inhibition of YAP/Yorkie.

scientific article published in March 2009

Impact of acetylation on tumor metabolism.

scientific article published on July 2014

Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment

scientific article

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation

scientific article published on 4 January 2016

LDH-A acetylation: implication in cancer.

scientific article published on June 2013

Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.

scientific article published on 23 March 2009

Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer

scientific article

Metabolic recoding of epigenetics in cancer

scientific article published on 21 May 2018

Metabolism remodeling in pancreatic ductal adenocarcinoma

scientific article published on 04 November 2019

Metabolite sensing and signaling in Cancer

scientific article published on 07 July 2020

Metabolite sensing and signaling in cell metabolism

scientific article published on 09 November 2018

Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization

scientific article

NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.

scientific article published in May 2006

NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells

scientific article

NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem-like Cells in Human Non-Small Cell Lung Cancer

scientific article published on 17 April 2017

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

scientific article published in Nature Communications

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

scientific article

Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase

scientific article (publication date: July 2014)

PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction

scientific article

PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ ⬇️

scientific article published on December 28, 2010

Par complex cluster formation mediated by phase separation

scientific article published on 08 May 2020

Perspectives of Reprogramming Breast Cancer Metabolism

scientific article published in January 2017

Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth

scientific article published on 9 January 2017

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

scientific journal article

Regulation of TAZ in cancer

scientific article

Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK

scientific article

Rewiring local immune milieu by boosting dendritic cell for pancreatic cancer treatment

scientific article published on 02 July 2020

Site-Specific Quantification of Protein Palmitoylation by Cysteine-Stable Isotope Metabolic Labeling

scientific article published on 21 August 2018

TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

scientific article

TAZQ233del Hijacks Hippo pathway to promote mesenchymal-epithelial transition in pancreatic adenocarcinoma cells

scholarly article by Chuan-Bo Yao published in September 2018

TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition

scientific article

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer

scientific article published on 20 July 2021

TGF-β1 Modulated the Expression of α5β1 Integrin and Integrin-Mediated Signaling in Human Hepatocarcinoma Cells

scientific article published on 01 August 2000

Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage.

scientific article

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition ⬇️

scientific article published on June 12, 2012

The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.

scientific article

The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer.

scientific article

The regulatory mechanisms and functional roles of the Hippo signaling pathway in breast cancer.

scientific article published in July 2017

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

scientific article

Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats.

scientific article published on 27 December 2005

p300-dependent acetylation of activating transcription factor 5 enhances C/EBPβ transactivation of C/EBPα during 3T3-L1 differentiation

scientific article

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