List of works - Erkki Koivunen

A chimera of green fluorescent protein with gelatinase binding and tumor targeting peptide

scientific article

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

scientific article published on 19 December 2009

A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins

scientific article

A polymeric form of fibronectin has antimetastatic effects against multiple tumor types.

scientific article published in November 1996

A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin alpha(IIb)beta3.

scientific article published in June 2005

Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2 ⬇️

scientific article published on August 22, 1997

Alpha v integrins as receptors for tumor targeting by circulating ligands.

scientific article published in June 1997

AlphaMbeta2 integrin modulator exerts antitumor activity in vivo

scientific article published on November 2007

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis

scientific article

An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.

scientific article

Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro

scientific article published on 01 May 2001

Biology and function of tumor-associated trypsin inhibitor, TATI.

scientific article published on January 1991

Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression

scientific article

Cell-surface interactions of echovirus 22.

scientific article published on August 1997

Characteristics of soluble tumour-derived proteins that inhibit natural killer activity

scientific article published on 01 July 1988

Characterization of a tumor-associated serine protease

scientific article published on 01 May 1988

Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

scientific article

Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells

scientific article

Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment

scientific article published on 17 January 2012

Cyst fluid of ovarian cancer patients contains high concentrations of trypsinogen-2

scientific article published on 01 April 1990

Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia

scientific article

Detection of trypsin- and chymotrypsin-like proteases using p-nitroanilide substrates after sodium dodecyl sulphate polyacrylamide gel electrophoresis

scientific article published on 01 May 1989

Development of novel peptide ligands modulating the enzyme activity of prostate-specific antigen

scientific article

Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration

scientific article published on 01 May 2000

Gelatinase-mediated migration and invasion of cancer cells

scientific article

Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate

scientific article

Human colon carcinoma, fibrosarcoma and leukemia cell lines produce tumor-associated trypsinogen

scientific article published on 01 February 1991

Human ovarian tumor-associated trypsin. Its purification and characterization from mucinous cyst fluid and identification as an activator of pro-urokinase

scientific article published on 01 August 1989

Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides

scientific article published on 01 May 2006

Identification of a negatively charged peptide motif within the catalytic domain of progelatinases that mediates binding to leukocyte beta 2 integrins

scientific article

Identification of novel peptide inhibitors for human trypsins.

scientific article published in February 2010

Identification of novel prostate-specific antigen-binding peptides modulating its enzyme activity.

scientific article

Identification of receptor ligands with phage display peptide libraries

scientific article

In vivo localization of gelatinases (MMP-2 and -9) by in situ zymography with a selective gelatinase inhibitor

scientific article published on 01 September 2001

In vivo targeting of activated leukocytes by a β2-integrin binding peptide

scientific article published on February 2014

Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides

scientific article

Integrin-binding peptides derived from phage display libraries.

scientific article

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.

scientific article

Liquid-chromatographic determination of beta 2-microglobulin, alpha 1-acid glycoprotein, and albumin in urine

scientific article published on 01 October 1987

Metabolism and serum binding of RU 486 in women after various single doses.

scientific article published in July 1987

Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display

scientific article

Novel peptide inhibitors of human kallikrein 2.

scientific article

Peptide inhibition of catalytic and noncatalytic activities of matrix metalloproteinase-9 blocks tumor cell migration and invasion.

scientific article published on 30 April 2004

Peptide-mediated delivery of therapeutic and imaging agents into mammalian cells.

scientific article

Peptides in cell adhesion research

scientific article

Peptides in cell adhesion: powerful tools for the study of integrin-ligand interactions.

scientific article published on September 1996

Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins

scientific article

Radionuclide imaging of tumor xenografts in mice using a gelatinase-targeting peptide

scientific article published on 01 January 2005

Reaction of a tumour-associated trypsin inhibitor with serine proteinases associated with coagulation and tumour invasion

scientific article published on September 1988

Regulation of cell adhesion: a collaborative effort of integrins, their ligands, cytoplasmic actors, and phosphorylation

scientific article published on 11 November 2019

Role of leukemia cell invadosome in extramedullary infiltration

scientific article published on 27 July 2009

Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library.

scientific article published on September 1993

Serum samples from pancreatectomized patients contain trypsinogen immunoreactivity

scientific article published on 01 July 1996

Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment

scientific article published in March 2006

Steps toward mapping the human vasculature by phage display.

scientific article

Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens

scientific article

Targeting neuropilin-1 in human leukemia and lymphoma

scientific article

Targeting of phage display vectors to mammalian cells

scientific article

The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation

scientific article

Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.

scientific article published on 5 December 2017

Time-resolved immunofluorometric assays for trypsinogen-1 and 2 in serum reveal preferential elevation of trypsinogen-2 in pancreatitis

scientific article published on 01 June 1990

Tumor targeting with a selective gelatinase inhibitor

scientific article

Tumor-associated trypsin participates in cancer cell-mediated degradation of extracellular matrix

scientific article published on 01 April 1991

Tumour-associated trypsin inhibitor, TATI. Clinical use and biological function

scientific article published on January 1989

Use of intein-directed peptide biosynthesis to improve serum stability and bioactivity of a gelatinase inhibitory peptide.

scientific article

Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients

scientific article

Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction

scientific article published on 01 October 2000

List of works by Erkki Koivunen

A chimera of green fluorescent protein with gelatinase binding and tumor targeting peptide

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins

A polymeric form of fibronectin has antimetastatic effects against multiple tumor types.

A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin alpha(IIb)beta3.

Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2 ⬇️

Alpha v integrins as receptors for tumor targeting by circulating ligands.

AlphaMbeta2 integrin modulator exerts antitumor activity in vivo

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis

An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.

Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro

Biology and function of tumor-associated trypsin inhibitor, TATI.

Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression

Cell-surface interactions of echovirus 22.

Characteristics of soluble tumour-derived proteins that inhibit natural killer activity

Characterization of a tumor-associated serine protease

Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells

Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment

Cyst fluid of ovarian cancer patients contains high concentrations of trypsinogen-2

Design, development, and validation of a high-throughput drug-screening assay for targeting of human leukemia

Detection of trypsin- and chymotrypsin-like proteases using p-nitroanilide substrates after sodium dodecyl sulphate polyacrylamide gel electrophoresis

Development of novel peptide ligands modulating the enzyme activity of prostate-specific antigen

Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration

Gelatinase-mediated migration and invasion of cancer cells

Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate

Human colon carcinoma, fibrosarcoma and leukemia cell lines produce tumor-associated trypsinogen

Human ovarian tumor-associated trypsin. Its purification and characterization from mucinous cyst fluid and identification as an activator of pro-urokinase

Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides

Identification of a negatively charged peptide motif within the catalytic domain of progelatinases that mediates binding to leukocyte beta 2 integrins

Identification of novel peptide inhibitors for human trypsins.

Identification of novel prostate-specific antigen-binding peptides modulating its enzyme activity.

Identification of receptor ligands with phage display peptide libraries

In vivo localization of gelatinases (MMP-2 and -9) by in situ zymography with a selective gelatinase inhibitor

In vivo targeting of activated leukocytes by a β2-integrin binding peptide

Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides

Integrin-binding peptides derived from phage display libraries.

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.

Liquid-chromatographic determination of beta 2-microglobulin, alpha 1-acid glycoprotein, and albumin in urine

Metabolism and serum binding of RU 486 in women after various single doses.

Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display

Novel peptide inhibitors of human kallikrein 2.

Peptide inhibition of catalytic and noncatalytic activities of matrix metalloproteinase-9 blocks tumor cell migration and invasion.

Peptide-mediated delivery of therapeutic and imaging agents into mammalian cells.

Peptides in cell adhesion research

Peptides in cell adhesion: powerful tools for the study of integrin-ligand interactions.

Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins

Radionuclide imaging of tumor xenografts in mice using a gelatinase-targeting peptide

Reaction of a tumour-associated trypsin inhibitor with serine proteinases associated with coagulation and tumour invasion

Regulation of cell adhesion: a collaborative effort of integrins, their ligands, cytoplasmic actors, and phosphorylation

Role of leukemia cell invadosome in extramedullary infiltration

Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library.

Serum samples from pancreatectomized patients contain trypsinogen immunoreactivity

Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment

Steps toward mapping the human vasculature by phage display.

Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens

Targeting neuropilin-1 in human leukemia and lymphoma

Targeting of phage display vectors to mammalian cells

The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation

Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.

Time-resolved immunofluorometric assays for trypsinogen-1 and 2 in serum reveal preferential elevation of trypsinogen-2 in pancreatitis

Tumor targeting with a selective gelatinase inhibitor

Tumor-associated trypsin participates in cancer cell-mediated degradation of extracellular matrix

Tumour-associated trypsin inhibitor, TATI. Clinical use and biological function

Use of intein-directed peptide biosynthesis to improve serum stability and bioactivity of a gelatinase inhibitory peptide.

Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients

Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction