List of works by Kevin A. Kavanagh

A 4'-phosphopantetheinyl transferase mediates non-ribosomal peptide synthetase activation in Aspergillus fumigatus

scientific article

A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus

scientific article

A novel technique for studying the adherence of Candida albicans to HEp-2 cells

A rapid method for the extraction of whole cell proteins from Candida species

article

A study of the role of apoptotic cell death and cell cycle events mediating the mechanism of action of 6-hydroxycoumarin-3-carboxylatosilver in human malignant hepatic cells

scientific article published on 28 November 2006

Absence of correlation between chemo- and radioresistance in a range of human tumour cell lines.

scientific article

Activation of Neutrophils via IP3 Pathway Following Exposure to Demodex-Associated Bacterial Proteins.

scientific article published on 3 October 2015

Adherence of clinical isolates of Saccharomyces cerevisiae to buccal epithelial cells

scientific article published on 01 February 2001

An in vitro investigation of the induction of apoptosis and modulation of cell cycle events in human cancer cells by bisphenanthroline-coumarin-6,7-dioxacetatocopper(II) complex.

scientific article published on 19 April 2007

Analysis of major intracellular proteins of Aspergillus fumigatus by MALDI mass spectrometry: identification and characterisation of an elongation factor 1B protein with glutathione transferase activity

scientific article

Analysis of the acute response of Galleria mellonella larvae to potassium nitrate

scientific article published on 20 February 2017

Analysis of the early cellular and humoral responses of Galleria mellonella larvae to infection by Candida albicans

scientific article

Analysis of the effect of temperature on protein abundance in Demodex-associated Bacillus oleronius

scientific article published on 01 June 2018

Analysis of the response of Candida albicans cells to Silver(I).

scientific article published in May 2010

Apoptotic cell death: a possible key event in mediating the in vitro anti-proliferative effect of a novel copper(II) complex, [Cu(4-Mecdoa)(phen)(2)] (phen=phenanthroline, 4-Mecdoa=4-methylcoumarin-6,7-dioxactetate), in human malignant cancer cells.

scientific article

Application of protoplast fusion to the nonconventional yeast

Application of the Melle-Boinot process to the fermentation of xylose by Pachysolen tannophilus

scientific article published in 1994

Assessment of in vivo antimicrobial activity of the carbene silver(I) acetate derivative SBC3 using Galleria mellonella larvae

scientific article published on 19 July 2014

Autoclaved Polyethylene Glycol decreases yeast protoplast reversion and hybrid production

article

Baculovirus expression of parvovirus B19 (B19V) NS1: utility in confirming recent infection.

scientific article

Caffeine administration alters the behaviour and development of Galleria mellonella larvae

scientific article

Candida Urinary Tract Infection: Pathogenesis

scientific article published on 01 May 2011

Caspofungin primes the immune response of the larvae of Galleria mellonella and induces a non-specific antimicrobial response ⬇️

scientific article published on October 14, 2010

Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis.

scientific article published on 28 June 2018

Characterization of the Proteomic Response of A549 Cells Following Sequential Exposure to Aspergillus fumigatus and Pseudomonas aeruginosa

scientific article published on 14 November 2019

Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella

scientific article published on July 2004

Correlation between ocular Demodex infestation and serum immunoreactivity to Bacillus proteins in patients with Facial rosacea

scientific article

Correlation between serum reactivity to Demodex-associated Bacillus oleronius proteins, and altered sebum levels and Demodex populations in erythematotelangiectatic rosacea patients

scientific article published on 18 November 2013

Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae

scholarly article by M Brennan published 11 October 2002 in FEMS Immunology and Medical Microbiology

Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae.

scientific article published on October 2002

Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis

scientific article published on 01 January 2020

Culture filtrates of Aspergillus fumigatus induce different modes of cell death in human cancer cell lines

article

Deciphering the antimicrobial activity of phenanthroline chelators.

scientific article published on January 2012

Demodex-associated bacterial proteins induce neutrophil activation

scientific article published on 02 March 2012

Dermatophytes and other fungi associated with skin mycoses in Tripoli, Libya.

scientific article published in April 2002

Detection of Aspergillus fumigatus mycotoxins: immunogen synthesis and immunoassay development.

scientific article published in February 2004

Development of an insect model for the in vivo pathogenicity testing of yeasts

article

Disruption of haemocyte function by exposure to cytochalasin b or nocodazole increases the susceptibility of Galleria mellonella larvae to infection.

scientific article published on 7 July 2011

Disruption of mitochondrial function in Candida albicans leads to reduced cellular ergosterol levels and elevated growth in the presence of amphotericin B.

scientific article published on 15 March 2003

Dose-dependent cellular and humoral responses in Galleria mellonella larvae following beta-glucan inoculation.

scientific article published on 24 November 2009

Effect of N-chlorotaurine on Aspergillus, with particular reference to destruction of secreted gliotoxin

scientific article published on 01 July 2006

Effect of novel triazole-amino acid hybrids on growth and virulence of Candida species: in vitro and in vivo studies

scientific article published on 13 October 2016

Effect of nutrient deprivation on the susceptibility of Galleria mellonella larvae to infection.

scientific article

Effect of pre-incubation temperature on susceptibility of Galleria mellonella larvae to infection by Candida albicans

scientific article published on 6 October 2007

Emergence of Saccharomyces cerevisiae as a human pathogen

Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)

article

Erythromycin, an inhibitor of mitoribosomal protein biosynthesis, alters the amphotericin B susceptibility of Candida albicans

scientific article published in February 2003

Evaluation of Galleria mellonella larvae as an in vivo model for assessing the relative toxicity of food preservative agents.

scientific article published on 27 April 2016

Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suis.

scientific article

Exposure of Aspergillus fumigatus to caspofungin results in the release, and de novo biosynthesis, of gliotoxin.

scientific article published in February 2013

Exposure of Staphylococcus aureus to silver(I) induces a short term protective response

scientific article published on 26 April 2012

Exposure of a corneal epithelial cell line (hTCEpi) to Demodex-associated Bacillus proteins results in an inflammatory response.

scientific article published on 2 October 2014

Exposure of the yeast Candida albicans to the anti-neoplastic agent adriamycin increases the tolerance to amphotericin B.

scientific article

Exposure to N-chlorotaurine induces oxidative stress responses in Aspergillus fumigatus

scientific article published on 13 December 2018

Exposure to caspofungin activates Cap and Hog pathways in Candida albicans.

scientific article published in November 2009

Extensive proteomic remodeling is induced by eukaryotic translation elongation factor 1Bγ deletion in Aspergillus fumigatus

scientific article published on 30 September 2013

Fluctuations in haemocyte density and microbial load may be used as indicators of fungal pathogenicity in larvae of Galleria mellonella.

scientific article

Funcelase — An efficient preparation for the isolation of reversion competent protoplasts from yeasts

Fungi:Biology and Applications

article by Kevin Kavanagh

Galleria mellonella as a host model to study Aspergillus terreus virulence and amphotericin B resistance.

scientific article published on 24 June 2015

Galleria mellonella as a model for fungal pathogenicity testing.

scientific article published on January 2012

Gliotoxin effects on fungal growth: mechanisms and exploitation.

scientific article published on March 2012

Glycosylated metal chelators as anti-parasitic agents with tunable selectivity.

scientific article

Histatins: antimicrobial peptides with therapeutic potential

scientific article published on March 2004

Identification, cloning, and functional expression of three glutathione transferase genes from Aspergillus fumigatus

scientific article

In vitro anti-tumour and cyto-selective effects of coumarin-3-carboxylic acid and three of its hydroxylated derivatives, along with their silver-based complexes, using human epithelial carcinoma cell lines.

scientific article published on 25 September 2006

In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes

scientific article published on 01 June 2018

Induction of apoptosis in yeast and mammalian cells by exposure to 1,10-phenanthroline metal complexes.

scientific article published on February 2004

Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates

scientific article published on 09 October 2018

Inhibition of neutrophil function following exposure to the Aspergillus fumigatus toxin fumagillin.

scientific article published on 4 March 2010

Innate humoral immune defences in mammals and insects: The same, with differences ?

scientific article published on 01 January 2018

Isolation, activity and immunological characterisation of a secreted aspartic protease, CtsD, from Aspergillus fumigatus

scientific article published on 24 December 2006

Medical Mycology: Cellular and Molecular Techniques

textbook

Membrane changes associated with the early stages of apoptosis in HEp-2 cells decrease susceptibility to adherence byCandida albicans

scientific article published on 01 May 1997

Mite-related bacterial antigens stimulate inflammatory cells in rosacea.

scientific article

Mode of anti-fungal activity of 1,10-phenanthroline and its Cu(II), Mn(II) and Ag(I) complexes.

scientific article

Monoclonal antibodies directed against extracellular matrix proteins reduce the adherence of Candida albicans to HEp-2 cells.

scientific article published on January 1998

Natural Product-Based 1,2,3-Triazole/Sulfonate Analogues as Potential Chemotherapeutic Agents for Bacterial Infections

scientific article published on 26 June 2018

New Insights in Medical Mycology

scholarly article published 2007

Nonribosomal peptide synthetase genes pesL and pes1 are essential for Fumigaclavine C production in Aspergillus fumigatus

scientific article

Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation

scientific article

Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity

scientific article published on 14 March 2011

Oosporein, an abundant metabolite in Beauveria caledonica, with a feedback induction mechanism and a role in insect virulence

scientific article published on 28 January 2019

Physical stress primes the immune response of Galleria mellonella larvae to infection by Candida albicans

scientific article

Positive correlation between serum immunoreactivity toDemodex-associatedBacillusproteins and erythematotelangiectatic rosacea

scientific article published on 25 September 2012

Potential role of Demodex mites and bacteria in the induction of rosacea

scientific article

Pre-exposure of Galleria mellonella larvae to different doses of Aspergillus fumigatus conidia causes differential activation of cellular and humoral immune responses.

scientific article published on September 2011

Pre-exposure to yeast protects larvae of Galleria mellonella from a subsequent lethal infection by Candida albicans and is mediated by the increased expression of antimicrobial peptides

scientific article

Prolonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection

scientific article published on 18 March 2015

Proteomic Analysis of the Responses of during Infection of Larvae

article

Proteomic analysis of Bayvarol®resistance mechanisms in the honey bee parasiteVarroa destructor

Proteomic analysis of proteins released from growth-arrested Candida albicans following exposure to caspofungin

scientific article

Proteomic characterisation of the summer–winter transition in Apis mellifera

scientific article published in 2022

Proteomic response of Trichoderma aggressivum f. europaeum to Agaricus bisporus tissue and mushroom compost

article

Quantitative detection of C-reactive protein using phosphocholine-labelled enzyme or microspheres

scientific article published in January 2003

Quantitative proteomics reveals divergent responses in Apis mellifera worker and drone pupae to parasitization by Varroa destructor.

scientific article published on 19 December 2017

Role of cell cycle events and apoptosis in mediating the anti-cancer activity of a silver(I) complex of 4-hydroxy-3-nitro-coumarin-bis(phenanthroline) in human malignant cancer cells.

scientific article

Self-protection against gliotoxin--a component of the gliotoxin biosynthetic cluster, GliT, completely protects Aspergillus fumigatus against exogenous gliotoxin

scientific article

Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity.

scientific article published on 5 April 2012

Single-pot derivatisation strategy for enhanced gliotoxin detection by HPLC and MALDI-ToF mass spectrometry

scientific article

Stability of antibacterial Te(IV) compounds: A combined experimental and computational study

scientific article published on 28 May 2019

Steroid-AuI -NHC Complexes: Synthesis and Antibacterial Activity.

scientific article published on 2 May 2017

Superoxide production in Galleria mellonella hemocytes: identification of proteins homologous to the NADPH oxidase complex of human neutrophils

scientific article

Susceptibility of larvae of Galleria mellonella to infection by Aspergillus fumigatus is dependent upon stage of conidial germination.

scientific article published in June 2006

Synthesis and antimicrobial activity of (Z)-3-(1H-imidazol-1-yl)-2-phenylpropenenitrile and its metal complexes: X-ray crystal structures of the Zn(II) and Ag(I) complexes

Synthesis and mechanistic studies of diketo acids and their bioisosteres as potential antibacterial agents

scientific article published on 22 November 2018

Synthesis, antibacterial and anti-MRSA activity, in vivo toxicity and a structure-activity relationship study of a quinoline thiourea.

scientific article

Targeted disruption of nonribosomal peptide synthetase pes3 augments the virulence of Aspergillus fumigatus

scientific article

The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis

scientific article

The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus

scientific article published on 21 June 2018

The Use of Larvae to Identify Novel Antimicrobial Agents against Fungal Species of Medical Interest

scientific article published on 19 September 2018

The effect of Aspergillus fumigatus infection on vitamin D receptor expression in cystic fibrosis.

scientific article

The effect of entomopathogenic fungal culture filtrate on the immune response and haemolymph proteome of the large pine weevil, Hylobius abietis

scientific article published on 17 July 2018

The effect of entomopathogenic fungal culture filtrate on the immune response of the greater wax moth, Galleria mellonella.

scientific article published on 22 May 2017

The expression of selected non-ribosomal peptide synthetases in Aspergillus fumigatus is controlled by the availability of free iron

scientific article

The innate immune response to Aspergillus fumigatus at the alveolar surface.

scientific article published on 30 April 2015

The role of altered cutaneous immune responses in the induction and persistence of rosacea.

scientific article

The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus

scientific article published on April 2011

Thermal and physical stresses induce a short-term immune priming effect in Galleria mellonella larvae

scientific article published on 20 February 2014

Translocation of proteins homologous to human neutrophil p47phox and p67phox to the cell membrane in activated hemocytes of Galleria mellonella.

scientific article published on 2 August 2006

Trichophyton violaceum is the dominant cause of tinea capitis in children in Tripoli, Libya: results of a two year survey

scientific article

Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1,10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Selectivity, and Lower Toxicity in Comparison to Their Copper(II) Analogs

scientific article published on 02 July 2018

Use of Galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [Ag2(mal)(phen)3].

scientific article published on 12 December 2008

Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development

article

Yeasts of the genus Candida are the dominant cause of onychomycosis in Libyan women but not men: results of a 2-year surveillance study.

scientific article

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