List of works - Ian Eggleston

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.

scientific article published on 24 July 2009

5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy

scientific article

A convenient synthesis of cyclic peptides as regioselectively addressable functionalized templates (RAFT)

A fluorescent Arg-Gly-Asp (RGD) peptide-naphthalenediimide (NDI) conjugate for imaging integrin α(v)β(3) in vitro

scientific article

A novel flow cytometry assay using dihydroethidium as redox-sensitive probe reveals NADPH oxidase-dependent generation of superoxide anion in human platelets exposed to amyloid peptide β.

scientific article

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential.

scientific article

An intestinal paracellular pathway biased toward positively-charged macromolecules

scientific article published on 06 September 2018

Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

scientific article

Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase

scientific article published in August 2003

Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases

scientific article

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

scientific article published on 17 October 2018

Codelivery of a cytotoxin and photosensitiser via a liposomal nanocarrier: a novel strategy for light-triggered cytosolic release

scientific article published on 01 November 2018

Development of a peptide-based fluorescent probe for biological heme monitoring

scientific article published on 01 January 2019

Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate

scientific article

Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

scientific article published on February 2003

Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines.

scientific article

Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation.

scientific article published on 14 May 2015

Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

scientific article

Fluorescence lifetime imaging and FRET-induced intracellular redistribution of Tat-conjugated quantum dot nanoparticles through interaction with a phthalocyanine photosensitiser

scientific article

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties

scientific article

Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization

scientific article

Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia.

scientific article published on 31 March 2018

Natural Product–Guided Discovery of a Fungal Chitinase Inhibitor

scientific article

Natural product family 18 chitinase inhibitors

scientific article

Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid

scientific article published on 22 June 2007

Oriented immobilisation of engineered single-chain antibodies to develop biosensors for virus detection

scientific article published on 20 January 2006

Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate.

scientific article

Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism.

scientific article

SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation

scientific article

Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor

scientific article published on 14 July 2006

Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrugs.

scientific article published on March 2010

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold.

scientific article published on 13 November 2008

Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme

scientific article

Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway

scientific article

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

scientific article

Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

scientific article

Structure-based exploration of cyclic dipeptide chitinase inhibitors

scientific article published in November 2004

Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

scientific article

The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate

scientific article

The use of dipeptide derivatives of 5-aminolaevulinic acid promotes their entry to tumor cells and improves tumor selectivity of photodynamic therapy

scientific article published on 17 December 2014

Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products

scientific article published on 21 November 2005

Total Synthesis of Dolatrienoic Acid: A Subunit of Dolastatin 14

scientific article published on 01 May 1997

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

scientific article published on 20 March 2009

List of works by Ian Eggleston

1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.

5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy

A convenient synthesis of cyclic peptides as regioselectively addressable functionalized templates (RAFT)

A fluorescent Arg-Gly-Asp (RGD) peptide-naphthalenediimide (NDI) conjugate for imaging integrin α(v)β(3) in vitro

A novel flow cytometry assay using dihydroethidium as redox-sensitive probe reveals NADPH oxidase-dependent generation of superoxide anion in human platelets exposed to amyloid peptide β.

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential.

An intestinal paracellular pathway biased toward positively-charged macromolecules

Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase

Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

Codelivery of a cytotoxin and photosensitiser via a liposomal nanocarrier: a novel strategy for light-triggered cytosolic release

Development of a peptide-based fluorescent probe for biological heme monitoring

Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate

Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase

Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines.

Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation.

Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Fluorescence lifetime imaging and FRET-induced intracellular redistribution of Tat-conjugated quantum dot nanoparticles through interaction with a phthalocyanine photosensitiser

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties

Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization

Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia.

Natural Product–Guided Discovery of a Fungal Chitinase Inhibitor

Natural product family 18 chitinase inhibitors

Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid

Oriented immobilisation of engineered single-chain antibodies to develop biosensors for virus detection

Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate.

Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism.

SPPS of the natural product chitinase inhibitor argifin: library generation and biological evaluation

Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor

Skin protection against UVA-induced iron damage by multiantioxidants and iron chelating drugs/prodrugs.

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold.

Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme

Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway

Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis

Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

Structure-based exploration of cyclic dipeptide chitinase inhibitors

Synthesis and structure-based dissection of cyclic peptide chitinase inhibitors: new leads for antifungal and anti-inflammatory drugs

The cancer chemopreventive actions of phytochemicals derived from glucosinolates

The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate

The use of dipeptide derivatives of 5-aminolaevulinic acid promotes their entry to tumor cells and improves tumor selectivity of photodynamic therapy

Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products

Total Synthesis of Dolatrienoic Acid: A Subunit of Dolastatin 14

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents