List of works - Toshihide Okajima

A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet.

scientific article

Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1

scientific article

An Unusual Subtilisin-like Serine Protease Is Essential for Biogenesis of Quinohemoprotein Amine Dehydrogenase ⬇️

scientific article published on January 10, 2012

Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases.

scientific article published on 21 December 2016

Bio-nanocapsules displaying various immunoglobulins as an active targeting-based drug delivery system.

scientific article

Cellular uptake of hepatitis B virus envelope L particles is independent of sodium taurocholate cotransporting polypeptide, but dependent on heparan sulfate proteoglycan

scientific article published on 12 July 2016

Characterization of H-box region mutants of WalK inert to the action of waldiomycin in Bacillus subtilis.

scientific article published in July 2017

Chemical and kinetic reaction mechanisms of quinohemoprotein amine dehydrogenase from Paracoccus denitrificans.

scientific article published in September 2003

Chemical modification of tryptophan residues and stability changes in proteins

scientific article published on 01 October 1990

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

scientific article

Crystal structures of cytochrome c(L) and methanol dehydrogenase from Hyphomicrobium denitrificans: structural and mechanistic insights into interactions between the two proteins.

scientific article published in March 2006

Cytokine-dependent activation of JAK-STAT pathway in Saccharomyces cerevisiae

scientific article published on 2 March 2016

Detection of the reaction intermediates catalyzed by a copper amine oxidase

scientific article

Efficient bacterial production of functional antibody fragments using a phagemid vector

scientific article

Exchange of nucleoside monophosphate-binding domains in adenylate kinase and UMP/CMP kinase.

scientific article

Expression of squamous cell carcinoma antigen-1 in liver enhances the uptake of hepatitis B virus envelope-derived bio-nanocapsules in transgenic rats.

scientific article published in November 2008

Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor

scientific article published on 10 February 2021

Further insight into the mechanism of stereoselective proton abstraction by bacterial copper amine oxidase

scientific article

Gene cloning, recombinant expression, purification and characterization of l-methionine decarboxylase from Streptomyces sp. 590.

scientific article published on 21 December 2016

High-resolution crystal structure of copper amine oxidase from Arthrobacter globiformis: assignment of bound diatomic molecules as O2

scientific article

Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1

scientific article (publication date: 16 January 2004)

Identification of genes essential for the biogenesis of quinohemoprotein amine dehydrogenase

scientific article published on 28 January 2014

Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta.

scientific article

In crystallo thermodynamic analysis of conformational change of the topaquinone cofactor in bacterial copper amine oxidase

scientific article published on 18 December 2018

In vivo delivery of bionanocapsules displaying Phaseolus vulgaris agglutinin-L4 isolectin to malignant tumors overexpressing N-acetylglucosaminyltransferase V.

scientific article

In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S region.

scientific article

Initial repertoire of anti-(4-hydroxy-3-nitrophenylacetyl) antibodies as potential donors for effective affinity maturation

scientific article published on 9 January 2006

Involvement of a putative [Fe-S]-cluster-binding protein in the biogenesis of quinohemoprotein amine dehydrogenase.

scientific article

Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK

scientific article published on 23 April 2012

Kinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase

scientific article published on 01 April 2006

Mutational analysis of hepatitis B virus pre-S1 (9-24) fusogenic peptide.

scientific article

Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing

scientific article published on 05 May 2020

Novel antibacterial compounds specifically targeting the essential WalR response regulator.

scientific article published on 29 January 2010

Novel trimeric adenylate kinase from an extremely thermoacidophilic archaeon, Sulfolobus solfataricus: molecular cloning, nucleotide sequencing, expression in Escherichia coli, and characterization of the recombinant enzyme.

scientific article

Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins

scientific article (publication date: 17 June 2005)

Probing the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter globiformis with Halide Ions.

scientific article

Reinvestigation of metal ion specificity for quinone cofactor biogenesis in bacterial copper amine oxidase.

scientific article

Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif

scientific article

Role of copper ion in bacterial copper amine oxidase: spectroscopic and crystallographic studies of metal-substituted enzymes

scientific article

Site-directed mutagenesis of AMP-binding residues in adenylate kinase. Alteration of substrate specificity

scientific article published on 01 November 1993

Spectroscopic observation of intermediates formed during the oxidative half-reaction of copper/topa quinone-containing phenylethylamine oxidase.

scientific article published in December 2001

Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors

scientific article published on 07 October 2011

Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions

scientific article

The Radical S-Adenosyl-L-methionine Enzyme QhpD Catalyzes Sequential Formation of Intra-protein Sulfur-to-Methylene Carbon Thioether Bonds

scientific article

The covalent structure of the small subunit from Pseudomonas putida amine dehydrogenase reveals the presence of three novel types of internal cross-linkages, all involving cysteine in a thioether bond.

scientific article published on 12 September 2001

Trapping of a dopaquinone intermediate in the TPQ cofactor biogenesis in a copper-containing amine oxidase from Arthrobacter globiformis

scientific article

Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.

scientific article published on 8 January 2010

X-ray crystal structure of the DNA-binding domain of response regulator WalR essential to the cell viability of staphylococcus aureus and interaction with target DNA.

scientific article published on 7 September 2010

List of works by Toshihide Okajima

A short-chain dehydrogenase involved in terpene metabolism from Zingiber zerumbet.

Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1

An Unusual Subtilisin-like Serine Protease Is Essential for Biogenesis of Quinohemoprotein Amine Dehydrogenase ⬇️

Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases.

Bio-nanocapsules displaying various immunoglobulins as an active targeting-based drug delivery system.

Cellular uptake of hepatitis B virus envelope L particles is independent of sodium taurocholate cotransporting polypeptide, but dependent on heparan sulfate proteoglycan

Characterization of H-box region mutants of WalK inert to the action of waldiomycin in Bacillus subtilis.

Chemical and kinetic reaction mechanisms of quinohemoprotein amine dehydrogenase from Paracoccus denitrificans.

Chemical modification of tryptophan residues and stability changes in proteins

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

Crystal structures of cytochrome c(L) and methanol dehydrogenase from Hyphomicrobium denitrificans: structural and mechanistic insights into interactions between the two proteins.

Cytokine-dependent activation of JAK-STAT pathway in Saccharomyces cerevisiae

Detection of the reaction intermediates catalyzed by a copper amine oxidase

Efficient bacterial production of functional antibody fragments using a phagemid vector

Exchange of nucleoside monophosphate-binding domains in adenylate kinase and UMP/CMP kinase.

Expression of squamous cell carcinoma antigen-1 in liver enhances the uptake of hepatitis B virus envelope-derived bio-nanocapsules in transgenic rats.

Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor

Further insight into the mechanism of stereoselective proton abstraction by bacterial copper amine oxidase

Gene cloning, recombinant expression, purification and characterization of l-methionine decarboxylase from Streptomyces sp. 590.

High-resolution crystal structure of copper amine oxidase from Arthrobacter globiformis: assignment of bound diatomic molecules as O2

Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1

Identification of genes essential for the biogenesis of quinohemoprotein amine dehydrogenase

Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta.

In crystallo thermodynamic analysis of conformational change of the topaquinone cofactor in bacterial copper amine oxidase

In vivo delivery of bionanocapsules displaying Phaseolus vulgaris agglutinin-L4 isolectin to malignant tumors overexpressing N-acetylglucosaminyltransferase V.

In vivo protein delivery to human liver-derived cells using hepatitis B virus envelope pre-S region.

Initial repertoire of anti-(4-hydroxy-3-nitrophenylacetyl) antibodies as potential donors for effective affinity maturation

Involvement of a putative [Fe-S]-cluster-binding protein in the biogenesis of quinohemoprotein amine dehydrogenase.

Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK

Kinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase

Mutational analysis of hepatitis B virus pre-S1 (9-24) fusogenic peptide.

Neutron crystallography of copper amine oxidase reveals keto/enolate interconversion of the quinone cofactor and unusual proton sharing

Novel antibacterial compounds specifically targeting the essential WalR response regulator.

Novel trimeric adenylate kinase from an extremely thermoacidophilic archaeon, Sulfolobus solfataricus: molecular cloning, nucleotide sequencing, expression in Escherichia coli, and characterization of the recombinant enzyme.

Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteins

Probing the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter globiformis with Halide Ions.

Reinvestigation of metal ion specificity for quinone cofactor biogenesis in bacterial copper amine oxidase.

Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif

Role of copper ion in bacterial copper amine oxidase: spectroscopic and crystallographic studies of metal-substituted enzymes

Site-directed mutagenesis of AMP-binding residues in adenylate kinase. Alteration of substrate specificity

Spectroscopic observation of intermediates formed during the oxidative half-reaction of copper/topa quinone-containing phenylethylamine oxidase.

Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors

Studies on an acetylcholine binding protein identify a basic residue in loop G on the β1 strand as a new structural determinant of neonicotinoid actions

The Radical S-Adenosyl-L-methionine Enzyme QhpD Catalyzes Sequential Formation of Intra-protein Sulfur-to-Methylene Carbon Thioether Bonds

The covalent structure of the small subunit from Pseudomonas putida amine dehydrogenase reveals the presence of three novel types of internal cross-linkages, all involving cysteine in a thioether bond.

Trapping of a dopaquinone intermediate in the TPQ cofactor biogenesis in a copper-containing amine oxidase from Arthrobacter globiformis

Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.

X-ray crystal structure of the DNA-binding domain of response regulator WalR essential to the cell viability of staphylococcus aureus and interaction with target DNA.