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List of works by Jeffery D. Molkentin

A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo

scientific article

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

scientific article published on 20 April 2016

A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression.

scientific article

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

scientific article

A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility

scientific article published on 2 February 2012

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function

scientific article (publication date: 8 July 2011)

A friend within the heart: natriuretic peptide receptor signaling ⬇️

scientific article published on May 1, 2003

A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation

scientific article published in September 2003

A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning

article

A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila.

scientific article

A threshold of GATA4 and GATA6 expression is required for cardiovascular development

scholarly article

A thrombospondin-dependent pathway for a protective ER stress response

scientific article

ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice

scientific article published on 08 October 2009

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases

scientific article published on 20 December 2012

Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells

scientific article

Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+Channels in Arterial Smooth Muscle and Contributes to Hypertension

scientific article published in Journal of Biological Chemistry

Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

scientific article published on 26 July 2016

Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction

scientific article published on 09 May 2006

Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax.

scientific article published on June 2009

Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy

scientific article

Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice

scientific article

An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels

scientific article published on 27 June 2017

An emerging consensus on cardiac regeneration

scientific article published on December 2014

Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.

scientific article

Animal models of heart failure: a scientific statement from the American Heart Association

scientific article published on 17 May 2012

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

scientific journal article

Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway

scientific article

Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast ⬇️

Are Resident c-Kit + Cardiac Stem Cells Really All That Are Needed to Mend a Broken Heart?

scientific article published on 01 October 2013

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.

scientific article published on 17 November 2017

BEX1 is an RNA-dependent mediator of cardiomyopathy

scientific article published on 30 November 2017

Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin

scientific article published on 12 November 2012

Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death

scientific article published on 22 October 2009

Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism

scientific article

CIB1 is a regulator of pathological cardiac hypertrophy

scientific article

Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling

scientific article published on 21 August 2012

Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes

scientific article published on 02 October 2008

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

scientific article published in September 2007

Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis

scientific journal article

CaMKII does it again: even the mitochondria cannot escape its influence

scientific article published in April 2013

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes

scientific article published on 16 July 2009

Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney

scientific article published on February 2011

Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction

scientific article published on 13 November 2003

Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport

scientific article

Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy

article

Calcineurin Increases Cardiac Transient Outward K+Currents via Transcriptional Up-regulation of Kv4.2 Channel Subunits

scientific article published in Journal of Biological Chemistry

Calcineurin Links Mitochondrial Elongation with Energy Metabolism

scientific article

Calcineurin and NFAT4 induce chondrogenesis

scientific article published on 17 September 2002

Calcineurin and beyond: cardiac hypertrophic signaling.

scientific article

Calcineurin and cardiac hypertrophy: where have we been? Where are we going?

scientific article

Calcineurin and human heart failure

scientific article published on 26 July 2002

Calcineurin and hypertrophic heart disease: novel insights and remaining questions

scientific article

Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.

scientific article published on 22 February 2001

Calcineurin protects the heart in a murine model of dilated cardiomyopathy

scientific article

Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: Co-operation with Src tyrosine kinase

scientific article published on 03 June 2006

Calcineurin, Mitochondrial Membrane Potential, and Cardiomyocyte Apoptosis

scientific article published on 01 June 2001

Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

scientific article published in August 2004

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart

scientific article published on August 2006

Calcineurin-induced energy wasting in a transgenic mouse model of heart failure

scientific article

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

scientific article

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

scientific article

Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

scientific article published on 28 October 2009

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy

scientific article published on 25 November 2010

Calcium sparklets regulate local and global calcium in murine arterial smooth muscle

scientific article

Calcium-calcineurin signaling in the regulation of cardiac hypertrophy

scientific article published in October 2004

Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade

scientific article

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

scientific article

Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse

scientific article

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region

scientific article published on 29 January 2007

Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background

scientific article published on 23 February 2009

Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability

article

Cardiac-Specific Loss of N-Cadherin Leads to Alteration in Connexins With Conduction Slowing and Arrhythmogenesis

scientific article published on 11 August 2005

Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations

scientific article

Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart

scientific journal article

Cardiomyocyte Regeneration: A Consensus Statement

scientific article published on 6 July 2017

Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction

scientific article published on 26 February 2014

Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle

scientific article published on 18 October 2004

Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice

scientific article published on 10 March 2016

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart

scientific article published on 11 April 2017

Cdc42 is an antihypertrophic molecular switch in the mouse heart

scientific article published on 08 September 2009

Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo

scientific article

Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors

scientific article

Conditional Transgenic Expression of Fibroblast Growth Factor 9 in the Adult Mouse Heart Reduces Heart Failure Mortality After Myocardial Infarction

scientific article published on 24 January 2011

Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling

scientific article

Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload

scientific article published on 17 August 2012

Contribution of MKP-1 regulation of p38 to endotoxin tolerance.

scientific article

Correction

scholarly article published in Journal of Cell Biology

Corrigendum to “Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active” [Cell Signal 23 (2011) 468–477].

scientific article published in May 2011

Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis

scientific article

Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations

scientific article

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

scientific article

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

scientific article published on 21 September 2008

Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils

scientific article published on 18 February 2016

DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice

scientific article published on February 2004

DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling

scientific article published on 25 May 2016

Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice

scientific article

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice

scientific article published on December 2011

Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy

scholarly article by Matthew J Brody published in April 2018

Defining the regulatory networks for muscle development.

scientific article published on August 1996

Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling

scientific article

Deletion of cytosolic phospholipase A2 promotes striated muscle growth

scientific article

Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-β pathway

scientific article

Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

scientific article

Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point

scientific article published on January 2010

Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling

scientific article

Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart Failure

scientific article published on 01 February 2001

Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease

scientific article published on 17 October 2013

Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart.

scientific article published in January 2000

Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth

scientific article

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth

scientific article

Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling.

scientific article

Divergent Signaling Pathways Converge on GATA4 to Regulate Cardiac Hypertrophic Gene Expression

article

Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?

scientific article published on 24 June 2008

Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules

scientific article

Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

scientific article

Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death

scientific article published on 08 December 2008

Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway.

scientific article

Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.

scientific article

Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity

scientific article

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

scientific article published on 11 June 2015

Erratum: Corrigendum: Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

scholarly article published in Nature Medicine

Erratum: Deletion of cytosolic phospholipase A2 promotes striated muscle growth

scholarly article published in Nature Medicine

Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation

scientific article published on 12 December 2008

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury

scientific article

Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy

scientific article published on 28 July 2014

Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin

scientific article

Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development.

scientific article

Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

scientific article published on February 2010

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes

scientific article

Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth

scientific article

Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis

scientific article published on 29 March 2017

Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis

scientific article published on 11 September 2017

FoxO transcription factors promote autophagy in cardiomyocytes

scientific article published on 19 August 2009

FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress

scientific article

Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.

scientific article published on 17 May 2010

GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling

scientific article

GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.

scientific article

Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling

scientific article published on 13 April 2015

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

scientific article published on 16 March 2008

Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure

scientific article

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

scientific article

Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy

scientific article published on 07 February 2007

Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy

scientific article

Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload

scientific article published on 28 August 2009

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

scholarly article

Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo

scientific article published on 25 July 2005

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

scientific article

Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy

scientific article published on 13 April 2004

Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy

scientific article published on 15 October 2009

Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair

scientific article

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling

scientific article published on 14 June 2007

Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition

scientific article

Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice

scientific article published on 6 January 2016

Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart

scientific article published on 11 March 2004

Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function

scientific article

Helmut Drexler, MD, 1951-2009.

scientific article published in December 2009

High glucose activates nuclear factor of activated T cells in native vascular smooth muscle

scientific article published on 9 February 2006

Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation

scientific article published on 01 November 2019

Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice

scientific article published on 01 April 2000

Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation

scientific journal article

Identifying the components of the elusive mitochondrial permeability transition pore

scientific article

Identity Crisis for Regenerative Cardiac cKit+ Cells

scientific article published in October 2017

Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice

scientific journal article

Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome

scientific article

Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates

scientific article published on 23 December 2017

Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction

scientific article published on 29 July 2010

Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings

scientific article published on 28 December 2015

Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure

scientific article

Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure

scientific article published on 05 October 2007

Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy

scientific article

Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury

scientific article published on 13 October 2011

Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice

scientific article published in April 2002

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

scientific article

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

scientific article published on 28 August 2019

Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion

article

Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes

scientific article published on 5 August 2016

Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling

scientific article published on 8 March 2012

Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point

scientific article published on 11 January 2009

Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death

scientific article

Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?

scientific article published in August 2003

Is p53 the Long-Sought Molecular Trigger for Cyclophilin D–Regulated Mitochondrial Permeability Transition Pore Formation and Necrosis?

scientific article published on 01 October 2012

Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure

scientific article

Knockout of cyclophilin D in Ppif⁻/⁻ mice increases stability of brain mitochondria against Ca²⁺ stress

scientific article

Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease

scientific journal article

Letter by Molkentin regarding article, "The absence of evidence is not evidence of absence: the pitfalls of Cre Knock-Ins in the c-Kit Locus".

scientific article published in September 2014

Locating heart failure

scientific article

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

scientific article (publication date: 31 March 2005)

Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research

scientific article

MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response

scientific article

MEF2B is a potent transactivator expressed in early myogenic lineages

scientific journal article

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo

scientific article published on 19 April 2004

MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration

scientific article

Magnetic resonance imaging assessment of cardiac dysfunction in δ-sarcoglycan null mice

scientific article published on 8 October 2010

Manipulating cardiac contractility in heart failure: data from mice and men.

scientific article

Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.

scientific article published on 12 June 2015

Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle

scientific article

Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome

scientific article published in August 2007

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

scientific article

Mitsugumin 29 regulates t-tubule architecture in the failing heart

scientific article

Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene

scientific article

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

scientific article

Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins ⬇️

scientific journal article

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation ⬇️

scientific article published on December 21, 2010

Molecular analysis of HLA-DR beta and DQ beta polymorphism in Chinese with rheumatoid arthritis

scientific article

Molecular basis of physiological heart growth: fundamental concepts and new players ⬇️

scientific article published on January 1, 2013

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active

scientific article

Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo.

scientific article

Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2

scientific article published in January 1998

Myocyte Enhancer Factors 2A and 2C Induce Dilated Cardiomyopathy in Transgenic Mice

scientific article published in Journal of Biological Chemistry

Myofiber-specific inhibition of TGFβ signaling protects skeletal muscle from injury and dystrophic disease in mice.

scientific article published on 8 August 2014

Myofibroblasts: trust your heart and let fate decide.

scientific article

Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting

scientific article

NFATc3 and NFATc4 Are Required for Cardiac Development and Mitochondrial Function ⬇️

scientific article published on May 15, 2003

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.

scientific article published on 10 June 2015

Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C

scientific article

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart

scientific article

Novel and nondetected human signaling protein polymorphisms

scientific article published on 3 September 2002

Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation

article

Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors

scientific article published in May 2008

Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus.

scientific article

Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

scientific article published on 11 September 2020

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

scientific article

Overexpression of Latent TGFβ Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGFβ

scientific article

Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels

scientific article

Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling

scientific article

Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart

scientific article published in Scientific Reports

P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism

scientific article

PDK1 coordinates survival pathways and beta-adrenergic response in the heart

scientific journal article

PKC-alpha regulates cardiac contractility and propensity toward heart failure

scientific journal article

PKCalpha regulates platelet granule secretion and thrombus formation in mice

scientific article

Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells

scientific article published on June 2013

Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response

scientific article

Periostin as a heterofunctional regulator of cardiac development and disease

scientific article published on December 2008

Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart

scientific article published on 22 February 2008

Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues

scientific article

Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias

scientific article published on 26 November 2015

Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression

scientific article published in August 2017

Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury

scientific article

Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure

scientific article published on 31 July 2006

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway

scientific article

Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.

scientific article

Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity.

scientific article

Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore ⬇️

scientific article published on March 29, 2013

Physiological and pathological roles of the mitochondrial permeability transition pore in the heart

scientific article

Placental growth factor as a protective paracrine effector in the heart

scientific article

Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism

scientific article

Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents

scientific article

Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling

scientific article

Preexisting endothelial cells mediate cardiac neovascularization after injury

scientific article

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

scientific article published on 01 September 1998

Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?

scientific article

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

scientific article

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Protein kinase C alpha enhances sodium–calcium exchange during store-operated calcium entry in mouse platelets ⬇️

scientific article published on November 20, 2010

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

scientific article published on 25 June 2009

Protein kinase Cα as a heart failure therapeutic target

scientific article

RCANs regulate the convergent roles of NFATc1 in bone homeostasis

scientific article published on 05 December 2016

Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function

scientific article published on 05 January 2009

Re-employment of developmental transcription factors in adult heart disease

scientific article published on 24 November 2006

Redefining the identity of cardiac fibroblasts.

scientific article

Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models

scientific article

Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes

scientific article published in March 2002

Regulated necrotic cell death: the passive aggressive side of Bax and Bak

scientific article

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells

scientific article published on 29 May 2011

Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo

scientific article

Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs).

scientific article

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

scientific article published on 26 June 2007

Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes

scientific article

Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy

scientific article

Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila

scientific article

Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis

scientific journal article

Requirement of transcription factor NFAT in developing atrial myocardium

scientific journal article

Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.

scientific article

Response to Torella et al

article

Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.

scientific article

RhoA protects the mouse heart against ischemia/reperfusion injury

scientific article published on 11 July 2011

RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.

scientific article

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome

scholarly article

SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models

scientific article published on 4 February 2015

STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy

scientific article

STRESS signaling pathways that modulate cardiac myocyte apoptosis

scientific article

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

scientific article

Sarcolipin overexpression improves muscle energetics and reduces fatigue

scientific article

Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo

scientific article

Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells.

scientific article

Signaling effectors underlying pathologic growth and remodeling of the heart ⬇️

scientific article published on January 2, 2013

Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX.

scientific article published in October 2017

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

scientific article published on 16 April 2018

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

scientific article published on 5 August 2014

T-type Ca²⁺ channels regulate the exit of cardiac myocytes from the cell cycle after birth.

scientific article published on 04 June 2013

TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways

scientific article

TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction

scientific article

TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2

scientific article published on 15 August 2008

TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury

scientific article published on 27 July 2017

TOX provides a link between calcineurin activation and CD8 lineage commitment

scientific article

TRPC channels are necessary mediators of pathologic cardiac hypertrophy

scientific article

TRPC channels as effectors of cardiac hypertrophy

scientific article published on January 2011

Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts

scientific article published on 6 November 2009

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth

scientific article

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

scientific article

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

scientific article

Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo

scientific article

Targeting latent TGFβ release in muscular dystrophy

scientific article published on October 2014

Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart

scientific article published on 31 October 2005

The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment

scientific article

The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension

scientific article published on 12 September 2019

The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away

scientific article published on January 2017

The IP3 receptor regulates cardiac hypertrophy in response to select stimuli

scientific article

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

scientific article published on 25 June 2015

The Transcription Factor C/EBPβ Serves as a Master Regulator of Physiologic Cardiac Hypertrophy

scientific article published on 01 February 2011

The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy

scientific article (publication date: June 2006)

The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

scholarly article

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

scientific article

The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice

scientific article published on 09 March 2009

The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation.

scientific article

The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling

scientific article published on 13 February 2006

The protein phosphatase calcineurin determines basal parathyroid hormone gene expression

scientific article

The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses

scientific article

The transcription factor GATA-6 regulates pathological cardiac hypertrophy

scientific journal article

The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes

scientific article

The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.

scientific article

The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism

scientific journal article

The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury

scientific article published on 5 January 2006

The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

scientific article

The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling.

scientific article

Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure

scientific article published on 24 January 2013

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

scientific article

Thrombospondin expression in myofibers stabilizes muscle membranes.

scientific article published on 26 September 2016

Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability

scientific article published in Nature Communications

Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA

scientific article

Transforming growth factor β-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling

scientific article

Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction

scientific article

Tropomyosin dephosphorylation results in compensated cardiac hypertrophy

scientific article

Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte

scientific article published on 11 May 2011

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis

scholarly article

Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.

scientific article published on 19 September 2012

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

scientific article

With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure

scientific article published on 19 September 2008

alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice

scientific article published on 16 November 2009

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

scientific article published on October 2003

c-kit+ cells minimally contribute cardiomyocytes to the heart

scientific article

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