List of works by Daniel F Legler

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

scientific article

A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins

scientific article published on 21 November 2017

A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking.

scientific article published on 30 March 2018

Activation-dependent modulation of B lymphocyte migration to chemokines

scientific article published on 01 September 2000

Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator

scientific article published on 27 February 2015

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

scientific article published on 22 July 2020

B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5

scientific article

Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions

scientific article published on 18 April 2018

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

scientific article published on 13 September 2019

CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation

scientific article

CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells

scientific article published on 16 May 2018

CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2 ⬇️

scientific article published on October 30, 2003

CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4

scientific article published on 01 June 2020

CCR5 deficiency/CCR5Δ32: resistant to HIV infection at the cost of curtailed CD4+ T cell memory responses

scientific article published on 08 July 2020

CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

scientific article published on 01 January 2018

CCR7: roles in cancer cell dissemination, migration and metastasis formation.

scientific article

CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity

scientific article published on 02 July 2020

CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems

scientific article published on 05 October 2020

Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes

scientific article published on 01 February 2001

Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation

scientific article published on 01 October 2019

Chemokine axes in breast cancer: factors of the tumor microenvironment reshape the CCR7-driven metastatic spread of luminal-A breast tumors

scientific article published on 2 March 2016

Chemokines: Chemistry, Biochemistry and Biological Function.

scientific article

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes.

scientific article published on 4 January 2016

Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E₂ and liver X receptor activation

scientific article published on 26 September 2012

Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration

scientific article published on 31 October 2011

Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.

scientific article published on 23 August 2010

Differential insertion of GPI-anchored GFPs into lipid rafts of live cells.

scientific article

Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses.

scientific article published on 27 January 2016

Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E(2)

scientific article published on 01 March 2012

Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis

scientific article published on 29 July 2008

Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7.

scientific article

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.

scientific article

Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1.

scientific article

FAT10 localizes in dendritic cell aggresome-like induced structures and contributes to their disassembly

scientific article published on 16 June 2020

Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions

scientific article published on 04 December 2018

IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation

scientific article published on 12 February 2019

Identification of CCR8, the receptor for the human CC chemokine I-309

scientific article (publication date: 11 July 1997)

Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells

scientific article published on 13 May 2010

In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell-Mediated Host Surveillance

scientific article published on 23 September 2019

In vivo TCR Signaling in CD4(+) T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity

scientific article published on 8 June 2015

Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition

scientific article

Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration

scientific article published in January 2016

Interstitial dendritic cell guidance by haptotactic chemokine gradients

scientific article

Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity.

scientific article

Loss of Gadkin Affects Dendritic Cell Migration In Vitro

scientific article published in December 2015

Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics

scientific article published in 2022

Membrane Compartmentalization and Scaffold Proteins in Leukocyte Migration

scientific article published on 28 April 2020

Membrane lipid environment: Potential modulation of chemokine receptor function.

scientific article published on 9 February 2018

Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention.

scientific article

New insights in chemokine signaling.

scientific article published on 23 January 2018

On the move: endocytic trafficking in cell migration.

scientific article

Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation.

scientific article published on August 2006

Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts

scientific article published on 6 December 2005

Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells

scientific article published on 01 February 2006

Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon

scientific article published on 23 June 2008

Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.

scientific article published on 27 September 2009

Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO

scholarly article by Petra Krause et al published 14 August 2007 in Journal of Leukocyte Biology

Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors

scientific article

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

scientific article published in May 2003

Regulation of Sec16 levels and dynamics links proliferation and secretion

scientific article published on 19 December 2014

Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake

scientific article published on 25 April 2022

Soluble major histocompatibility complex-peptide octamers with impaired CD8 binding selectively induce Fas-dependent apoptosis

scientific article published on 28 October 2002

TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function.

scientific article

The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation

scientific article published on 10 April 2003

The dimeric form of CXCL12 binds to atypical chemokine receptor 1

scientific article published on 17 August 2021

V domain of RAGE interacts with AGEs on prostate carcinoma cells.

scientific article

ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins

scientific article published on 28 March 2018

β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4

scientific article published on 18 September 2020

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