List of works - Valentina Bonetto

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10

scientific article

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

scientific article published on February 2013

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

scientific article

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets

scientific article published on 27 November 2013

Actin glutathionylation increases in fibroblasts of patients with Friedreich's ataxia: a potential role in the pathogenesis of the disease

scientific article published on 11 August 2003

Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells

scientific article (publication date: 2011)

Characterization of antimalarial SPf66 peptide using MALDI-TOF MS, CD and SEC.

scientific article

Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.

scientific article

Combination of fast chromatographic separations, biosensor-based functional assays, and mass spectrometry for characterization of complex peptide mixtures.

scientific article

Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice

scientific article published on 22 December 2021

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

scientific article published on 10 August 2021

Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis.

scientific article published on 06 April 2017

Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis.

scientific article published on 2 July 2014

Extracellular Vesicles and a Novel Form of Communication in the Brain

scientific article

Extracellular acidification: a novel detection system for ligand/receptor interactions. Demonstration with bioactive peptides and CHO or pancreatic beta cells, but of possible interest for tracing putative receptors in ethanol metabolism

scientific article published on 01 January 1999

Focus on the heterogeneity of amyotrophic lateral sclerosis

scientific article published on 25 June 2020

Full-length and N-terminally truncated chicken intestinal diazepam-binding inhibitor

scientific article published on 01 March 1997

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems

scientific article

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

scientific article

Insoluble Mutant SOD1 Is Partly Oligoubiquitinated in Amyotrophic Lateral Sclerosis Mice

scientific article published in Journal of Biological Chemistry

Introduction

scientific article published on 01 March 2016

Isolation of peptides from porcine intestinal tissue that induce extracellular acidification in CHO cells: identification of the active peptide as IGF-I and characterization of a fragment of calponin H1 processed at a dibasic site.

scientific article

Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression

scientific article published on 04 June 2015

Large-scale HPLC purification of calbindin D9k from porcine intestine

scientific article published on 01 December 1999

Micro-computed tomography for non-invasive evaluation of muscle atrophy in mouse models of disease.

scientific article

Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis

scientific article published on 16 April 2013

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway

scientific article

Myosin as a potential redox-sensor: an in vitro study.

scientific article

New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models.

scientific article

Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS.

scientific article published in July 2009

Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes

scientific article

Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse.

scientific article

Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1

scientific journal article

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue.

scientific article

Redox proteomics: identification of oxidatively modified proteins.

scientific article

Redox regulation of cyclophilin A by glutathionylation.

scientific article published in February 2006

Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics

scientific article

Regulation of redox-sensitive exofacial protein thiols in CHO cells.

scientific article published on October 2006

Serological Proteome Analysis (SERPA) as a tool for the identification of new candidate autoantigens in type 1 diabetes

scientific article published on 14 March 2013

Synthetic miniprion PrP106.

scientific article

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.

scientific article published on 23 December 2016

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins

scientific article (publication date: 2011)

The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells

scientific article

Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation.

scientific article

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.

scientific article

List of works by Valentina Bonetto

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10

A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity

A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets

Actin glutathionylation increases in fibroblasts of patients with Friedreich's ataxia: a potential role in the pathogenesis of the disease

Amyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cells

Characterization of antimalarial SPf66 peptide using MALDI-TOF MS, CD and SEC.

Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.

Combination of fast chromatographic separations, biosensor-based functional assays, and mass spectrometry for characterization of complex peptide mixtures.

Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis.

Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis.

Extracellular Vesicles and a Novel Form of Communication in the Brain

Extracellular acidification: a novel detection system for ligand/receptor interactions. Demonstration with bioactive peptides and CHO or pancreatic beta cells, but of possible interest for tracing putative receptors in ethanol metabolism

Focus on the heterogeneity of amyotrophic lateral sclerosis

Full-length and N-terminally truncated chicken intestinal diazepam-binding inhibitor

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems

IL-7-induced phosphorylation of the adaptor Crk-like and other targets.

Insoluble Mutant SOD1 Is Partly Oligoubiquitinated in Amyotrophic Lateral Sclerosis Mice

Introduction

Isolation of peptides from porcine intestinal tissue that induce extracellular acidification in CHO cells: identification of the active peptide as IGF-I and characterization of a fragment of calponin H1 processed at a dibasic site.

Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression

Large-scale HPLC purification of calbindin D9k from porcine intestine

Micro-computed tomography for non-invasive evaluation of muscle atrophy in mouse models of disease.

Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway

Myosin as a potential redox-sensor: an in vitro study.

New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models.

Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS.

Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes

Proteomic analysis of spinal cord of presymptomatic amyotrophic lateral sclerosis G93A SOD1 mouse.

Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue.

Redox proteomics: identification of oxidatively modified proteins.

Redox regulation of cyclophilin A by glutathionylation.

Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics

Regulation of redox-sensitive exofacial protein thiols in CHO cells.

Serological Proteome Analysis (SERPA) as a tool for the identification of new candidate autoantigens in type 1 diabetes

Synthetic miniprion PrP106.

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins

The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells

Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation.

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.